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Frans Mulder

Lektor

Curriculum Vitae


Personal details

 

Name
Date of birth
Place of Birth
Nationality
Marital status
Office address

Frans Mulder
2 April 1969
Hoogland, The Netherlands 
Dutch
Married
Associate Professor of Biological NMR
Interdisciplinary Nanoscience Center (iNANO) and
Department of Chemistry, University of Aarhus
Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

Office      1593-221
Phone    +45 871 55889
Cell       +45 51447344
Email  fmulder@chem.au.dk
www.protein-nmr.org, inano.au.dk
nmr.au.dk

 

 


Language Skills

 

speak

understand

write

English

excellent

excellent

excellent

Dutch (native)

excellent

excellent

excellent

German

good

excellent

fair

French

fair

good

fair

Italian

good

good

good

Swedish

very good

excellent

very good

Danish

very good

excellent

very good

 

Research Interests

Structural biology, NMR spectroscopy, dynamics and thermodynamics of biomolecules, protein biophysics, protein electrostatics, protein engineering, intrinsically disordered proteins, protein aggregation and disease, bioinformatics, metabolomics, in cell and in vivo spectroscopy

 

 

Academic background

 2011- now

Associate Professor of Biological NMR
Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry,
University of Aarhus, Denmark

2016-2017

Visiting scientist (sabbatical)
Centro di Ricerca di Risonanze Magnetiche (CERM)
Università degli Studi Firenze, Firenze, Italy (Prof.dr. C. Luchinat / Prof.dr. L. Banci)

2015-2016

Visiting Professor
Università degli Studi di Roma Tor Vergata
Roma, Italy (Dr. M. Sette)

2005-2011

Principal Investigator and NMR spectroscopy group leader

Dept of Molecular Dynamics, Groningen Biomolecular sciences and Biotechnology Institute, University of Groningen, the Netherlands
2006 recipient of a "VIDI" grant (€ 600,000) from the Netherlands Organization for Scientific Research (NWO). Title: "Natively unfolded proteins, aggregation and disease"

2007 recipient of a "Van Gogh" stipend (€ 20,000) to foster scientific cooperation and exchange between researchers from The Netherlands and France

2005

Visiting scientist

Department of Biological Sciences, Biochemistry division, University of Calgary, Canada (Prof.dr. H. J. Vogel)

2001-2004

Post-doctoral fellow
Department of Biophysical Chemistry, Lund University, Sweden
(Prof.dr. B. Halle & Prof.dr. M. Akke). 
Department of Molecular Biophysics, Lund University, Sweden

(Anders Liljas; 15/04/2004-30/11/2004)
Recipient of a stipendium awarded by the Federation of European Biochemical Societies (FEBS; 01/09/2001 - 14/04/2002 ; awarded until 31/08/2003)
Recipient of a Marie Curie Fellowship awarded by the European Union (EU)
(contract HPMF-CT-2001-02145; 15/04/2002-14/04/2004)

1999-2001

Post-doctoral fellow
Department of Medical Genetics, University of Toronto, Canada
(Prof.dr. L.E. Kay). 
Recipient of a "TALENT" stipendium awarded by the Netherlands Organization for Scientific Research (NWO; 01/02/1999-31/01/2000)
Recipient of a Long Term Fellowship awarded by the European Molecular Biology Organization (EMBO; ALTF 382-1999; 01/02/2000 - 31/01/2001)

1998

Ph.D. in Chemistry (16 Dec 1998)
Department of NMR spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
(promotores: Prof.dr. R. Boelens, Prof.dr. R. Kaptein) 
Thesis: NMR relaxation studies of protein dynamics in solution

Awarded "cum laude" (top 5%) Externals: Arthur G Palmer III & Lewis E Kay

1994

Visiting scientist
Department of Physical Chemistry, Arrhenius Laboratory, Stockholm University, Sweden (Prof.dr. J. Kowalewski, Dr. L. Mäler).  
Recipient of a "Svenska Institutet" scholarship

1993

M.Sc. in Chemistry (29 Nov 1993), 
Utrecht University, The Netherlands.
Major specialization: NMR spectroscopy
(Dr. K. Hård, Prof.dr. R. Kaptein).

1992

Exchange student at the Department of Agrarian Chemistry, University of Bologna, Italy (Prof.dr. C. Luchinat, Dr. F. Capozzi).
Recipient of a "Collegio dei Fiamminghi" scholarship

 

 

List of Original Research Papers

  1. Lena Mäler, Frans A.A. Mulder & Jozef Kowalewski "Paramagnetic cross-correlation effects in the longitudinal proton relaxation of cis- chloroacrylic acid in the presence of Nickel(II) ions" J. Magn. Reson. A, 117 (1995), 220-227  
  2. Frans A.A. Mulder, Chris A.E.M. Spronk, Monique Slijper, Robert Kaptein & Rolf Boelens "Improved HSQC experiments for the observation of exchange broadened signals" J. Biomol. NMR, 8 (1996), 223-228  
  3. John R. Martin, Frans A.A. Mulder, Yasmin Karimi-Nejad, Johan van der Zwan, Matteo Mariani, Dick Schipper & Rolf Boelens "The solution structure of serine protease PB92 from B. alcalophilis presents a rigid fold with a flexible substrate binding site" Structure, 5 (1997), 521-532  
  4. Marco Tessari, Frans A.A. Mulder, Rolf Boelens & Geerten Vuister "Determination of amide proton CSA in 15N labeled proteins using 1H CSA/15N-1H dipolar and 15N CSA/15N-1H dipolar cross-correlation rates" J. Magn. Reson., 127 (1997), 128-133  
  5. Frans A.A. Mulder, Robin A. de Graaf, Rob Kaptein & Rolf Boelens "An off-resonance rotating frame relaxation experiment for the investigation of macromolecular dynamics using adiabatic rotations" J. Magn. Reson., 131 (1998), 351-357  
  6. Gilles Rubinstenn, Geerten W. Vuister, Frans A.A. Mulder, Petra E. Düx, Rolf Boelens, Klaas Hellingwerf & Robert Kaptein "Structural and dynamic changes of photoactive yellow protein during its photocycle in solution" Nature Struct. Biology, 5 (1998), 568-570 
  7. Petra E. Düx, Gilles Rubinstenn, Geerten W. Vuister, Rolf Boelens, Frans A.A. Mulder, Kalle Hård, Wouter D. Hoff, Arthur Kroon, Wim Crielaard, Klaas J. Hellingwerf & Robert Kaptein "Solution structure and dynamics of the Photoactive Yellow Protein" Biochemistry, 37 (1998), 12689-12699 
  8. Paul J.A. van Tilborg, Frans A.A. Mulder, Maaike M.E. de Backer, Margie Nair, Erika C. van Heerde, Gert Folkers, Paul T. van der Saag, Yasmin Karimi-Nejad, Rolf Boelens & Rob Kaptein "Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation" Biochemistry, 38 (1999), 1951-1956 
  9. Frans A.A. Mulder, Paul J.A. van Tilborg, Rob Kaptein and Rolf Boelens "Microsecond time scale dynamics in the RXR DNA-binding domain from a combination of spin-echo and off-resonance rotating frame relaxation measurements" J. Biomol. NMR, 13 (1999), 275-288 
  10. Yasmin Karimi-Nejad, Frans A.A. Mulder, John R. Martin, Axel T. Brünger, Dick Schipper & Rolf Boelens "NMR Studies of the 269 residue serine protease PB92 from B. alcalophilis" in: NMR in Supramolecular Chemistry (M. Pons Ed.), (1999), 227-246 Kluwer Academic Publishers, Dordrecht, the Netherlands
  11. Frans A.A. Mulder, Dick Schipper, Richard Bott & Rolf Boelens "Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins" J. Mol. Biol., 292 (1999), 111-123
  12. Paul J.A. van Tilborg, Michael Czisch, Frans A.A. Mulder, Gert E. Folkers, Alexandre M.J.J Bonvin, Margie Nair, Rolf Boelens & Rob Kaptein "Changes in dynamical behaviour of the retinoid X receptor DNA-binding domain upon binding to a 14 base pair DNA half site", Biochemistry (Accelerated), 39 (2000), 8747-8757
  13. Frans A.A. Mulder, Ayeda Ayed, Daiwen Yang, Cheryl H. Arrowsmith & Lewis E. Kay "Assignment of 1HN, 15N, 13Ca, 13CO and 13Cb  resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy", J. Biomol. NMR, 18 (2000), 173-176
  14. Frans A.A. Mulder, Bin Hon, D. Ranjith Muhandiram, Frederick W. Dahlquist & Lewis E. Kay "Flexibility and ligand exchange in a buried cavity mutant of T4 lysozyme studied by multi-nuclear NMR", Biochemistry, 39 (2000), 12614-12622
  15. Frans A.A. Mulder, Nikolai R. Skrynnikov, Bin Hon, Frederick W. Dahlquist & Lewis E. Kay "Measurement of slow (ms-ms) timescale dynamics in proteins sidechains by 15N relaxation dispersion NMR spectroscopy: Application to Asn and Gln residues in a cavity mutant of T4 lysozyme", J. Am. Chem. Soc., 123 (2001), 967-975
  16. Nikolai R. Skrynnikov, Frans A.A. Mulder, Bin Hon, Frederick W. Dahlquist & Lewis E. Kay "Probing slow timescale dynamics at methyl-containing sidechains in proteins by relaxation dispersion NMR measurements: Application to methionine residues in a cavity mutant of T4 lysozyme", J. Am. Chem. Soc., 123 (2001), 4556-4566
  17. Ayeda Ayed, Frans A.A. Mulder, Gwan-Su Yi, Ying Lu, Lewis E. Kay & Cheryl H. Arrowsmith "Latent and active p53 are identical in conformation" Nature Struct Biology, 8 (2001), 756-760
  18. Martin Tollinger, Nikolai R. Skrynnikov, Frans A.A. Mulder, Julie Forman-Kay & Lewis E. Kay "Slow dynamics in folded and unfolded states of an SH3 domain" J. Am. Chem. Soc., 123 (2001), 11341-11352
  19. Frans A.A. Mulder, Anthony Mittermaier, Bin Hon, Frederick W. Dahlquist & Lewis E. Kay "Studying excited states of proteins by relaxation dispersion NMR spectroscopy", Nature Struct Biology, 8 (2001), 932-935
  20. Wing-Yiu Choy, Frans A. A. Mulder, Karin A. Crowhurst, D. R. Muhandiram, Ian S. Millett, Sebastian Doniach, Julie D. Forman-Kay & Lewis E. Kay "Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques" J Mol Biol 316 (2002),101-112
  21. Frans A.A. Mulder, Bin Hon, Anthony Mittermaier, Frederick W. Dahlquist & Lewis E. Kay "Slow internal dynamics in proteins: Application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme", J. Am. Chem. Soc., 124 (2002), 1443-1451
  22. Frans A.A. Mulder & Mikael Akke "Carbonyl 13C transverse relaxation measurements to sample protein backbone dynamics", Magn. Reson. Chem., 41 (2003), 853-865
  23. Frans A.A. Mulder, Lamine Bouakaz, Anna Lundell, Anders Liljas, Mikael Akke & Suparna Chandra Sanyal “Conformation and dynamics of protein L12 in solution and on the ribosomal stalk”, Biochemistry (Accelerated), 43 (2004), 5930-5936
  24. Patrik Lundström, Frans A.A. Mulder & Mikael Akke "Correlated dynamics of consecutive residues reveal transient and cooperative unfolding of secondary structure in proteins", Proc. Natl. Acad. Sci. USA, 102 (2005) 16984-16989
  25. Ulrika Brath, Mikael Akke, Daiwen Yang, Lewis E. Kay & Frans A.A. Mulder "Functional dynamics of human FKBP12 revealed by methyl 13C rotating frame relaxation dispersion NMR spectroscopy", J. Am. Chem. Soc., 128 (2006), 5718-5727
  26. Stina Lindman, Sara Linse, Frans A.A. Mulder & Ingemar André "Electrostatic contributions to residue-specific protonation equilibria and proton binding capacitance for a small protein", Biochemistry, 45 (2006), 13993-14002
  27. Stina Lindman, Sara Linse, Frans A.A. Mulder & Ingemar André "pK(a) values for side-chain carboxyl groups of a PGB1 variant explain salt and pH-dependent stability", Biophys. J., 92 (2007), 257-266
  28. Magnus Helgstrand, Chandra S. Mandava, Frans A.A. Mulder, Anders Liljas, Suparna C. Sanyal & Mikael Akke " The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain", J. Mol. Biol., 365 (2007), 468-479
  29. Ingemar André, Sara Linse & Frans A.A. Mulder "Residue-specific pKa determination of lysine and arginine side chains by indirect 15N and 13C NMR spectroscopy: Application to apo calmodulin", J. Am. Chem. Soc., 129 (2007), 15805-15813
  30. Aviv Paz, Tzviya Zeev-Ben-Mordehai,Eilon Sherman, Efstratios Mylonas, Lev Weiner, Gilad Haran, Dmitri I. Svergun, Frans A. A. Mulder, Joel L. Sussman& Israel Silman "Biophysical Characterization of the Unstructured Cytoplasmic Domain of the Human Adhesion Protein Neuroligin 3", Biophys. J., 95 (2008), 1928-1944
  31. Raphael Paquin, Fabien Ferrage, Frans A.A. Mulder*, Mikael Akke & Geoffrey Bodenhausen "Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by 13C Nuclear Spin Relaxation", J. Am. Chem. Soc., 130 (2008), 15805-15807 (corresponding author)
  32. Frans A.A. Mulder "Leucine Side Chain Conformation and Dynamics in Proteins from 13C Chemical Shifts", ChemBioChem, 10 (2009), 1477-1479
  33. Renee Otten, Kathleen Wood & Frans A.A. Mulder "Comprehensive determination of 3JHNHa for unfolded proteins using 13C'-resolved spin-echo difference spectroscopy", J. Biomol. NMR, 45 (2009), 343-348
  34. D. Flemming Hansen, Philipp Neudecker, Pramodh Vallurupalli, Frans A. A. Mulder & Lewis E. Kay "Determination of Leu side-chain conformations in excited protein states by NMR", J. Am. Chem. Soc., 132 (2010) 42-43 DOI: 10.1021/ja909294n
  35. Frans A.A. Mulder & Michael Filatov "NMR chemical shift data and ab initio shielding calculations: Emerging tools for protein structure determination" Chem. Soc. Rev., 39 (2010) 578–590
  36. Renee Otten, Byron Chu, Karla D. Krewulak, Hans J. Vogel & Frans A.A. Mulder "Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins", J. Am. Chem. Soc, 132 (2010) 2952-60
  37. Kathleen Wood, Douglas J. Tobias, Brigitte Kessler, Frank Gabel, Dieter Oesterhelt, Frans A.A. Mulder, Giuseppe Zaccai & Martin Weik "The low temperature inflection observed in the neutron scattering of proteins is due to methyl rotation: direct evidence using isotope labelling and molecular dynamics simulations", J. Am. Chem. Soc. 132 (2010) 4990-4991
  38. Renee Otten, Janice Villali, Dorothee Kern & Frans A.A. Mulder "Probing microsecond time scale dynamics in proteins by methyl 1H CPMG relaxation dispersion NMR measurements. Application to activation of the signaling protein NtrCr", J. Am. Chem. Soc., 132 (2010) 17004-17014; DOI: 10.1021/ja107410x
  39. Stina Lindman, Mikael C. Bauer, Mikael Lund, Carl Diehl, Frans A.A. Mulder, Mikael Akke & Sara Linse "pKa values for the unfolded state under native conditions explain the pH dependent stability of PGB1", Biophys. J. 99 (2010) 3365-3373
  40. Kamil Tamiola, Burçin Acar & Frans A.A. Mulder "Sequence-specific random coil chemical shifts of intrinsically disordered proteins", J. Am. Chem. Soc., 132 (2010) 18000-18003
  41. Nur Alia Oktaviani, Renee Otten, Klaas Dijkstra, Ruud M. Scheek, Eva Thulin, Mikael Akke & Frans A.A. Mulder  "100% complete assignment of non-labile 1H, 13C, and 15N signals for calcium-loaded Calbindin D9k P43G", Biomol. NMR Assign. 5 (2011) 79-84
  42. Kamil Tamiola & Frans A.A. Mulder "ncIDP-assign: a SPARKY extension for the rapid assignment of intrinsically disordered proteins", Bioinformatics 27 (2011) 1039-1040
  43. Anne C. Meinema, Justyna K. Łaba, Rizqiya A. Hapsari, Renee Otten, Frans A. A. Mulder, Annemarie Kralt, Geert van den Bogaart, C. Patrick Lusk, Bert Poolman & Liesbeth M. Veenhoff "Long unfolded linkers facilitate membrane protein import through the nuclear pore complex" Science 333(6038) (2011) 90-93
  44. Kevin H. Gardner, Anthony Mittermaier & Frans A.A. Mulder "A tribute to Lewis E Kay on his 50th birthday" J. Biomol. NMR. 51 (2011) 3-4.
  45. Frans A.A. Mulder, Renee Otten & Ruud M. Scheek "Origin and removal of mixed-phase artifacts in Gradient Sensitivity Enhanced correlation spectra" J. Biomol. NMR, 51 (2011) 199-207.
  46. Akira Karasawa, Guus B. Erkelens, Ronnie P-A Berntsson, Renee Otten, Gea K. Schuurman-Wolters, Frans A.A. Mulder & Bert Poolman "CBS domains 1 and 2 fulfill different roles in the ionic strength-sensing of the ABC transporter OpuA" J Biol. Chem. 286 (2011) 37280-91
  47. Nur Alia Oktaviani, Trijntje J. Pool, Jelle Slager, Ruud M. Scheek, Hironari Kamikubo, Mikio Kataoka & Frans A.A. Mulder "Comprehensive determination of individual protein tyrosine pKa constants by indirect 13C NMR spectroscopy: Application to Photoactive Yellow Protein" Biophys J, 102 (2012) 579-586
  48. Kathleen Wood, Aviv Paz, Renee Otten, Klaas Dijkstra, Ruud M. Scheek, Israel Silman, Joel Sussman & Frans A.A. Mulder "Backbone and side chain assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3" Biomol. NMR Assign. 6 (2012) 15-18
  49. Kamil Tamiola & Frans A.A. Mulder "Using NMR chemical shifts to calculate the propensity for structural order and disorder in proteins" Biochemical Society Transactions, 40(5) (2012) 1014-1020
  50. Trijntje J. Pool, Nur Alia Oktaviani, Hironari Kamikubo, Mikio Kataoka & Frans A.A. Mulder "1H, 13C, and 15N resonance assignment of photoactive yellow protein" Biomol. NMR Assign. 7 (2013) 97-100
  51. Kathleen Wood, François-Xavier Gallat, Renee Otten, Auke van Heel, Mathilde Lethier, Lambert van Eijck, Martine Moulin, Michael Haertlein, Martin Weik & Frans A.A. Mulder "Protein surface and core dynamics show concerted hydration- dependent activation" Angewandte Chemie (Int. Ed. Engl.) 52(2) (2013) 665–668
  52. Christina Avanti, Nur Alia Oktaviani, Wouter L.J. Hinrichs, Henderik W. Frijlink & Frans A.A. Mulder "Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation" Int. J. Pharm. 444(1-2) (2013) 139-45
  53. Renée Roodbeen, Berit Paaske, Longguang Jiang, Jan K. Jensen, Anni Christensen, Jakob T. Nielsen, Mingdong Huang, Frans A. A. Mulder, Niels C. Nielsen, Peter A. Andreasen & Knud J. Jensen "Bicyclic peptide inhibitor of urokinase-type plasminogen activator: mode of action" ChemBioChem 14(16) (2013), 2179-2188
  54. Tiernan T. O’Malley, Nur Alia Oktaviani, Dainan Zhang, Aleksey Lomakin, Brian O’Nuallain, Sara Linse, George B. Benedek, Michael J. Rowan, Frans A. A. Mulder & Dominic M. Walsh, "Aβ dimers have aggregation paths distinct from monomer and persistently populate toxic intermediates" Biochemical J 461(3) (2014), 413-426
  55. Nikolai Lorenzen, Søren B. Nielsen, Yuichi Yoshimura, Camilla Bertel Andersen, Cristine Betzer, Brian S. Vad, Jørn D. Kaspersen, Gunna Christiansen, Jan S. Pedersen, Poul Henning Jensen, Frans A. A. Mulder & Daniel E. Otzen"How epigallogatechin gallate can inhibit α-synuclein oligomer toxicity in vitro" J Biol Chem 289(31) (2014), 21299-21310 (awarded J Biol Chem paper of the week)
  56. Byron Chu, Renee Otten, Karla D. Krewulak, Frans A.A. Mulder & Hans J. Vogel "The structure, binding properties and dynamics of the 34 kDa bacterial siderophore binding protein FepB in solution" J Biol. Chem. 289(42) (2014), 29219-34
  57. Akihiro Maeno, Daniel Sindhikara, Fumio Hirata, Renee Otten, Frederick W. Dahlquist, Shigeyuki Yokoyama, Kazuyuki Akasaka, Frans A. A. Mulder & Ryo Kitahara "Cavity as a Source of Conformational Fluctuation and High-Energy State: High-Pressure NMR Study of a Cavity-Enlarged Mutant of T4 Lysozyme" Biophys J. 108(1) (2015), 133-45
  58. Zebin Hong, Michal Nowakowski, Chris Spronk, Steen V. Petersen, Jan Skov Pedersen, Peter A. Andreasen, Wiktor Koźmiński, Frans A. A. Mulder & Jan K. Jensen "The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Inhibitor 1 reveals an unexpected PAN/apple domain-type fold" Biochemical J. 466(2) (2015) 299-309
  59. Yuichi Yoshimura, Natalia V. Kulminskaya & Frans A.A. Mulder “Easy and unambiguous sequential assignments of intrinsically disordered proteins by correlating the backbone 15N or 13C’ chemical shifts of multiple contiguous residues in highly resolved 3D spectra” J Biomol NMR 61 (2015) 109–121
  60. Mathias A.S. Hass & Frans A.A. Mulder "Contemporary NMR studies of protein electrostatics" Annu. Rev. Biophys. 44 (2015) 53-75
  61. Ryo Kitahara & Frans A.A. Mulder “Is pressure-induced signal loss in NMR spectra for the Leu99Ala cavity mutant of T4 lysozyme due to unfolding?” Proc Natl Acad Sci USA 112(9) (2015) E923
  62. Nur Alia Oktaviani, Michael Wulff Risør, Young-Ho Lee, Rik P. Megens, Djurre H. de Jong, Renee Otten, Ruud M. Scheek, Jan J. Enghild, Niels Chr. Nielsen, Takahisa Ikegami & Frans A.A. Mulder "Optimized Co-Solute Paramagnetic Relaxation Enhancement for the Rapid NMR Analysis of a Highly Fibrillogenic Peptide" J Biomol NMR 62 (2015) 129–142
  63. Heidi Gytz Olesen, Durita Mohr, Paulina Seweryn, Yuichi Yoshimura, Zarina Kutlubaeva, Fleur Dolman, Bosene Chelchessa, Alexander B. Chetverin, Frans A.A. Mulder, Ditlev E. Brodersen & Charlotte R. Knudsen "Structural basis for RNA-genome recognition during bacteriophage Qb replication"Nucleic Acids Res. 43(22) (2015) 10893–10906
  64. Natalia V. Kulminskaya, Yuichi Yoshimura, Kasper Runager, Charlotte S. Sørensen, Morten Bjerring, Maria Andreasen, Daniel Otzen, Jan J. Enghild, Niels Chr. Nielsen & Frans A. A. Mulder "Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T" Biomol. NMR Assign. 10(1) (2016) 25-29
  65. Ryo Kitahara, Yuichi Yoshimura, Mengjun Xue, Tomoshi Kameda & Frans A.A. Mulder "Detecting O2 binding sites in protein cavities" Sci. Rep. 6:20534(2016) 1-12
  66. Jakob Toudahl Nielsen & Frans A.A. Mulder "There is Diversity in Disorder - In all chaos there is a cosmos, in all disorder a secret order" Front. Mol. Biosci. 3:4 (2016) 1-12
  67. Mengjun Xue, Ryo Kitahara, Yuichi Yoshimura & Frans A.A. Mulder "Aberrant Increase of NMR Signal in Hydrogen Exchange Experiments: Observation and Explanation" Biochem. Biophys. Res. Commun. 478(3) (2016) 1185-1188
  68. Yuichi Yoshimura, Nur Alia Oktaviani, Kento Yonezawa, Hironari Kamikubo & Frans A. A. Mulder "Determination of Protein Arginine Ionization States in Solution by NMR Spectroscopy" Angew. Chem. Int. Ed. Engl., 56(1) (2017) 239-242
  69. Yuichi Yoshimura, Mats A. Holmberg, Predrag Kukic, Camilla B. Andersen, Alejandro Mata-Cabana, Michele Vendruscolo, Ellen A.A. Nollen & Frans A.A. Mulder "MOAG-4 Promotes the Aggregation of α-Synuclein by Competing with Self-protective Electrostatic Interactions" J. Biol Chem 292(20) (2017) 8269-8278
  70. Nur Alia Oktaviani, Trijntje J. Pool, Yuichi Yoshimura, Hironari Kamikubo, Ruud M. Scheek, Mikio Kataoka & Frans A.A. Mulder "Active-Site pKa Determination for Photoactive Yellow Protein Rationalizes Slow Ground-State Recovery", Biophys J. 112(10) (2017) 2109–2116
  71. Ryo Kitahara, Shun Sakuraba, Tomoshi Kameda, Sanshiro Okuda, Mengjun Xue & Frans A.A. Mulder "Nuclear magnetic resonance-based determination of oxygen binding sites in protein cavities" Prot. Sci., 27(3) (2018) 769-779
  72. Kamil Tamiola, Ruud M. Scheek, Pieter van der Meulen & Frans A.A. Mulder "pepKalc - scalable and comprehensive calculation of electrostatic interactions in random coil polypeptides" Bioinformatics, 34(12) (2018) 2053-2060
  73. Jakob Toudahl Nielsen & Frans A.A. Mulder "POTENCI: Prediction of Temperature, Neighbor and pH-Corrected Chemical Shifts for Intrinsically Disordered Proteins" J. Biomol. NMR 70(3) (2018) 141-165
  74. Frans A.A. Mulder “Fuzzy and fast nuclear transport” J. Biol. Chem. 293(12) (2018) 4564-4565
  75. Falk Hoffmann, Frans A.A. Mulder & Lars V. Schäfer “Accurate methyl group dynamics in protein simulations with AMBER force fields” J. Chem. Phys. B 122(19) (2018) 5038-5048
  76. Martin Kurnik, Cagla Sahin, Camilla Bertel Andersen, Nikolai Lorenzen, Lise Giehm, Hossein Mohammad-Beigi,Christian Moestrup Jessen, Jan Skov Pedersen, Gunna Christiansen, Steen Vang Pedersen, Roland Staal, Girija Krishnamurthy, Keith Pitts, Peter H. Reinhart, Frans A.A. Mulder, Scot Mente,Warren D. Hirst, & Daniel Otzen "Novel α-synuclein aggregation inhibitors, identified by HTS, mainly target the monomeric state " Cell Chem Biol. (2018) e-pub ahead of print
  77. Falk Hoffmann, Mengjun Xue, Lars V. Schäfer & Frans A.A. Mulder "Narrowing the gap between experimental and computational determination of methyl group dynamics" Phys. Chem. Chem. Phys. 20 (2018) 24577 - 24590
  78. Rupashree Dass, Enrico Corlianò & Frans A.A. Mulder "Measurement of very fast exchange rates of individual amide protons in proteins by NMR spectroscopy" ChemPhysChem 20 (2019) 231-235
  79. Jakob T. Nielsen & Frans A.A. Mulder "Quality and bias of protein disorder predictors", Sci. Rep. 9(1) (2019) 5137
  80. Frans A.A. Mulder*, Leonardo Tenori & Claudio Luchinat "Fast and Quantitative NMR Metabolite Analysis Afforded by Paramagnetic Co-Solutes" Angewandte Chemie, in press (corresponding author)
  81. Mengjun Xue, Takuro Wakamoto, Camilla Kejlberg, Yuichi Yoshimura, Tania Aaquist Nielsen, Michael Wulff Risør, Kristian Wejse Sanggaard, Ryo Kitahara & Frans A.A. Mulder "How internal cavities destabilize a protein" Proc Natl Acad Sci USA, accepted
  82. Jakob T. Nielsen & Frans A.A. Mulder "Quantitative protein disorder assessment using NMR chemical shifts" Methods Mol Biol, (2019) accepted
  83. Rupashree Dass & Frans A.A. Mulder "Paris-DÉCOR: A protocol for the determination of fast protein backbone amide hydrogen exchange rates" Methods Mol Biol, (2019) accepted


 

ORCID: 0000-0001-9427-8406
ResearcherID: C-7158-2017

Thesis and Book Chapter Contributions

  1. Frans A.A. Mulder "NMR relaxation studies of protein dynamics in solution" Ph.D. Thesis (1998)
  2. Frans A.A. Mulder, Martin H. Lundqvist & Ruud M. Scheek "Nuclear Magnetic Resonance Spectroscopy Applied to (Intrinsically) Disordered Proteins" in: "Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation" V. Uversky and S. Longhi (Eds.) John Wiley and Sons Ltd, New Jersey (2010) pp. 61-87
  3. Frans A.A. Mulder & Ruud M. Scheek "Multidimensional NMR spectroscopy" in: "Encyclopedia of Biophysics" (G.C.K. Roberts Ed. in chief) Springer, Dordrecht, NL (2012) pp. 1637-1646
  4. Tobias Madl & Frans A.A. Mulder "Small paramagnetic co-solute molecules" in: Paramagnetism in Experimental Biomolecular NMR: New Developments in NMR Series" E. Ravera, G. Parigi, and C. Luchinat (Eds.) The Royal Society of Chemistry. (2018) ISBN 978-1-78801-086-3

 

PhD thesis supervision:

Mr. Renee Otten (Feb 2011) "Protein structure and dynamics by NMR: synergy between biochemistry and pulse sequence design"
Ms. Nur Alia Oktaviani (April 2014) "NMR studies of folded and unfolded proteins: method developments and biological insight"
Mr. Zebin Hong (co-supervisor; Sep 2015) "Structural Insights to the Natural Mechanisms for Activity Regulation of Matriptase"
Mr. Mats Holmberg (co-supervisor; Sep 2015) "Genetic factors and analysis of protein misfolding in vivo"
Mr. Kamil Tamiola (2019)
Ms. Camilla Bertel Andersen (co-supervisor; 2018)
Ms. Katrine Vogt Kristensen (co-supervisor; 2020)
Ms. Malene Selch Sønnichsen (2020)


Teaching:

Aarhus University BSc courses:

  • BioNMR (multidimensional NMR, protein structure and dynamics, theoretical and practical NMR spectroscopy, NMR in biology)
  • Biophysical chemistry (biomolecular structure, optical spectroscopies, NMR, kinetics, MS, chromatography and electrophoresis)
  • Introduction to medicinal chemistry (drug discovery, drug design, drug metabolism)

Aarhus University PhD course:

  • BioNanoTools coordinator (optical methods, spectroscopy, simulation, surface probe methods, mass spectronomy, bioinformatict, diffraction and scattering)

 

Managerial Skills and Leadership Development:

 

  • COST Action 15209 "European Network on NMR Relaxometry" Management Committee, representing Denmark
  • COST Action BM1405 "Non-globular proteins" Danish Management Committee substitute
  • Faculty of Science & Technology Internationalization Committee (2018–), member
  • TASSEP coordinator (2018-), Faculty of Science & Technology
  • iNANO Seminar Committee (2018–), member
  • Editorial Board for Journal of Biological Chemistry (2017–2021), member
  • Nanoscience PhD Committee (2017–2021), member
  • iNANO Social Committee (2016–), member
  • iNANO PhD Autumn School (2016–), organizer
  • Harvard Business School / Innovations Fund Denmark Pasteur Program “Leading the Virtual Company” (2015), completed
  • Aarhus University PhD Supervision Course (2014), completed
  • EMBO Laboratory Management Course “The Art of Leadership” (2012), completed
  • INPEC Representative for the Netherlands (2005–2011) & Denmark (2012–)

 

Course and workshop contributions

Contribution: "Dynamics in Disordered systems" Lecturer at the Swedish NMR Center "Protein Dynamics", Göteborg (SE), Oct 2019

Contribution: "NMR spectroscopy, a tool for the analysis of complex mixtures in various biological contexts", "International Workshop on Advanced Biomedical Technologies" Aarhus University (DK), Aug 2019

Contribution: "Using NMR relaxation to make NMR relaxation redundant" Telluride Science Research Center workshop on Protein Dynamics, Telluride (USA), July 2019

Telluride Science Research Center workshop on Protein Electrostatics, Telluride (USA), June 2019 declined

Participant: "NMR fingerprinting for metabolomics", University of Florence - CERM, Florence (IT), 11-14 Jun 2019

Session Chair: GIDRM discussion meeting "Metabolomics in Cancer", Florence (IT), 26-30 Nov 2018

Session Chair: ICMRBS 2018 Sattelite Workshop "Isotope-Labelling Approaches for Biomolecular NMR Spectroscopy", Dublin (IE), 19-24 Aug 2018

Contribution: "Accurate and individual side chain titration curves by NMR spectroscopy" Protein Electrostatics, Belgrade (RS), 23-30 June 2018

Contribution: "How and why internal cavities destabilize proteins" EMBO workshop Challenges for magnetic resonance in life sciences, Grosseto (IT), 27 May - 1 June 2018

Contribution: "NMR spectroscopy analysis of cellular metabolism", DANDRITE, Aarhus (DK), May 2018

Contribution, BISON course Dynamics of disordered proteins, Brno (CZ), 2-6 Sep 2017

Contribution, Protein electrostatics, Jyväskylä 27th Summer School, Jyväskylä (FI), 9-12 Aug 2017

Telluride Science Research Center workshop on Protein Dynamics, Telluride (USA), July 2017 declined

Telluride Science Research Center workshop on Protein Electrostatics, Telluride (USA), June 2017 declined

Contribution: "On the Microscopic Origin of the ‘Protein Dynamic Transition’: A Study combining Isotope Labelling, NMR Spectroscopy and Neutron Scattering", Advanced Isotope Labeling Methods for Integrative Structural Biology, Grenoble (FR), 3-10 Mar 2017

Compiled and taught PhD course "Biophysical Applications of NMR Spectroscopy" at Università degli Studi di Firenze (IT), Feb 2017

Co-organizer, member of scientific program committee & session chair: EUROMAR 2016 (600 participants), Aarhus (DK) 3-7 Jul 2016

Main organizer: Nordic NMR Network Meeting VI: Best practices in NMR pulse programs (20 participants), Aarhus (DK) 25-26 April 2016

Session chair & contribution: "Quantitative characterization of conformational protein disorder from NMR chemical shifts", TSRC Workshop on "Protein Dynamics", Les Houches (FR) 3-8 Apr 2016

Compiled and taught PhD course "Applications of advanced NMR spectroscopy" at Università degli Studi di Roma Tor Vergata (IT), Nov 2015 – Feb 2016

Main organizer: Telluride Science Research Center workshop on Protein Dynamics (30 participants), Telluride (USA), 1-9 Aug 2015

Contribution: "Detecting O2 binding to secluded protein cavities" Telluride Science Research Center workshop on Protein Dynamics, Telluride (USA), 1-9 Aug 2015

Telluride Science Research Center workshop on Protein Electrostatics, Telluride (USA), July 2015 declined

Contribution: "Protein Dynamics for Function", 14th CCPN Conference, Hull (UK) 1-3 Sep 2014

Contribution: "The Protein Dynamic Transition", Copenhagen summer school on Protein Dynamics (DK) Aug 2014

Contribution: "NMR spectroscopic investigation of pH-dependent PYP photocycle dynamics" TSRC Workshop on "Protein Dynamics", Les Houches (FR) 18-22 May 2014

Contribution: "Enzyme activity regulation by conformational entropy" Novo Nordisk - Chinese Academy of Sciences Workshop "Serine protease enzyme systems in health and disease", Guilin (CN), Oct 2013

Contribution: "Measurement and Modeling of Electrostatic Interactions in Disordered Proteins" CECAM workshop Intrinsically Disordered Proteins: Connecting Computation, Physics and Biology, Zurich (CH) Sept 2013

Contribution: "NMR spectroscopic investigation of pH-dependent PYP photocycle dynamics" Telluride Science Research Center Workshop on "Protein Dynamics" (USA) Aug 2013

Turkish NMR meeting, Istanbul (TU) Dec 2012 declined

Careers in Science. Insights from structural biologists. Max Perutz Laboratory, University of Vienna (AT), Sep 2012

ESF/EASRT-NMR workshop "Polarization Transfer between Water and Proteins" Laulasmaa, (EST) Mar 2012 declined

Contribution: "Moving targets. Studies of functional protein dynamics by NMR spectroscopy" International symposium Protein Dynamics and Function. NMR research towards drug design" Ritsumeikan University (JP), Jan 2012

Contribution: "NMR studies of protein dynamics" RRR workshop New Frontiers in NMR Spectroscopy, Tokyo (JP), Jan 2012

Contribution: "Isotope labeling approaches for protein dynamics studies by NMR spectroscopy and neutron scattering" Telluride Science Research Center workshop on Protein Dynamics, Telluride (USA), Aug 2011

Session Chair: IRB Barcelona BioMed Conference on Intrinsically Disordered Proteins in Biomedicine, Barcelona (ES), Oct 2010

Organizer: Workshop on NMR spectroscopy and neutron scattering to study protein dynamics, Sappey-en-Chartreuse (FR), Nov 2009

Session Chair & Contribution: "On the Protein Dynamic Transition. An NMR study", Telluride Science Research Center workshop on Protein Dynamics, Telluride (USA), Aug 2009

Contribution: "NMR techniques detect local structure in the disordered domain of autism-associated protein neuroligin-3" INSTRUCT workshop "Intrinsically Unfolded Proteins in Structural Biology", Hamburg (DE), Sep 2008

Contribution: "NMR approaches to resolve the resonance overlap problem for unfolded proteins: An application to the natively disordered cytoplasmic domain of human neuroligin-3", NMR-Life workshop "The application of NMR spectroscopy in studies of intrinsically disordered proteins, protein folding, aggregation and fibrillation", Copenhagen (DK), Dec 2007

Lecturer at the The Bijvoet-IMM Advanced NMR course "Experimental NMR relaxation methods", Utrecht (NL), 2007 / 2008 / 2009

Contribution: "NMR approaches to resolve the resonance overlap problem for unfolded proteins: An application to the natively disordered cytoplasmic domain of human neuroligin-3", EMBO/SPINE2 Workshop "Intrinsically Unfolded Proteins (IUPs): Biophysical Characterisation and Biological Significance", Budapest (HU), May 2007

Lecturer at the GBB masterclass on “Protein structures and protein structure-function relationships”, Groningen (NL), Jul 2005

Lecturer at the Swedish NMR Center "NMR data processing", Göteborg (SE), Oct 2003

 

Invited talks and promoted oral presentations

"How and why internal cavities destabilize proteins" Italian National Research Council IC-CNR, Trieste (IT), July 2019

"A tale of two intrinsically disordered proteins: How MOAG-4 promotes the aggregation of alpha-synuclein" Neuroscience Day 2019 "Brain Jam", Aarhus University (DK), May 2019

"A New NMR Technique to Measure Very Fast Hydrogen Exchange in Proteins: Do Protection Factors for Alpha-Synuclein Signal Structuration?" 60th Experimental Nuclear Magnetic Resonance Conference, Asilomar (US), April 2019

"How and why internal cavities destabilize proteins" Ecole Normale Supérieure, Paris (FR), Feb 2019

Danish NMR meeting (DK), 21-22 Jan 2019, session chair

"New tools for the study of IDPs and the structure determination of MOAG-4, an IDP that modulates in vivo protein aggregation, while remaining disordered upon binding." Aalborg University (DK), Dec 2018

"New tools for the study of IDPs and the structure determination of MOAG-4, an IDP that modulates in vivo protein aggregation, while remaining disordered upon binding." Copenhagen University (DK), 3-4 Dec 2018

"New computational tools to study Intrinsically Disordered Proteins" XXVIIIth ICMRBS, Dublin (IE), 19-24 Aug 2018

"How and why internal cavities destabilize proteins" The SCRIPPS Research Institute, La Jolla (CA), 19-30 Apr 2018

"Recent developments in protein NMR spectroscopy: from protein electrostatics to intrinsically disordered proteins and back again" Novo Nordisk, Måløv (DK), Mar 2018

"How and why internal cavities destabilize proteins" Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen (NL), 18-22 Oct 2017

"Protein unfolding under pressure" Bijvoet Center, University of Utrecht (NL), 18-22 Oct 2017

"Molecular dynamics studied by NMR spectroscopy: from methyl group rotation to intrinsically disorder proteins", University of Bologna, Bologna (IT), Jun 2017

"NMR spectroscopy, a tool for the analysis of complex mixtures in various biological contexts", University of Bolzano, Bolzano (IT), Jun 2017

"Protein NMR spectroscopy under pressure", Danish NMR Meeting, Nyborg (DK), Jan 2017

"Under pressure: The effect of cavities on protein stability", International Network of Protein Engineering Centers (INPEC) meeting, KAIST, Daejeon (PRK), Nov 2016

25th Anniversary of the Swedish NMR Center, Göteborg (SE), Oct 2016, cancelled

BioStruct Annual Conference, Jægtvolden (NO), Aug 2016, declined

"Quantitative characterization of conformational protein disorder from NMR chemical shifts", XXVIIth ICMRBS, Kyoto (JP), Aug 2016

"Quantitative characterization of conformational protein disorder from NMR chemical shifts", Chianti Workshop, Principina Terra (Grosseto) (IT), 5-10 Jun 2016

"Easy and unambiguous sequential assignments of intrinsically disordered proteins", IBS Grenoble (FR), Apr 2016

"Quantitative characterization of conformational protein disorder from NMR chemical shifts", University La Sapienza, Rome (IT), Feb 2016

Inauguration of NMR Center at NTNU Trondheim (NO), Dec 2015, declined

"Detecting O2 binding to secluded protein cavities", CERM Firenze (IT), Nov 2015

"Measurement and Modeling of Electrostatic Interactions in Disordered Proteins" Gordon Research Conference on Computational Aspects of Biomolecular NMR, Il Ciocco (IT), June 2015

"Measurement and Modeling of Electrostatic Interactions in Disordered Proteins" Danish NMR meeting, Lund (SE), Jan 2015

"Measurement and Modeling of Electrostatic Interactions in Disordered Proteins", Center for Molecular Protein Science, Lund University, Lund (SE), Jan 2015

“On the origin of the protein glass transition”, 3rd International Symposium on “Dynamical ordering of Biomolecular Systems for the Creation of Integrated Functions”, Mie (JP), Jan 2015

"NMR spectroscopic investigation of pH-dependent PYP photocycle dynamics", Symposium on Biomolecular Dynamics, Structure and NMR Spectroscopy, Grenoble (FR), Dec 2014

“Unambiguous sequential assignments by correlating the backbone chemical shifts of seven contiguous residues in a 3D spectrum” IDPbyNMR - High resolution tools to understand the functional role of protein intrinsic disorder, Riva del Sole (IT), Sept 2014

"An optimal paramagnetic relaxation agent for NMR spectroscopy of intrinsically disordered proteins" EUROMAR, Heraklion (GR), July 2013

"Quantitative characterization of conformational protein disorder" University of Copenhagen, Department of Biology, (DK), May 2013

"Quantitative characterization of conformational protein disorder" Leibniz Institute of Molecular Pharmacology (FMP) Berlin (DE), Mar 2013

"Where X-ray crystallography is blind, computation is inaccurate, but NMR excels" Bijvoet Center, Utrecht (NL), Oct 2012

"NMR chemical shifts and backbone scalar coupling experiments for the conformational characterization of disordered proteins", VIB Brussels (BE), Oct 2012

"Where X-ray crystallography is blind, computation is inaccurate, but NMR excels" Farewell symposium for Prof Sybren Wijmenga, Nijmegen (NL), Sep 2012

"NMR chemical shifts and backbone scalar coupling experiments for the conformational characterization of disordered proteins" National Centre for Biomolecular Research and CEITEC, Brno (CZ), Sep 2012

"NMR chemical shifts and backbone scalar coupling experiments for the conformational characterization of disordered proteins", Max Perutz Laboratory, University of Vienna (AT) Sep 2012

20th International Network of Protein Engineering Centers (INPEC) meeting “Engineering Protein - Systems, Functions and Applications”, Taipei (TW) Apr 2012, declined

"NMR experimental data to characterize residue specific structural propensity in intrinsically disordered proteins" Biochemical Society Focused Meeting on Intrinsically Disordered Proteins, York (UK), Mar 2012

"Protein dynamics on the nanometer and nanosecond scale. Uncovering the origin of the 'protein glass transition'" Distinguished iNANO lecture, Aarhus (DK), Mar 2012

"Isotope labeling approaches for protein dynamics studies by NMR spectroscopy and neutron scattering" Barcelona BioMed Conference on Macromolecular Dynamics, Barcelona (ES), Oct 2011

"Protein 'random coil' chemical shifts derived from intrinsically disordered proteins" Gordon Research Conference on Computational Aspects of Biomolecular NMR, Il Ciocco (IT), May 2011

"Studies of "invisible" protein states by relaxation dispersion NMR spectroscopy: The case of rapid ligand exchange from an internal cavity in mutant T4 lysozyme" 6th International Meeting on Biomolecules under Pressure, Otsu (JP), Mar 2011 meeting suspended

"Determination of protein side-chain conformations from 13C NMR chemical shifts: A reappraisal of the gamma-gauche effect", FGMR10, Gemeinschaft Deutsche Chemiker, Münster (DE), Sep 2010

"Insight into protein electrostatics from individual side chain pKa constants measured by NMR spectroscopy", Università degli Studi di Roma Tor Vergata, Roma (I), July 2010

"Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins", ENC, Daytona Beach (USA), Apr 2010

"Structuur en dynamica van eiwitten in vloeibaar en vast water" Nederlandse Vereniging voor Kristallografie, Dec 2009

"On the Protein Dynamic Transition. An NMR study", RMNeutron Workshop, Sappey-en-Chartreuse (FR), Nov 2009

"New opportunities for NMR studies of enzymes", National Synchrotron Light Source (BRA), Nov 2009

"New opportunities for NMR studies of enzymes", International Network of Protein Engineering Centers (INPEC) meeting, Itamambuca (BRA), Oct 2009

"Protein dynamics studied with neutron scattering and NMR spectroscopy", XXIème Congrès du GERM, Frejus (FR), Mar 2009

"Insight into protein electrostatics from individual side chain pKa constants measured by NMR spectroscopy", Institut de Biologie Structurale (IBS), Grenoble (FR), Jun 2008

"pKa determination of individual protein side chains by indirect 13C and 15N NMR", Annual Dutch meeting on Molecular and Cellular Biophysics, Veldhoven (NL), Oct 2007

"pKa determination of individual protein side chains by indirect 13C and 15N NMR", International Network of Protein Engineering Centres (INPEC), Jaca (ES), Jun 2007

"In search of the protein dynamic transition with neutron scattering and NMR spectroscopy", École normale supérieure Lyon (FR), Mar 2007

"In search of the protein dynamic transition with neutron scattering and NMR spectroscopy", Third Japanese-French seminar on structural dynamics of proteins, Grenoble (FR), Jan 2007

"In search of the protein dynamic transition with neutron scattering and NMR spectroscopy", Gordon Research Conference on Computational Aspects of Biomolecular NMR, Aussois (FR), Sep 2006

“New spins on protein dynamics using NMR spectroscopy” International Network of Protein Engineering Centres (INPEC) meeting, Ein Gedi (IL), Nov 2005

“Conformation and dynamics of protein L12 in solution and on the ribosome”, NMR-DG, Wageningen (NL), Oct 2005

“NMR experiments for protonation equilibria of amino acid sidechains in proteins”, Minisymposium on protein folding and interactions, Lund (SE), Sep 2005

 “Protein dynamics: from methyl group rotation to domain motion on the ribosome”, Institut de Biologie Structurale, Grenoble (FR), Aug 2004

“Conformation and dynamics of protein L12 in solution and on the ribosome”, SBNet meeting Tällberg (SE), Jun 2004

 


Active International collaborations

Prof. Dr. Claudio Luchinat, University of Florence (IT) NMR metabolomics

Prof. Dr. Sara Linse, Lund University (Sweden) Protein electrostatics, protein science   

Prof. Dr. Lewis E Kay, University of Toronto (Canada) NMR methodology

Prof. Dr. Joel Sussman, Weizmann Institute (Israel) Brain-derived proteins and IDPs

Dr. Martin Weik, IBS Grenoble (FR) Protein dynamics studied by biophysical techniques

Prof. Dr. M. Kataoka & Dr H. Kamikubo, NAIST, Nara (JP) Photoactive Yellow Protein

Prof. Dr. Daniel Otzen, Aarhus University (DK) Protein aggregation biophysics

Prof. Dr. Ryo Kitahara, Ritsumeikan University (JP) High-pressure NMR

Prof. Dr. Lars Schäfer, Ruhr-Universität Bochum (DE) Entropy, solvation and protein stability

 

 

 

 

Aarhus University PhD course:

  • BioNanoTools coordinator (optical methods, spectroscopy, simulation, surface probe methods, mass spectrometry, bioinformatics, diffraction and scattering)