Flemming Winther Bach

The effect of Normast (PEA) on neuropathic pain in spinal cord injury

Publikation: KonferencebidragPosterForskning

Neuropathic pain and spasticity after spinal cord injury (SCI) represent still a significant, unresolved problem causing suffering and re¬duced quality of life in patients with SCI.
Treatment of neuropathic pain is a complex and difficult task, and many patients have incom¬plete relief from present available and recom¬mended treatment.
Palmitoylethanolamide (PEA) is a fatty acid which is produced in many cells in the body. It suggested to potentiate the body’s own canna¬bis-like substances (endocannabinoids) and to reduce pain and inflammation.
Clinical trials support the use of PEA on neuro¬pathic pain. So far no studies have been pub¬lished looking at the effect of PEA on neuro¬pathic pain in patients with SCI.
Normast is a medical supplement, which con¬tains PEA and is approved for use in Denmark.
The primary aim is to investigate the effect of Normast (PEA) on neuropathic pain, and sec¬ondary to study the effect of Normast on spas¬ticity and psychological functioning in patients with spinal cord injury.
Population characteristics:
Gender, male/female, n 43/15
Age since inclusion, years, mean (SD) 55.3 (9.5)
Time since injury, years, mean (SD) 8.8 (8.9)
Present status:
Presently, 66 patients (74% male) are included of which 55 have completed the trial. Of those included, 5% have complete tetraplegia, 39% incomplete tetraplegia, 29% complete paraplegia and 27% incomplete paraplegia. Average age at inclusion is 55.3 (±9.5) years and average time since injury is 8.8 (±8.9) years.
Causes of injury are 29% transport, 26% fall, 25% unspecified or unknown, 16% other traumatic causes and 4% sports injuries. No major side effects have been reported.
The study was financially supported by Region Midtjyllands Sundhedsvidenskabelige Forskningsfond, Hospitalsenheden Midts forskningspulje and PTU. Epitech Group SLR supported by providing Normast and placebo.
Udgivelsesår23 jan. 2015
StatusUdgivet - 23 jan. 2015

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