Flemming Winther Bach

Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. / Celicanin, Marko; Blaabjerg, Mia; Maersk-Moller, Camilla Charlotte; Beniczky, Sandor; Marner, L; Thomsen, Christine; Bach, Flemming Winther Bach; Kondziella, Daniel; Andersen, Henning; Somnier, Finn; Illes, Zsolt; Pinborg, Lars Hageman.

I: European Journal of Neurology, Bind 24, Nr. 8, 08.2017, s. 999-1005.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Celicanin, M, Blaabjerg, M, Maersk-Moller, CC, Beniczky, S, Marner, L, Thomsen, C, Bach, FWB, Kondziella, D, Andersen, H, Somnier, F, Illes, Z & Pinborg, LH 2017, 'Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study', European Journal of Neurology, bind 24, nr. 8, s. 999-1005. https://doi.org/10.1111/ene.13324

APA

Celicanin, M., Blaabjerg, M., Maersk-Moller, C. C., Beniczky, S., Marner, L., Thomsen, C., ... Pinborg, L. H. (2017). Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. European Journal of Neurology, 24(8), 999-1005. https://doi.org/10.1111/ene.13324

CBE

Celicanin M, Blaabjerg M, Maersk-Moller CC, Beniczky S, Marner L, Thomsen C, Bach FWB, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH. 2017. Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. European Journal of Neurology. 24(8):999-1005. https://doi.org/10.1111/ene.13324

MLA

Vancouver

Celicanin M, Blaabjerg M, Maersk-Moller CC, Beniczky S, Marner L, Thomsen C o.a. Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. European Journal of Neurology. 2017 aug;24(8):999-1005. https://doi.org/10.1111/ene.13324

Author

Celicanin, Marko ; Blaabjerg, Mia ; Maersk-Moller, Camilla Charlotte ; Beniczky, Sandor ; Marner, L ; Thomsen, Christine ; Bach, Flemming Winther Bach ; Kondziella, Daniel ; Andersen, Henning ; Somnier, Finn ; Illes, Zsolt ; Pinborg, Lars Hageman. / Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. I: European Journal of Neurology. 2017 ; Bind 24, Nr. 8. s. 999-1005.

Bibtex

@article{23d7765e982642659f83cd582598f9ac,
title = "Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study",
abstract = "BACKGROUND AND PURPOSE: The aim of this study was to describe clinical and paraclinical characteristics of all Danish patients who tested positive for anti-voltage-gated potassium channels (VGKC)-complex, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-contactin-associated protein-2 antibodies in the serum/cerebrospinal fluid between 2009 and 2013 with follow-up interviews in 2015 and 2016.METHODS: We evaluated antibody status, symptoms leading to testing, course of disease, suspected diagnosis and time of admission as well as diagnosis and treatment. All magnetic resonance imaging, electroencephalography and 18 F-fluorodeoxyglucose positron emission tomography scans were re-evaluated by experts in the field.RESULTS: A total of 28/192 patients tested positive for VGKC-complex antibodies by radioimmunoassay and indirect immunofluorescence; 17 had antibodies to LGI1 and 6/7 of the available cerebrospinal fluids from these patients were seropositive. These 17 patients all had a clinical phenotype appropriate to LGI1 antibodies. The remaining 11 were LGI1 negative (n = 4) or not tested (n = 7). Of these, two had a phenotype consistent with limbic encephalitis. The remaining phenotypes were Guillain-Barr{\'e} syndrome, Creutzfeldt-Jakob disease, neuromyotonia and anti-N-methyl-D-aspartate receptor encephalitis. Magnetic resonance imaging abnormalities were demonstrated in 69{\%} of the LGI1-positive patients. Two patients with normal magnetic resonance imaging demonstrated temporal lobe hypermetabolism using 18 F-fluorodeoxyglucose positron emission tomography. Abnormal electroencephalography recordings were found in 86{\%} of the patients. Upon follow-up (median 3.2 years), the median modified Rankin Scale score of anti-LGI1-positive patients was 2 and only two patients reported seizures in the past year.CONCLUSIONS: Patients diagnosed with anti-LGI1 autoimmune encephalitis increased significantly from 2009 to 2014, probably due to increased awareness. In contrast to seropositive anti-VGKC-complex patients, all anti-LGI1-positive patients presented with a classical limbic encephalitis. The majority of patients recovered well.",
keywords = "Journal Article",
author = "Marko Celicanin and Mia Blaabjerg and Maersk-Moller, {Camilla Charlotte} and Sandor Beniczky and L Marner and Christine Thomsen and Bach, {Flemming Winther Bach} and Daniel Kondziella and Henning Andersen and Finn Somnier and Zsolt Illes and Pinborg, {Lars Hageman}",
note = "{\circledC} 2017 EAN.",
year = "2017",
month = "8",
doi = "10.1111/ene.13324",
language = "English",
volume = "24",
pages = "999--1005",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study

AU - Celicanin, Marko

AU - Blaabjerg, Mia

AU - Maersk-Moller, Camilla Charlotte

AU - Beniczky, Sandor

AU - Marner, L

AU - Thomsen, Christine

AU - Bach, Flemming Winther Bach

AU - Kondziella, Daniel

AU - Andersen, Henning

AU - Somnier, Finn

AU - Illes, Zsolt

AU - Pinborg, Lars Hageman

N1 - © 2017 EAN.

PY - 2017/8

Y1 - 2017/8

N2 - BACKGROUND AND PURPOSE: The aim of this study was to describe clinical and paraclinical characteristics of all Danish patients who tested positive for anti-voltage-gated potassium channels (VGKC)-complex, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-contactin-associated protein-2 antibodies in the serum/cerebrospinal fluid between 2009 and 2013 with follow-up interviews in 2015 and 2016.METHODS: We evaluated antibody status, symptoms leading to testing, course of disease, suspected diagnosis and time of admission as well as diagnosis and treatment. All magnetic resonance imaging, electroencephalography and 18 F-fluorodeoxyglucose positron emission tomography scans were re-evaluated by experts in the field.RESULTS: A total of 28/192 patients tested positive for VGKC-complex antibodies by radioimmunoassay and indirect immunofluorescence; 17 had antibodies to LGI1 and 6/7 of the available cerebrospinal fluids from these patients were seropositive. These 17 patients all had a clinical phenotype appropriate to LGI1 antibodies. The remaining 11 were LGI1 negative (n = 4) or not tested (n = 7). Of these, two had a phenotype consistent with limbic encephalitis. The remaining phenotypes were Guillain-Barré syndrome, Creutzfeldt-Jakob disease, neuromyotonia and anti-N-methyl-D-aspartate receptor encephalitis. Magnetic resonance imaging abnormalities were demonstrated in 69% of the LGI1-positive patients. Two patients with normal magnetic resonance imaging demonstrated temporal lobe hypermetabolism using 18 F-fluorodeoxyglucose positron emission tomography. Abnormal electroencephalography recordings were found in 86% of the patients. Upon follow-up (median 3.2 years), the median modified Rankin Scale score of anti-LGI1-positive patients was 2 and only two patients reported seizures in the past year.CONCLUSIONS: Patients diagnosed with anti-LGI1 autoimmune encephalitis increased significantly from 2009 to 2014, probably due to increased awareness. In contrast to seropositive anti-VGKC-complex patients, all anti-LGI1-positive patients presented with a classical limbic encephalitis. The majority of patients recovered well.

AB - BACKGROUND AND PURPOSE: The aim of this study was to describe clinical and paraclinical characteristics of all Danish patients who tested positive for anti-voltage-gated potassium channels (VGKC)-complex, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-contactin-associated protein-2 antibodies in the serum/cerebrospinal fluid between 2009 and 2013 with follow-up interviews in 2015 and 2016.METHODS: We evaluated antibody status, symptoms leading to testing, course of disease, suspected diagnosis and time of admission as well as diagnosis and treatment. All magnetic resonance imaging, electroencephalography and 18 F-fluorodeoxyglucose positron emission tomography scans were re-evaluated by experts in the field.RESULTS: A total of 28/192 patients tested positive for VGKC-complex antibodies by radioimmunoassay and indirect immunofluorescence; 17 had antibodies to LGI1 and 6/7 of the available cerebrospinal fluids from these patients were seropositive. These 17 patients all had a clinical phenotype appropriate to LGI1 antibodies. The remaining 11 were LGI1 negative (n = 4) or not tested (n = 7). Of these, two had a phenotype consistent with limbic encephalitis. The remaining phenotypes were Guillain-Barré syndrome, Creutzfeldt-Jakob disease, neuromyotonia and anti-N-methyl-D-aspartate receptor encephalitis. Magnetic resonance imaging abnormalities were demonstrated in 69% of the LGI1-positive patients. Two patients with normal magnetic resonance imaging demonstrated temporal lobe hypermetabolism using 18 F-fluorodeoxyglucose positron emission tomography. Abnormal electroencephalography recordings were found in 86% of the patients. Upon follow-up (median 3.2 years), the median modified Rankin Scale score of anti-LGI1-positive patients was 2 and only two patients reported seizures in the past year.CONCLUSIONS: Patients diagnosed with anti-LGI1 autoimmune encephalitis increased significantly from 2009 to 2014, probably due to increased awareness. In contrast to seropositive anti-VGKC-complex patients, all anti-LGI1-positive patients presented with a classical limbic encephalitis. The majority of patients recovered well.

KW - Journal Article

U2 - 10.1111/ene.13324

DO - 10.1111/ene.13324

M3 - Journal article

C2 - 28544133

VL - 24

SP - 999

EP - 1005

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 8

ER -