Ellen Margrethe Hauge

Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study

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DOI

  • A Scharmga, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
  • ,
  • K K Keller
  • M Peters, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
  • ,
  • A van Tubergen, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
  • ,
  • J P van den Bergh, Department of Internal Medicine, Viecuri Medical Center, Venlo, The Netherlands.
  • ,
  • B van Rietbergen, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • ,
  • R Weijers, European Society Radiology, Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
  • ,
  • D Loeffen, European Society Radiology, Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
  • ,
  • E M Hauge
  • P Geusens, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium. piet.geusens@scarlet.be.

We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multiplane HR-pQCT images. Four 3-mm thick portions in three anatomic metacarpophalangeal joint specimens were selected for histologic sectioning. First, VCs identified with HR-pQCT were examined for confirmation on histology. Second and independently, VCs identified by histology were matched to single and multiplane HR-pQCT images to assess for presence of cortical interruptions. Only one out of five cortical interruptions suggestive for VC on HR-pQCT could be confirmed on histology. In contrast, 52 VCs were identified by histology of which 39 (75%) could be classified as cortical interruption or periosteal excavation on matched single HR-pQCT slices. On multiplane HR-pQCT images, 11 (21%) showed a cortical interruption in at least two consecutive slices in two planes, 36 (69%) in at least one slice in two planes and five (10%) showed no cortical interruption. Substantially more VCs were present in histology sections than initially suggested by HR-pQCT. The small size and heterogeneous presentation, limit the identification as VC on HR-pQCT.

OriginalsprogEngelsk
Artikelnummer8966
TidsskriftScientific Reports
Vol/bind7
Nummer1
Antal sider7
ISSN2045-2322
DOI
StatusUdgivet - 21 aug. 2017

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