Ellen Margrethe Hauge

Changes in Bone Marrow Adipose Tissue One Year After Roux-en-Y Gastric Bypass: A Prospective Cohort Study

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  • jbmr.3814

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DOI

  • Ingvild Kristine Blom-Høgestøl, University of Oslo, Universitetet i Oslo
  • ,
  • Tom Mala, University of Oslo
  • ,
  • Jon A. Kristinsson, University of Oslo
  • ,
  • Ellen Margrethe Hauge
  • Cathrine Brunborg, University of Oslo
  • ,
  • Hanne Løvdal Gulseth, University of Oslo, Norwegian Institute of Public Health
  • ,
  • Erik Fink Eriksen, University of Oslo, Universitetet i Oslo

Bone marrow adipose tissue (BMAT) has been postulated to mediate skeletal fragility in type 2 diabetes (T2D) and obesity. Roux-en-Y gastric bypass (RYGB) induces a substantial weight loss and resolution of comorbidities. However, the procedure induces increased bone turnover and fracture rates. No previous study has evaluated biopsy-measured BMAT fraction preoperatively and after RYGB. In this study, we aimed to investigate BMAT fraction of the hip in participants with and without T2D preoperatively and 1 year after RYGB and explore factors associated with BMAT change. Patients with morbid obesity scheduled for RYGB were examined preoperatively and 1 year after RYGB. Forty-four participants were included and preoperative examinations were possible in 35. Of these, 33 (94%) met for follow-up, 2 were excluded, and BMAT estimation was not possible in 1. Eighteen (60%) of the participants were females and 11 (37%) had T2D. Preoperative BMAT fraction was positively associated with glycosylated hemoglobin and negatively associated with areal bone mineral density (aBMD). After RYGB, BMAT fraction decreased from 40.4 ± 1.7% to 35.6 ± 12.8%, p = 0.042, or with mean percent change of 10.7% of preoperative BMAT fraction. Change in BMAT fraction was positively associated with change in body mass index (BMI) and total body fat. In females, we observed a mean percent reduction of 22.4 ± 19.6%, whereas in males BMAT increased with a mean percent of 6.8 ± 37.5%, p = 0.009. For males, changes in estradiol were associated with BMAT change; this was not observed for females. In participants with and without T2D, the mean percent BMAT reduction was 5.8 ± 36.9% and 13.5 ± 28.0%, respectively, p = 0.52. We conclude that a high BMAT seems to be associated with lower aBMD and poorer glycemic control in obese subjects. After RYGB, we observed a significant decrease in BMAT. The reduction in BMAT did not differ between participants with and without T2D, but appeared sex specific.

OriginalsprogEngelsk
TidsskriftJournal of Bone and Mineral Research
Vol/bind34
Nummer10
Sider (fra-til)1815-1823
Antal sider9
ISSN0884-0431
DOI
StatusUdgivet - 1 okt. 2019

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