Institut for Biomedicin

Ditte Demontis

No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

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No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. / Nyegaard, Mette; Demontis, Ditte; Thestrup, Britta Boserup; Hedemand, Anne; Sørensen, Karina Meden; Hansen, Thomas; Werge, Thomas; Hougaard, David Michael; Yolken, Robert H; Mortensen, Preben Bo; Mors, Ole; Børglum, Anders D.

I: Psychiatric Genetics, Bind 22, Nr. 3, 2012, s. 146-8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Author

Nyegaard, Mette ; Demontis, Ditte ; Thestrup, Britta Boserup ; Hedemand, Anne ; Sørensen, Karina Meden ; Hansen, Thomas ; Werge, Thomas ; Hougaard, David Michael ; Yolken, Robert H ; Mortensen, Preben Bo ; Mors, Ole ; Børglum, Anders D. / No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. I: Psychiatric Genetics. 2012 ; Bind 22, Nr. 3. s. 146-8.

Bibtex

@article{0b36117fbde5490eb6b550b1267d72c7,
title = "No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia",
abstract = "The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.",
author = "Mette Nyegaard and Ditte Demontis and Thestrup, {Britta Boserup} and Anne Hedemand and S{\o}rensen, {Karina Meden} and Thomas Hansen and Thomas Werge and Hougaard, {David Michael} and Yolken, {Robert H} and Mortensen, {Preben Bo} and Ole Mors and B{\o}rglum, {Anders D}",
year = "2012",
doi = "10.1097/YPG.0b013e328353953c",
language = "English",
volume = "22",
pages = "146--8",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "3",

}

RIS

TY - JOUR

T1 - No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

AU - Nyegaard, Mette

AU - Demontis, Ditte

AU - Thestrup, Britta Boserup

AU - Hedemand, Anne

AU - Sørensen, Karina Meden

AU - Hansen, Thomas

AU - Werge, Thomas

AU - Hougaard, David Michael

AU - Yolken, Robert H

AU - Mortensen, Preben Bo

AU - Mors, Ole

AU - Børglum, Anders D

PY - 2012

Y1 - 2012

N2 - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.

AB - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.

U2 - 10.1097/YPG.0b013e328353953c

DO - 10.1097/YPG.0b013e328353953c

M3 - Journal article

C2 - 22495247

VL - 22

SP - 146

EP - 148

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 3

ER -