Institut for Biomedicin

Ditte Demontis

Genetic markers of ADHD-related variations in intracranial volume

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Genetic markers of ADHD-related variations in intracranial volume. / Klein, Marieke; Walters, Raymond K.; Demontis, Ditte; Stein, Jason L.; Hibar, Derrek P.; Adams, Hieab H.; Bralten, Janita; Mota, Nina Roth; Schachar, Russell; Sonuga-Barke, Edmund; Mattheisen, Manuel; Neale, Benjamin M.; Thompson, Paul M.; Medland, Sarah E.; Børglum, Anders D.; Faraone, Stephen V.; Arias-Vasquez, Alejandro; Franke, Barbara.

I: American Journal of Psychiatry, Bind 176, Nr. 3, 2019, s. 228-238.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Klein, M, Walters, RK, Demontis, D, Stein, JL, Hibar, DP, Adams, HH, Bralten, J, Mota, NR, Schachar, R, Sonuga-Barke, E, Mattheisen, M, Neale, BM, Thompson, PM, Medland, SE, Børglum, AD, Faraone, SV, Arias-Vasquez, A & Franke, B 2019, 'Genetic markers of ADHD-related variations in intracranial volume', American Journal of Psychiatry, bind 176, nr. 3, s. 228-238. https://doi.org/10.1176/appi.ajp.2018.18020149

APA

Klein, M., Walters, R. K., Demontis, D., Stein, J. L., Hibar, D. P., Adams, H. H., Bralten, J., Mota, N. R., Schachar, R., Sonuga-Barke, E., Mattheisen, M., Neale, B. M., Thompson, P. M., Medland, S. E., Børglum, A. D., Faraone, S. V., Arias-Vasquez, A., & Franke, B. (2019). Genetic markers of ADHD-related variations in intracranial volume. American Journal of Psychiatry, 176(3), 228-238. https://doi.org/10.1176/appi.ajp.2018.18020149

CBE

Klein M, Walters RK, Demontis D, Stein JL, Hibar DP, Adams HH, Bralten J, Mota NR, Schachar R, Sonuga-Barke E, Mattheisen M, Neale BM, Thompson PM, Medland SE, Børglum AD, Faraone SV, Arias-Vasquez A, Franke B. 2019. Genetic markers of ADHD-related variations in intracranial volume. American Journal of Psychiatry. 176(3):228-238. https://doi.org/10.1176/appi.ajp.2018.18020149

MLA

Klein, Marieke o.a.. "Genetic markers of ADHD-related variations in intracranial volume". American Journal of Psychiatry. 2019, 176(3). 228-238. https://doi.org/10.1176/appi.ajp.2018.18020149

Vancouver

Klein M, Walters RK, Demontis D, Stein JL, Hibar DP, Adams HH o.a. Genetic markers of ADHD-related variations in intracranial volume. American Journal of Psychiatry. 2019;176(3):228-238. https://doi.org/10.1176/appi.ajp.2018.18020149

Author

Klein, Marieke ; Walters, Raymond K. ; Demontis, Ditte ; Stein, Jason L. ; Hibar, Derrek P. ; Adams, Hieab H. ; Bralten, Janita ; Mota, Nina Roth ; Schachar, Russell ; Sonuga-Barke, Edmund ; Mattheisen, Manuel ; Neale, Benjamin M. ; Thompson, Paul M. ; Medland, Sarah E. ; Børglum, Anders D. ; Faraone, Stephen V. ; Arias-Vasquez, Alejandro ; Franke, Barbara. / Genetic markers of ADHD-related variations in intracranial volume. I: American Journal of Psychiatry. 2019 ; Bind 176, Nr. 3. s. 228-238.

Bibtex

@article{ba813f4c6c964912ad8629219acca57f,
title = "Genetic markers of ADHD-related variations in intracranial volume",
abstract = " Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder. Methods: The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level. Results: Analyses revealed a significant negative genetic correlation between ADHD and ICV (r g =20.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variation in neurite outgrowth-related genes. Conclusions: This is the first genome-wide study to show significant genetic overlap between brain volume measures and ADHD, both on the global and the single variant level. Variants linked to smaller ICV were associated with increased ADHD risk. These findings can help us develop new hypotheses about biological mechanisms by which brain structure alterations may be involved in ADHD disease etiology. ",
author = "Marieke Klein and Walters, {Raymond K.} and Ditte Demontis and Stein, {Jason L.} and Hibar, {Derrek P.} and Adams, {Hieab H.} and Janita Bralten and Mota, {Nina Roth} and Russell Schachar and Edmund Sonuga-Barke and Manuel Mattheisen and Neale, {Benjamin M.} and Thompson, {Paul M.} and Medland, {Sarah E.} and B{\o}rglum, {Anders D.} and Faraone, {Stephen V.} and Alejandro Arias-Vasquez and Barbara Franke",
year = "2019",
doi = "10.1176/appi.ajp.2018.18020149",
language = "English",
volume = "176",
pages = "228--238",
journal = "The American Journal of Psychiatry (Spanish Edition)",
issn = "1139-3475",
publisher = "Grupo Ars XXI de Comunicacion, SA",
number = "3",

}

RIS

TY - JOUR

T1 - Genetic markers of ADHD-related variations in intracranial volume

AU - Klein, Marieke

AU - Walters, Raymond K.

AU - Demontis, Ditte

AU - Stein, Jason L.

AU - Hibar, Derrek P.

AU - Adams, Hieab H.

AU - Bralten, Janita

AU - Mota, Nina Roth

AU - Schachar, Russell

AU - Sonuga-Barke, Edmund

AU - Mattheisen, Manuel

AU - Neale, Benjamin M.

AU - Thompson, Paul M.

AU - Medland, Sarah E.

AU - Børglum, Anders D.

AU - Faraone, Stephen V.

AU - Arias-Vasquez, Alejandro

AU - Franke, Barbara

PY - 2019

Y1 - 2019

N2 - Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder. Methods: The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level. Results: Analyses revealed a significant negative genetic correlation between ADHD and ICV (r g =20.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variation in neurite outgrowth-related genes. Conclusions: This is the first genome-wide study to show significant genetic overlap between brain volume measures and ADHD, both on the global and the single variant level. Variants linked to smaller ICV were associated with increased ADHD risk. These findings can help us develop new hypotheses about biological mechanisms by which brain structure alterations may be involved in ADHD disease etiology.

AB - Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder. Methods: The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level. Results: Analyses revealed a significant negative genetic correlation between ADHD and ICV (r g =20.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variation in neurite outgrowth-related genes. Conclusions: This is the first genome-wide study to show significant genetic overlap between brain volume measures and ADHD, both on the global and the single variant level. Variants linked to smaller ICV were associated with increased ADHD risk. These findings can help us develop new hypotheses about biological mechanisms by which brain structure alterations may be involved in ADHD disease etiology.

UR - http://www.scopus.com/inward/record.url?scp=85062890841&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.2018.18020149

DO - 10.1176/appi.ajp.2018.18020149

M3 - Journal article

C2 - 30818988

AN - SCOPUS:85062890841

VL - 176

SP - 228

EP - 238

JO - The American Journal of Psychiatry (Spanish Edition)

JF - The American Journal of Psychiatry (Spanish Edition)

SN - 1139-3475

IS - 3

ER -