Ditte Demontis

Functional Insight From Fruit Flies on Human ADHD Candidate Genes

Publikation: Bidrag til bog/antologi/rapport/proceedingKonferencebidrag i proceedingsForskning

Standard

Functional Insight From Fruit Flies on Human ADHD Candidate Genes. / Rohde, Palle Duun; Demontis, Ditte; Arvidson, Sandra Marie Neumann; Madsen, Lisbeth Strøm; Loeschcke, Volker; Sørensen, Peter; Børglum, Anders; Kristensen, Torsten Nygaard.

Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala, 2015. s. 35.

Publikation: Bidrag til bog/antologi/rapport/proceedingKonferencebidrag i proceedingsForskning

Harvard

Rohde, PD, Demontis, D, Arvidson, SMN, Madsen, LS, Loeschcke, V, Sørensen, P, Børglum, A & Kristensen, TN 2015, Functional Insight From Fruit Flies on Human ADHD Candidate Genes. i Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala, s. 35, 17th IBANGS Meeting 2015, Uppsala, Sverige, 19/05/2015.

APA

Rohde, P. D., Demontis, D., Arvidson, S. M. N., Madsen, L. S., Loeschcke, V., Sørensen, P., Børglum, A., & Kristensen, T. N. (2015). Functional Insight From Fruit Flies on Human ADHD Candidate Genes. I Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society (s. 35).

CBE

Rohde PD, Demontis D, Arvidson SMN, Madsen LS, Loeschcke V, Sørensen P, Børglum A, Kristensen TN. 2015. Functional Insight From Fruit Flies on Human ADHD Candidate Genes. I Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala. s. 35.

MLA

Rohde, Palle Duun o.a.. "Functional Insight From Fruit Flies on Human ADHD Candidate Genes". Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala. 2015, 35.

Vancouver

Rohde PD, Demontis D, Arvidson SMN, Madsen LS, Loeschcke V, Sørensen P o.a. Functional Insight From Fruit Flies on Human ADHD Candidate Genes. I Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala. 2015. s. 35

Author

Rohde, Palle Duun ; Demontis, Ditte ; Arvidson, Sandra Marie Neumann ; Madsen, Lisbeth Strøm ; Loeschcke, Volker ; Sørensen, Peter ; Børglum, Anders ; Kristensen, Torsten Nygaard. / Functional Insight From Fruit Flies on Human ADHD Candidate Genes. Genes, Brain, and Behavior 2015: 17th Annual Meeting of the International Behavioural and Neural Genetics Society. Uppsala, 2015. s. 35

Bibtex

@inproceedings{7f19be1f67f64b76b659f120fa8f53ed,
title = "Functional Insight From Fruit Flies on Human ADHD Candidate Genes",
abstract = "Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder emerging in early childhood with an average prevalence rate of 5% in children and 3.7% in adults. ADHD is characterized by inattention, impulsivity and hyperactivity. This, combined with educational and social dysfunctions, and increased risk of mentalcomorbidities, makes ADHD a disorder with high individual and societal costs. We use Drosophila melanogaster as a model to investigate the phenotypic consequences of gene disruption of 14 genes with human orthologs,selected by their proposed contribution to increased risk of developing ADHD. We use Minos mutants, where target genes have been disrupted by the Minos transposable element, to test the effect on locomotor activity.By measuring the distance traveled, we find disparity in locomotor activity between control and Minos mutants. Impaired dopamine system underlies the majority of ADHD symptoms, and effective treatment is achieved withamphetamines. We fed flies with either 1.5 mg/ml dexamphetamine dissolved in 5% w/w sucrose or a 5% w/w sucrose solution. Treatment with dexamphetamine increased activity of controls and some Minos lines, and decreased activity levels for other mutants. Decreased activity level, when treated with dexamphetamine, is seen when using other ADHD animal models. Our findings suggest involvement of the proposed candidate genes Genes, Brain, and Behavior 2015 36 Talk Abstracts in hyperactivity in D. melanogaster, providing functional evidence for their association with ADHD. Additional studies investigating conditional gene inactivation using UAS-GAL4 systems will further elucidate the importance of the investigated genes.",
author = "Rohde, {Palle Duun} and Ditte Demontis and Arvidson, {Sandra Marie Neumann} and Madsen, {Lisbeth Str{\o}m} and Volker Loeschcke and Peter S{\o}rensen and Anders B{\o}rglum and Kristensen, {Torsten Nygaard}",
year = "2015",
month = may,
day = "19",
language = "English",
pages = "35",
booktitle = "Genes, Brain, and Behavior 2015",
note = "null ; Conference date: 19-05-2015 Through 22-05-2015",

}

RIS

TY - GEN

T1 - Functional Insight From Fruit Flies on Human ADHD Candidate Genes

AU - Rohde, Palle Duun

AU - Demontis, Ditte

AU - Arvidson, Sandra Marie Neumann

AU - Madsen, Lisbeth Strøm

AU - Loeschcke, Volker

AU - Sørensen, Peter

AU - Børglum, Anders

AU - Kristensen, Torsten Nygaard

PY - 2015/5/19

Y1 - 2015/5/19

N2 - Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder emerging in early childhood with an average prevalence rate of 5% in children and 3.7% in adults. ADHD is characterized by inattention, impulsivity and hyperactivity. This, combined with educational and social dysfunctions, and increased risk of mentalcomorbidities, makes ADHD a disorder with high individual and societal costs. We use Drosophila melanogaster as a model to investigate the phenotypic consequences of gene disruption of 14 genes with human orthologs,selected by their proposed contribution to increased risk of developing ADHD. We use Minos mutants, where target genes have been disrupted by the Minos transposable element, to test the effect on locomotor activity.By measuring the distance traveled, we find disparity in locomotor activity between control and Minos mutants. Impaired dopamine system underlies the majority of ADHD symptoms, and effective treatment is achieved withamphetamines. We fed flies with either 1.5 mg/ml dexamphetamine dissolved in 5% w/w sucrose or a 5% w/w sucrose solution. Treatment with dexamphetamine increased activity of controls and some Minos lines, and decreased activity levels for other mutants. Decreased activity level, when treated with dexamphetamine, is seen when using other ADHD animal models. Our findings suggest involvement of the proposed candidate genes Genes, Brain, and Behavior 2015 36 Talk Abstracts in hyperactivity in D. melanogaster, providing functional evidence for their association with ADHD. Additional studies investigating conditional gene inactivation using UAS-GAL4 systems will further elucidate the importance of the investigated genes.

AB - Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder emerging in early childhood with an average prevalence rate of 5% in children and 3.7% in adults. ADHD is characterized by inattention, impulsivity and hyperactivity. This, combined with educational and social dysfunctions, and increased risk of mentalcomorbidities, makes ADHD a disorder with high individual and societal costs. We use Drosophila melanogaster as a model to investigate the phenotypic consequences of gene disruption of 14 genes with human orthologs,selected by their proposed contribution to increased risk of developing ADHD. We use Minos mutants, where target genes have been disrupted by the Minos transposable element, to test the effect on locomotor activity.By measuring the distance traveled, we find disparity in locomotor activity between control and Minos mutants. Impaired dopamine system underlies the majority of ADHD symptoms, and effective treatment is achieved withamphetamines. We fed flies with either 1.5 mg/ml dexamphetamine dissolved in 5% w/w sucrose or a 5% w/w sucrose solution. Treatment with dexamphetamine increased activity of controls and some Minos lines, and decreased activity levels for other mutants. Decreased activity level, when treated with dexamphetamine, is seen when using other ADHD animal models. Our findings suggest involvement of the proposed candidate genes Genes, Brain, and Behavior 2015 36 Talk Abstracts in hyperactivity in D. melanogaster, providing functional evidence for their association with ADHD. Additional studies investigating conditional gene inactivation using UAS-GAL4 systems will further elucidate the importance of the investigated genes.

M3 - Article in proceedings

SP - 35

BT - Genes, Brain, and Behavior 2015

CY - Uppsala

Y2 - 19 May 2015 through 22 May 2015

ER -