Ditte Demontis

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. / Demontis, Ditte; Walters, Raymond K.; Martin, Joanna; Mattheisen, Manuel; Als, Thomas D.; Agerbo, Esben; Baldursson, Gísli; Belliveau, Rich; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Churchhouse, Claire; Dumont, Ashley; Eriksson, Nicholas; Gandal, Michael; Goldstein, Jacqueline I.; Grasby, Katrina L.; Grove, Jakob; Gudmundsson, Olafur O.; Hansen, Christine S.; Hauberg, Mads Engel; Hollegaard, Mads V.; Howrigan, Daniel P.; Huang, Hailiang; Maller, Julian B.; Martin, Alicia R.; Martin, Nicholas G.; Moran, Jennifer; Pallesen, Jonatan; Palmer, Duncan S.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Poterba, Timothy; Poulsen, Jesper Buchhave; Ripke, Stephan; Robinson, Elise B.; Satterstrom, F. Kyle; Stefansson, Hreinn; Stevens, Christine; Turley, Patrick; Walters, G. Bragi; Won, Hyejung; Wright, Margaret J.; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team ; Dalsgaard, Søren; Mors, Ole; Mortensen, Preben Bo; Børglum, Anders D.

I: Nature Genetics, Bind 51, 2019, s. 63–75.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Demontis, D, Walters, RK, Martin, J, Mattheisen, M, Als, TD, Agerbo, E, Baldursson, G, Belliveau, R, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Cerrato, F, Chambert, K, Churchhouse, C, Dumont, A, Eriksson, N, Gandal, M, Goldstein, JI, Grasby, KL, Grove, J, Gudmundsson, OO, Hansen, CS, Hauberg, ME, Hollegaard, MV, Howrigan, DP, Huang, H, Maller, JB, Martin, AR, Martin, NG, Moran, J, Pallesen, J, Palmer, DS, Pedersen, CB, Pedersen, MG, Poterba, T, Poulsen, JB, Ripke, S, Robinson, EB, Satterstrom, FK, Stefansson, H, Stevens, C, Turley, P, Walters, GB, Won, H, Wright, MJ, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Dalsgaard, S, Mors, O, Mortensen, PB & Børglum, AD 2019, 'Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder', Nature Genetics, bind 51, s. 63–75. https://doi.org/10.1038/s41588-018-0269-7

APA

Demontis, D., Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., Belliveau, R., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Cerrato, F., Chambert, K., Churchhouse, C., Dumont, A., Eriksson, N., Gandal, M., Goldstein, J. I., Grasby, K. L., Grove, J., ... Børglum, A. D. (2019). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51, 63–75. https://doi.org/10.1038/s41588-018-0269-7

CBE

Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Dalsgaard S, Mors O, Mortensen PB, Børglum AD. 2019. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. 51:63–75. https://doi.org/10.1038/s41588-018-0269-7

MLA

Vancouver

Author

Demontis, Ditte ; Walters, Raymond K. ; Martin, Joanna ; Mattheisen, Manuel ; Als, Thomas D. ; Agerbo, Esben ; Baldursson, Gísli ; Belliveau, Rich ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Marie ; Cerrato, Felecia ; Chambert, Kimberly ; Churchhouse, Claire ; Dumont, Ashley ; Eriksson, Nicholas ; Gandal, Michael ; Goldstein, Jacqueline I. ; Grasby, Katrina L. ; Grove, Jakob ; Gudmundsson, Olafur O. ; Hansen, Christine S. ; Hauberg, Mads Engel ; Hollegaard, Mads V. ; Howrigan, Daniel P. ; Huang, Hailiang ; Maller, Julian B. ; Martin, Alicia R. ; Martin, Nicholas G. ; Moran, Jennifer ; Pallesen, Jonatan ; Palmer, Duncan S. ; Pedersen, Carsten Bøcker ; Pedersen, Marianne Giørtz ; Poterba, Timothy ; Poulsen, Jesper Buchhave ; Ripke, Stephan ; Robinson, Elise B. ; Satterstrom, F. Kyle ; Stefansson, Hreinn ; Stevens, Christine ; Turley, Patrick ; Walters, G. Bragi ; Won, Hyejung ; Wright, Margaret J. ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC) ; Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium ; 23andMe Research Team ; Dalsgaard, Søren ; Mors, Ole ; Mortensen, Preben Bo ; Børglum, Anders D. / Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. I: Nature Genetics. 2019 ; Bind 51. s. 63–75.

Bibtex

@article{5a9cf9d44ced4063ba398856a92eabbb,
title = "Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder",
abstract = "Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.",
author = "Ditte Demontis and Walters, {Raymond K.} and Joanna Martin and Manuel Mattheisen and Als, {Thomas D.} and Esben Agerbo and G{\'i}sli Baldursson and Rich Belliveau and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Felecia Cerrato and Kimberly Chambert and Claire Churchhouse and Ashley Dumont and Nicholas Eriksson and Michael Gandal and Goldstein, {Jacqueline I.} and Grasby, {Katrina L.} and Jakob Grove and Gudmundsson, {Olafur O.} and Hansen, {Christine S.} and Hauberg, {Mads Engel} and Hollegaard, {Mads V.} and Howrigan, {Daniel P.} and Hailiang Huang and Maller, {Julian B.} and Martin, {Alicia R.} and Martin, {Nicholas G.} and Jennifer Moran and Jonatan Pallesen and Palmer, {Duncan S.} and Pedersen, {Carsten B{\o}cker} and Pedersen, {Marianne Gi{\o}rtz} and Timothy Poterba and Poulsen, {Jesper Buchhave} and Stephan Ripke and Robinson, {Elise B.} and Satterstrom, {F. Kyle} and Hreinn Stefansson and Christine Stevens and Patrick Turley and Walters, {G. Bragi} and Hyejung Won and Wright, {Margaret J.} and {ADHD Working Group of the Psychiatric Genomics Consortium (PGC)} and {Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium} and {23andMe Research Team} and S{\o}ren Dalsgaard and Ole Mors and Mortensen, {Preben Bo} and B{\o}rglum, {Anders D.}",
year = "2019",
doi = "10.1038/s41588-018-0269-7",
language = "English",
volume = "51",
pages = "63–75",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

AU - Demontis, Ditte

AU - Walters, Raymond K.

AU - Martin, Joanna

AU - Mattheisen, Manuel

AU - Als, Thomas D.

AU - Agerbo, Esben

AU - Baldursson, Gísli

AU - Belliveau, Rich

AU - Bybjerg-Grauholm, Jonas

AU - Bækvad-Hansen, Marie

AU - Cerrato, Felecia

AU - Chambert, Kimberly

AU - Churchhouse, Claire

AU - Dumont, Ashley

AU - Eriksson, Nicholas

AU - Gandal, Michael

AU - Goldstein, Jacqueline I.

AU - Grasby, Katrina L.

AU - Grove, Jakob

AU - Gudmundsson, Olafur O.

AU - Hansen, Christine S.

AU - Hauberg, Mads Engel

AU - Hollegaard, Mads V.

AU - Howrigan, Daniel P.

AU - Huang, Hailiang

AU - Maller, Julian B.

AU - Martin, Alicia R.

AU - Martin, Nicholas G.

AU - Moran, Jennifer

AU - Pallesen, Jonatan

AU - Palmer, Duncan S.

AU - Pedersen, Carsten Bøcker

AU - Pedersen, Marianne Giørtz

AU - Poterba, Timothy

AU - Poulsen, Jesper Buchhave

AU - Ripke, Stephan

AU - Robinson, Elise B.

AU - Satterstrom, F. Kyle

AU - Stefansson, Hreinn

AU - Stevens, Christine

AU - Turley, Patrick

AU - Walters, G. Bragi

AU - Won, Hyejung

AU - Wright, Margaret J.

AU - ADHD Working Group of the Psychiatric Genomics Consortium (PGC)

AU - Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium

AU - 23andMe Research Team

AU - Dalsgaard, Søren

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - Børglum, Anders D.

PY - 2019

Y1 - 2019

N2 - Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

AB - Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

UR - http://www.scopus.com/inward/record.url?scp=85057436335&partnerID=8YFLogxK

U2 - 10.1038/s41588-018-0269-7

DO - 10.1038/s41588-018-0269-7

M3 - Journal article

C2 - 30478444

AN - SCOPUS:85057436335

VL - 51

SP - 63

EP - 75

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -