Ditte Demontis

Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Stacy Steinberg
  • ,
  • Simone de Jong
  • ,
  • Ole A Andreassen
  • ,
  • Thomas Werge
  • ,
  • Anders D Børglum
  • Ole Mors
  • Preben B Mortensen
  • Omar Gustafsson
  • ,
  • Javier Costas
  • ,
  • Olli P H Pietiläinen
  • ,
  • Ditte Demontis
  • Sergi Papiol
  • ,
  • Johanna Huttenlocher
  • ,
  • Manuel Mattheisen
  • ,
  • René Breuer
  • ,
  • Evangelos Vassos
  • ,
  • Ina Giegling
  • ,
  • Gillian Fraser
  • ,
  • Nicholas Walker
  • ,
  • Annamari Tuulio-Henriksson
  • ,
  • Jaana Suvisaari
  • ,
  • Jouko Lönnqvist
  • ,
  • Tiina Paunio
  • ,
  • Ingrid Agartz
  • ,
  • Ingrid Melle
  • ,
  • Srdjan Djurovic
  • ,
  • Eric Strengman
  • ,
  • Gesche Jürgens
  • ,
  • Birte Glenthøj
  • ,
  • Lars Terenius
  • ,
  • David M Hougaard
  • ,
  • Torben Orntoft
  • ,
  • Carsten Wiuf, Danmark
  • Michael Didriksen
  • ,
  • Mads V Hollegaard, Danmark
  • Merete Nordentoft
  • ,
  • Ruud van Winkel
  • ,
  • Gunter Kenis
  • ,
  • Lilia Abramova
  • ,
  • Vasily Kaleda
  • ,
  • Manuel Arrojo
  • ,
  • Julio Sanjuán
  • ,
  • Celso Arango
  • ,
  • Swetlana Sperling
  • ,
  • Moritz Rossner
  • ,
  • Michele Ribolsi
  • ,
  • Valentina Magni
  • ,
  • Alberto Siracusano
  • ,
  • Claus Christiansen
  • ,
  • Lambertus A Kiemeney
  • ,
  • Irish Schizophrenia Genomics Consortium
  • Institut for Human Genetik
  • Center for psykiatrisk forskning
  • Center for Registerforskning
  • Center for Bioinformatik (BiRC)
Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
OriginalsprogEngelsk
TidsskriftHuman Molecular Genetics
Vol/bind20
Nummer20
Sider (fra-til)4076-81
ISSN0964-6906
DOI
StatusUdgivet - 26 jul. 2011

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