Research in the field of Space Life Sciences

Real Weightlessness

• 12th DLR parabolic flight campaign, Bordeaux Merignac, France , 4/2008
• 13th DLR parabolic flight campaign, Bordeaux Merignac, France, 2/2009
• 14th DLR parabolic flight campaign, Cologne, Germany, 9/2009

Simulated Weightlessness

• Random Positioning Machine
• Rotating Wall Vessel

Publications/Original Papers:

A First/Senior Author

1. Grimm D, Bauer J, Schönberger J. Blockade of neoangiogenesis, a new and promising technique to control the growth of malignant tumors and its metastases. Current Vascular Pharmacology accepted for publication
2. Grimm D, Infanger M, Westphal K, Ulbrich C, Pietsch J, Kossmehl P, Vadrucci S, Baatout S, Flick B, Paul M, Bauer J. A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Engineering 2009 in press
3. Grosse J*, Grimm D*, Westphal K, Ulbrich C, Moosbauer J, Pohl F, Koelbl O, Infanger M, Eilles C, Schoenberger, J. Radiolabeled annexin V for imaging apoptosis in radiated human follicular thyroid carcinomas - is an individualized protocol necessary).  Nuclear Medicine and Biology 2009 in press +equal contribution
4. Ulbrich C, Westphal K, Baatout S, Wehland M, Bauer J, Flick B, Infanger M, Kreutz R, Vadrucci S, Egli M, Cogoli A, Derradji H, Pietsch J, Paul M, Grimm D. Effects of basic fibroblast growth factor n endothelial cells under conditions of simulated microgravity. J Cell Biochem. 2008 Feb 5; [Epub ahead of print]
5. Infanger M, Grosse J, Westphal K, Leder A, Ulbrich C, Paul M, Grimm D. Vascular Endothelial Growth Factor induces extracellular matrix proteins and osteopontin in the umbilical artery.  Ann Vasc Surg. 2008 Mar;22(2):273-84.
6. Infanger M, Grimm D. Meniscus and Discus lesions of Triangular Fibrocartilage Complex (TFCC): Treatment by laser-assisted wrist arthroscopy. J Plast Reconstr Aesthet Surg. 2008 May 9. [Epub ahead of print]
7. Infanger M, Faramarzi S, Grosse J, Kurth E, Ulbrich C, Bauer J, Wehland M, Kreutz R, Kossmehl P, Paul M, Grimm D. Expression of Vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia-reperfusion injury. Cardiovascular Pathology 2007;16:291-299
8. Infanger M, Kossmehl P, Shakibaei M, Bauer J, Kossmehl-Zorn S, Cogoli A, Curcio F, Oksche A, Wehland M, Kreutz R, Paul M, Grimm D. Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells. Cell and Tissue Res 2006;324:267-77.
9. Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, Küster S, Spain S, Paul M, Grimm D. Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. J Cell Biochem. 2007 Aug 15;101(6):1439-55.
10. Infanger M, Kossmehl P, Shakibaei M, Baatout S, Bauer J, Grosse J, Witzing A, Cogoli A, Faramarzi S, Derradji H, Neefs M, Paul M, Grimm D. Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity. Impact of vascular endothelial growth factor. Apoptosis 2006;11:749-64.
11. Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, Danser AHJ, Grosse J, Paul M, Grimm D. Mechanisms of apoptosis after ischemia and reperfusion: Role of the Renin-Angiotensin System. Apoptosis 2006;11:347-58.
12. Infanger M, Baum E, Grimm D, Ertel W. Palmar Reduction And Internal Fixation For Displaced Intraarticular fractures of the radius with locking compression plate: Operative strategy leads to functional treatment J. Orthopaedics. 2006;3(3)e12
13. Kossmehl P, Schönberger J, Shakibaei M, Faramarzi S, Kurth E, Habighorst B, von Bauer R, Wehland M, Kreutz R, Infanger M, Schulze-Tanzil G, Paul M, Grimm D. Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion. J Mol Med 2005 Aug;83(8):626-37.
14. Infanger M, Shakibaei M, Kossmehl P, Hollenberg SM, Grosse J, Faramarzi S, Schulze-Tanzil G, Paul M, Grimm D. Intraluminal application of VEGF enhances healing of microvascular anastomosis in a rat model. J Vasc Res 2005;42:202-13.
15. Obermaier C, Jankowski V, Schmutzler C, Bauer J, Wildgruber R, Infanger M, Köhrle J, Krause E, Weber G, Grimm D. Improved Sample Preparation for Free Flow-Isoelectric Focusing: Identification of Human Thyroid Cancer Cell Proteins. Electrophoresis 2005;26:2109-16.
16. Schoenberger J+, Grimm D+, Kossmehl P, Infanger M, Kurth E, Eilles C. Effects of PTK787/ZK222584 a tyrosine kinase inhibitor on the growth of a poorly differentiated thyroid carcinoma. An animal study. Endocrinology 2004;145:1031-8. (+JS and DG contributed equally)
17. Infanger M, Schmidt O, Kossmehl P, Grad S, Ertel W, Grimm D. Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema. Burns 2004;30:305-11.
18. Kossmehl P, Shakibaei M, Cogoli A, Infanger M, Curcio F, Schönberger J, Eilles C, Bauer J, Pickenhahn H, Schulze-Tanzil G, Paul M, Grimm D. Weightlessness-induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology 2003;9:4172-9.
19. Grimm D, Kossmehl P, Jabusch HC, Krämer BK, Fredersorf S, Kromer EP. Experimental diabetes and left ventricular hypertrophy. Effects of beta-receptor blockade. Cardiovascular Pathology 2002;11:229-37.
20. Grimm D, Bauer J, Kossmehl P, Shakibaei M, Schoenberger J, Pickenhahn H, Schulze-Tanzil G, Vetter R, Eilles C, Paul M, Cogoli A. Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid thyroid carcinoma cells. FASEB J 2002;16:604-6.
21. Rothermund L, Kreutz R, Kossmehl P, Fredersdorf S, Shakibaei M, Schulze-Tanzil G, Paul M, Grimm D. Early onset of chondroitin sulfate and osteopontin expression in Angiotensin II-dependent left ventricular hypertrophy. Am J of Hypertension 2002;15:644-52.
22. Grimm D, Huber M, Jabusch HC, Shakibaei M, Fredersdorf S, Paul M, Riegger GAJ, Kromer EP. Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload. Effects of beta-receptor blockade. J Mol Cell Cardiol 2001;33:487-501.
23. Schönberger J, Bauer J, Weber G, Spruß T, Paul M, Eilles C, Grimm D. Establishment and characterization of a human thyroid carcinoma cell line ML-1. J Mol Med 2000:78:102-10.
24. Grimm D, Holmer SR, Riegger GAJ, Kromer EP. Effects of beta-receptor blockade and Angiotensin II type₁ receptor antagonism in isoproterenol-induced heart failure in the rat. Cardiovascular Pathol 1999;8:315-23.
25. Grimm D, Kromer EP. Growth hormone and interstitial fibrosis. Cardiovascular Res 1999;43:254.
26. Grimm D, Elsner D, Schunkert H, Pfeifer M, Griese D, Bruckschlegel G, Muders F, Riegger GA, Kromer EP. Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. Cardiovasc Res 1998;37(1):91-100.
27. Grimm D, Cameron D, Griese DP, Riegger GA, Kromer EP. Differential effects of growth hormone on cardiomyocyte and extracellular matrix protein remodeling following experimental myocardial infarction. Cardiovasc Res 1998;40:297-306.
28. Grimm D, Kromer EP, Bruckschlegel G, Böcker W, Holmer SR, Riegger GAJ, Schunkert H. Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: contribution of the renin-angiotensin system. J Hypertens 1998;16:1345-55.
29. Grimm D, Bauer J, Hofstädter F, Riegger G, Kromer EP. Characteristics of multicellular spheroids formed by primary cultures of human thyroid tumor cells. Thyroid 1997;7:859-65.
30. Grimm D, Bauer J, Kromer E, Steinbach P, Riegger G, Hofstädter F. Human follicular and papillary thyroid carcinoma cells interact differently with human venous endothelial cells. Thyroid 1995;5:155-64.
31. Grimm D, Hofstädter F, Bauer J, Spruss T, Steinbach P, Bernhardt G, Menze R. Establishment and characterization of a human papillary thyroid carcino-ma cell line with oxyphilic differentiation (ONCO-DG 1). Virchows Arch. B Cell Pathol. Incl. Mol Pathol 1992;62:97-104.
32. Hofstädter F, Knüchel R, Grimm D. Multicellular tumor spheroids-A test model for studies of antitumor drugs. Arch. Pharm 1990;328:538.

B Co-Author:

1. Schulz A, Schlesener M, Weiss J, Hänsch J, Wendt N, Kossmehl P, Grimm D, Vetter R, Kreutz R. The protective effect of female gender on the development of albuminuria in a polygenetic rat model is further enhanced by replacement of a major autosomal QTL. Clin Sci (Lond). 2008 Feb;114(4):305-11.
2. Wendt N, Schulz A, Siegel AK, Weiss J, Wehland M, Sietmann A, Kossmehl P, Grimm D, Stoll M, Kreutz R. Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats. J Hypertens. 2007;25:95-102.
3. Schulz A, Weiss J, Schlesener M, Wehland M, Wendt N, Kossmehl P, Anika Sietmann A, Grimm D, Stoll M, Randel Nyengaard J, Kreutz R. The development of overt proteinuria in the MWF rat is suppressed by replacement of chromosome 6 in a consomic rat strain. J Am Soc Nephro, 2007;18:113-121
4. Rothermund L, Nierhaus M, Fialkowski O, Freese F, Ibscher R, Mieschel S, Kossmehl P, Grimm D, Wehland M, Kreutz R. Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis. J Hypertens 2006;24:1857-64.
5. Nogueira AC, Ast I, Patone G, Perschel FH, Grimm D, Paul M. Functional effects of acute coronary occlusion and catecholaminergic stimuli on the isolated normothermic hemoperfused porcine heart. Clinical and Experimental Hypertension 2003;25:235-55.
6. Kammerl MC, Grimm D, Kromer EP, Jabusch HC, Reif R, Morhard S, Endemann D, M. Fischereder M, Riegger GAJ, Krämer BK. Effects of aortic stenosis on renal renin, angiotensin receptor, endothelin and NOS gene expression in rats. Am J Nephrol 2002;22:84-9.
7. Riecke K, Grimm D, Shakibaei M, Kossmehl P, Schulze-Tanzil G, Paul M, Stahlmann R. Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin increase transforming growth factor ß and cause myocardial fibrosis in marmosets (Callithrix jacchus). Arch Toxicol 2002;76:360-66.
8. Schönberger J, Rüschoff J, Grimm D, Marienhagen J, Rümmele P, Meyringer R, Kossmehl P, Hofstädter F, Eilles C. Glucose transporter 1 (glut1) gene expression is related to thyroid neoplasms with an unfavorable prognosis. An immunohistochemical study. Thyroid 2002;12:747-54.
9. Weber G, Grimm D, Bauer J. Application of binary buffer systems to free flow cell electrophoresis. Electrophoresis 2000;21:325-8.
10. Kammerl M, Grimm D, Nabel C, Schweda F, Bach M, Fredersdorf S, Piehler H, Holmer SR, Riegger GAJ, Kromer EP, Krämer BK. Effects of growth hormone on renal renin gene expression in normal rats and rats with myocardial infarction. Nephrology Dialysis Transplantation 2000;15:786-90.
11. Böcker W, Hupf H, Grimm D, Kurzidim K, Schunkert H. Effects of indipamide in rats with pressure overload left ventricular hypertrophy. J of Cardiovasc Pharmacol 2000;36:481-6.
12. Hupf H, Grimm D, Riegger GAJ, Schunkert H. Evidence for a vasopressin system in the rat heart. Circ Res 1999;84:365-70.
13. Bruckschlegel G, Holmer SR, Jandeleit K, Grimm D, Muders F, Kromer EP, Riegger GAJ, Schunkert H. Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats. Hypertension 1995;25:250-9.
14. Nicolai H, Steinbach P, Knuechel-Clarke R, Grimm D, Roessler W, Wieland WF, Hofstaedter F. Proliferation of tumor spheroids after shock-wave treatment. J. Cancer Res Clin Oncol 1994;120:438-41.
15. Bauer J, Grimm D, Hofstädter F, Wieland W. Techniques for studies on growth characteristics of human prostatic cancer cells. Biotechnol. Prog 1992;8:494-500.
16. Schafferhans K, Heidbreder E, Grimm D, Heidland A. Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat. Klin. Wochenschr 1986;64 Suppl 6: 73-7. (bis 1992 Klinische Wochenschrift, 1992-1994 Clinical Investigator, seit 1994 J Mol Med)
17. Schafferhans K, Heidbreder E, Grimm D, Heidland A. Norepinephrine-induced acute renal failure: beneficial effects of atrial natriuretic factor. Nephron 1986;44: 240-4. (seit 2003 Nephron Experimental Nephrology)

C Other published papers:

Case Reports

1. Infanger M, Kossmehl P, Grimm D. Successful microsurgical primary replantation of an amputated cheek. Acta Otolaryngol 2006;126:432-4.
2. Infanger M, Kossmehl P, Grimm D. Surgical and medical management of rare echinococcosis of the extremities: pre- and post-operative long-term chemotherapy. Scand J Infect Dis 2005;37:954-7.

Reviews published in peer-reviewed journals

1. Grimm D, Bauer J, Infanger M, Cogoli A. The use of the random positioning machine for the study of gravitational effects on signal transduction in mammalian cells. Signal Transduction. 2006; 6:388-396.
2. Schoenberger J, Bauer J, Moosbauer J, Eilles C, Grimm D. Innovative strategies in in vivo apoptosis imaging. Curr Med Chem. 2008;15(2):187-94.