Christoffer Laustsen

Phd, Lektor

Christoffer Laustsen
Institut for Klinisk Medicin - The MR Research Centre
Palle Juul Jensens boulevard 99
8200, Aarhus N
Danmark
E-mail: cl@clin.au.dk
Telefon: 78456139

Publikationer

Stødkilde-Jørgensen, H, Laustsen, C, Hansen, ESS, Schulte, R, Ardenkjaer-Larsen, JH, Comment, A, Frøkiaer, J, Ringgaard, S, Bertelsen, LB, Ladekarl, M & Weber, B 2019, 'Pilot Study Experiences With Hyperpolarized [1-13 C]pyruvate MRI in Pancreatic Cancer Patients', Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.26888
Hansen, RB, Sánchez-Heredia, JD, Bøgh, N, Hansen, ESS, Laustsen, C, Hanson, LG & Ardenkjaer-Larsen, JH 2019, 'Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.27892
Omann, C, Agger, P, Bøgh, N, Laustsen, C, Ringgaard, S, Stephenson, RS, Anderson, RH, Hjortdal, VE & Smerup, M 2019, 'Resolving the natural myocardial remodelling brought upon by cardiac contraction; a porcine ex-vivo cardiovascular magnetic resonance study of the left and right ventricle', Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, bind 21, 35. https://doi.org/10.1186/s12968-019-0547-2
Laustsen, C, Lipsø, K, Østergaard, JA, Nielsen, PM, Bertelsen, LB, Flyvbjerg, A, Pedersen, M, Palm, F & Ardenkjær-Larsen, JH 2019, 'High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes', Tomography - A Journal for Imaging Research, bind 5, nr. 2, s. 239-247. https://doi.org/10.18383/j.tom.2019.00003
Agger, P, Hyldebrandt, JA, Hansen, ESS, Omann, C, Bøgh, N, Waziri, F, Nielsen, PM & Laustsen, C 2019, 'Magnetic resonance hyperpolarization imaging detects early myocardial dysfunction in a porcine model of right ventricular heart failure', European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jez074
Tougaard, RS, Szocska Hansen, ES, Laustsen, C, Nørlinger, TS, Mikkelsen, E, Lindhardt, J, Nielsen, PM, Bertelsen, LB, Schroeder, M, Bøtker, HE, Kim, WY, Wiggers, H & Stødkilde-Jørgensen, H 2019, 'Hyperpolarized [1-13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model', Magnetic Resonance in Medicine, bind 81, nr. 4, s. 2655-2665. https://doi.org/10.1002/mrm.27560
Faarkrog Høyer, K, Laustsen, C, Ringgaard, S, Qi, H, Mariager, CØ, Nielsen, TS, Sundekilde, UK, Treebak, JT, Jessen, N & Stødkilde-Jørgensen, H 2019, 'Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS', Journal of Endocrinology, bind 242, nr. 3, s. 251-260. https://doi.org/10.1530/JOE-19-0159
Mariager, CØ, Lindhardt, J, Nielsen, PM, Schulte, RF, Ringgaard, S & Laustsen, C 2019, 'Fractional Perfusion: A Simple Semi-Parametric Measure for Hyperpolarized C-13 MR', IEEE Transactions on Radiation and Plasma Medical Sciences, bind 3, nr. 4, s. 523-527. https://doi.org/10.1109/TRPMS.2019.2905724
Wang, Z, Nielsen, PM, Laustsen, C & Bertelsen, LB 2019, 'Metabolic consequences of lactate dehydrogenase inhibition by oxamate in hyperglycemic proximal tubular cells', Experimental Cell Research, bind 378, nr. 1, s. 51-56. https://doi.org/10.1016/j.yexcr.2019.03.001
Kjaergaard, U, Laustsen, C, Nørlinger, T, Tougaard, RS, Mikkelsen, E, Qi, H, Bertelsen, LB, Jessen, N & Stødkilde-Jørgensen, H 2018, 'Hyperpolarized [1-13 C] pyruvate as a possible diagnostic tool in liver disease', Physiological Reports, bind 6, nr. 23, s. e13943. https://doi.org/10.14814/phy2.13943
Qi, H, Mariager, CØ, Nielsen, PM, Schroeder, M, Lindhardt, J, Nørregaard, R, Klein, JD, Sands, JM & Laustsen, C 2018, 'Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature', NMR in Biomedicine, s. e4028. https://doi.org/10.1002/nbm.4028
Sanchez-Heredia, JD, Johansen, DH, Hansen, RB, Szocska Hansen, ES, Laustsen, C, Zhurbenko, V & Ardenkjaer-Larsen, JH 2018, 'Improved Decoupling for Low Frequency MRI Arrays using Non-conventional Preamplifier Impedance', IEEE transactions on bio-medical engineering. https://doi.org/10.1109/TBME.2018.2881203
Tougaard, RS, Hansen, ESS, Laustsen, C, Lindhardt, J, Schroeder, M, Bøtker, HE, Kim, WY, Wiggers, H & Stødkilde-Jørgensen, H 2018, 'Acute hypertensive stress imaged by cardiac hyperpolarized [1-C]pyruvate magnetic resonance', Magnetic Resonance in Medicine, bind 80, nr. 5, s. 2053-2061. https://doi.org/10.1002/mrm.27164
Miller, JJ, Lau, AZ, Nielsen, PM, McMullen-Klein, G, Lewis, AJ, Jespersen, NR, Ball, V, Gallagher, FA, Carr, CA, Laustsen, C, Bøtker, HE, Tyler, DJ & Schroeder, MA 2018, 'Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis', J A C C: Cardiovascular Imaging, bind 11, nr. 11, s. 1594-1606. https://doi.org/10.1016/j.jcmg.2017.09.020
Shokouh, P, Jeppesen, PB, Hermansen, K, Laustsen, C, Stødkilde-Jørgensen, H, Hamilton-Dutoit, SJ, Søndergaard Schmedes, M, Qi, H, Stokholm Nørlinger, T & Gregersen, S 2018, 'Effects of Unfiltered Coffee and Bioactive Coffee Compounds on the Development of Metabolic Syndrome Components in a High-Fat-/High-Fructose-Fed Rat Model', Nutrients, bind 10, nr. 10. https://doi.org/10.3390/nu10101547
Miller, JJ, Grist, JT, Serres, S, Larkin, JR, Lau, AZ, Ray, K, Fisher, KR, Hansen, E, Tougaard, RS, Nielsen, PM, Lindhardt, J, Laustsen, C, Gallagher, FA, Tyler, DJ & Sibson, N 2018, '13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI', Scientific Reports, bind 8, nr. 1, s. 15082. https://doi.org/10.1038/s41598-018-33363-5
Riis-Vestergaard, MJ, Breining, P, Pedersen, SB, Laustsen, C, Stødkilde-Jørgensen, H, Borghammer, P, Jessen, N & Richelsen, B 2018, 'Evaluation of active brown adipose tissue by the use of hyperpolarized [1-13C]pyruvate MRI in mice', International Journal of Molecular Sciences, bind 19, nr. 9, 2597. https://doi.org/10.3390/ijms19092597
Lipsø, KW, Hansen, ESS, Tougaard, RS, Laustsen, C & Ardenkjaer-Larsen, JH 2018, 'Dynamic coronary MR angiography in a pig model with hyperpolarized water', Magnetic Resonance in Medicine, bind 80, nr. 3, s. 1165-1169. https://doi.org/10.1002/mrm.27088
Bertelsen, LB, Nielsen, PM, Qi, H, Mariager, CØ, Lindhardt, J & Laustsen, C 2018, 'Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI', Tomography - A Journal for Imaging Research, bind 4, nr. 3, s. 105-109. https://doi.org/10.18383/j.tom.2018.00022
Mikkelsen, EFR, Mariager, CØ, Nørlinger, T, Qi, H, Schulte, RF, Jakobsen, S, Frøkiær, J, Pedersen, M, Stødkilde-Jørgensen, H & Laustsen, C 2018, 'Publisher Correction: Hyperpolarized [1-C]-acetate Renal Metabolic Clearance Rate Mapping', Scientific Reports, bind 8, nr. 1, s. 11235. https://doi.org/10.1038/s41598-018-29057-7
Van Erp, AC, Rebolledo, RA, Hoeksma, D, Jespersen, NR, Ottens, PJ, Nørregaard, R, Pedersen, M, Laustsen, C, Burgerhof, JGM, Wolters, JC, Ciapaite, J, Bøtker, HE, Leuvenink, HGD & Jespersen, B 2018, 'Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys', Scientific Reports, bind 8, nr. 1, s. 4405. https://doi.org/10.1038/s41598-018-22689-9
Qi, H, Mariager, CØ, Lindhardt, J, Nielsen, PM, Stødkilde-Jørgensen, H & Laustsen, C 2018, 'Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.27165
Liao, D, Gregersen, H, Agger, P, Laustsen, C, Ringgaard, S, Stødkilde-Jørgensen, H & Zhao, J 2018, '3D reconstruction and fiber quantification in the pig lower esophageal sphincter region using in vitro diffusion tensor imaging', Biomedical Physics & Engineering Express, bind 4.
Shokouh, P, Jeppesen, PB, Hermansen, K, Nørskov, NP, Laustsen, C, Jacques Hamilton-Dutoit, S, Qi, H, Stødkilde-Jørgensen, H & Gregersen, S 2018, 'A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome', Nutrients, bind 10, nr. 1, 6. https://doi.org/10.3390/nu10010006
Qi, H, Nielsen, PM, Schroeder, M, Bertelsen, LB, Palm, F & Laustsen, C 2018, 'Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats', Diabetologia, bind 61, nr. 2, s. 445-454. https://doi.org/10.1007/s00125-017-4445-6
Mariager, CØ, Nielsen, PM, Qi, H, Ringgaard, S & Laustsen, C 2018, 'Hyperpolarized 13 C,15 N2 -urea T2 relaxation changes in acute kidney injury', Magnetic Resonance in Medicine, bind 80, nr. 2, s. 696-702. https://doi.org/10.1002/mrm.27050
Agger, P, Ilkjær, C, Laustsen, C, Smerup, M, Frandsen, JR, Ringgaard, S, Pedersen, M, Partridge, JB, Anderson, RH & Hjortdal, V 2017, 'Changes in overall ventricular myocardial architecture in the setting of a porcine animal model of right ventricular dilation', Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, bind 19, nr. 1, s. 93. https://doi.org/10.1186/s12968-017-0404-0
Mikkelsen, EFR, Mariager, CØ, Nørlinger, T, Qi, H, Schulte, RF, Jakobsen, S, Frøkiær, J, Pedersen, M, Stødkilde-Jørgensen, H & Laustsen, C 2017, 'Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping', Scientific Reports, bind 7, nr. 1, s. 16002. https://doi.org/10.1038/s41598-017-15929-x
Wigh Lipsø, K, Hansen, ESS, Tougaard, RS, Laustsen, C & Ardenkjaer-Larsen, JH 2017, 'Renal MR angiography and perfusion in the pig using hyperpolarized water', Magnetic Resonance in Medicine, s. 1131-1135. https://doi.org/10.1002/mrm.26478
Østergaard Mariager, C, Nielsen, PM, Qi, H, Schroeder, M, Bertelsen, LB & Laustsen, C 2017, 'Can hyperpolarized 13C-Urea be used to assess glomerular filtration rate? a retrospective study', Tomography - A Journal for Imaging Research, bind 3, nr. 3.
Lauritzen, MH, Magnusson, P, Laustsen, C, Butt, SA, Ardenkjaer-Larsen, JH, Veje Søgaard, L, Paulson, OB & Åkeson, P 2017, 'Imaging regional metabolic changes in the ischemic rat heart in vivo using hyperpolarized(1-13C)Pyruvate', Tomography - A Journal for Imaging Research, bind 3, nr. 3, 3.
Xu, Y, Ringgaard, S, Mariager, CØ, Bertelsen, LB, Schroeder, M, Qi, H, Laustsen, C & Stødkilde-Jørgensen, H 2017, 'Hyperpolarized C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke', Tomography - A Journal for Imaging Research, bind 3, nr. 2, s. 67-73. https://doi.org/10.18383/j.tom.2017.00106
Mellbye, FB, Jeppesen, PB, Shokouh, P, Laustsen, C, Hermansen, K & Gregersen, S 2017, 'Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice', Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.7b00395
Mikkelsen, E, Lauridsen, H, Nielsen, PM, Qi, H, Nørlinger, T, Andersen, MD, Uldbjerg, N, Laustsen, C, Sandager, P & Pedersen, M 2017, 'The chinchilla as a novel animal model of pregnancy', Royal Society Open Science, bind 4, nr. 4, s. 161098. https://doi.org/10.1098/rsos.161098
Nørlinger, TS, Nielsen, PM, Qi, H, Mikkelsen, E, Hansen, K, Schmidt, NH, Pedersen, M, Agger, P, Palm, F & Laustsen, C 2017, 'Hyperbaric oxygen therapy reduces renal lactate production', Physiological Reports, bind 5, nr. 6. https://doi.org/10.14814/phy2.13217
Sanchez, JD, Søvsø Szocska Hansen, E, Laustsen, C, Zhurbenko, V & Ardenkjaer-Larsen, JH 2017, 'Low-Noise Active Decoupling Circuit and its Application to 13C Cryogenic RF Coils at 3T', Tomography - A Journal for Imaging Research, bind 3, nr. 1, s. 60-66. https://doi.org/10.18383/j.tom.2016.00280
Schroeder, M & Laustsen, C 2017, 'Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for cardiac and renal function assessement', Bioscience Reports. https://doi.org/10.1042/BSR20160186
Nielsen, PM, Eldirdiri, A, Bertelsen, LB, Jørgensen, HS, Ardenkjaer-Larsen, JH & Laustsen, C 2017, 'Fumarase activity: an in vivo and in vitro biomarker for acute kidney injury', Scientific Reports, bind 7, s. 40812. https://doi.org/10.1038/srep40812
Laustsen, C, Nielsen, PM, Nørlinger, TS, Qi, H, Pedersen, UK, Bertelsen, LB, Østergaard, JA, Flyvbjerg, A, Ardenkjær-Larsen, JH, Palm, F & Stødkilde-Jørgensen, H 2017, 'Antioxidant treatment attenuates lactate production in diabetic nephropathy', American Journal of Physiology: Renal Physiology, bind 312, nr. 1, s. F192-F199. https://doi.org/10.1152/ajprenal.00148.2016
Hansen, ESS, Tougaard, RS, Nørlinger, TS, Mikkelsen, E, Nielsen, PM, Bertelsen, LB, Bøtker, HE, Jørgensen, HS & Laustsen, C 2017, 'Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1-(13) C]pyruvate study', NMR in Biomedicine, bind 30, nr. 6. https://doi.org/10.1002/nbm.3702
Iversen, AB, Busk, M, Bertelsen, LB, Laustsen, C, Munk, OL, Nielsen, T, Wittenborn, TR, Bussink, J, Lok, J, Stødkilde-Jørgensen, H & Horsman, MR 2017, 'The potential of hyperpolarized (13)C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents', Acta oncologica (Stockholm, Sweden), bind 56, s. 1-8. https://doi.org/10.1080/0284186X.2017.1351622
Kierulf-Lassen, C, Nielsen, PM, Qi, H, Damgaard, M, Laustsen, C, Pedersen, M, Krag, S, Birn, H, Nørregaard, R & Jespersen, B 2017, 'Unilateral nephrectomy diminishes ischemic acute kidney injury through enhanced perfusion and reduced pro-inflammatory and pro-fibrotic responses', P L o S One, bind 12, nr. 12, s. e0190009. https://doi.org/10.1371/journal.pone.0190009
Laustsen, C 2016, 'Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?', Diabetes, bind 65, nr. 12, s. 3529-3531. https://doi.org/10.2337/dbi16-0055
Nielsen, PM, Szocska Hansen, ES, Nørlinger, TS, Nørregaard, R, Bonde Bertelsen, L, Stødkilde Jørgensen, H & Laustsen, C 2016, 'Renal ischemia and reperfusion assessment with three-dimensional hyperpolarized (13) C,(15) N2-urea', Magnetic Resonance in Medicine, bind 76, nr. 5, s. 1524-1530. https://doi.org/10.1002/mrm.26377
Nielsen, N, Laustsen, C & Bertelsen, LB 2016, '(13)C dynamic nuclear polarization for measuring metabolic flux in endothelial progenitor cells', Experimental Cell Research. https://doi.org/10.1016/j.yexcr.2016.10.002
Hansen, ESS, Stewart, NJ, Wild, JM, Stødkilde-Jørgensen, H & Laustsen, C 2016, 'Hyperpolarized (13) C,(15) N2 -Urea MRI for assessment of the urea gradient in the porcine kidney', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.26483
Nielsen, PM, Laustsen, C, Bertelsen, LB, Qi, H, Mikkelsen, E, Kristensen, MLV, Nørregaard, R & Stødkilde-Jørgensen, H 2016, 'In situ lactate dehydrogenase activity - a novel renal cortical imaging biomarker of tubular injury?', American Journal of Physiology: Renal Physiology, s. ajprenal.00561.2015. https://doi.org/10.1152/ajprenal.00561.2015
Koellisch, U, Laustsen, C, Nørlinger, TS, Østergaard, JA, Flyvbjerg, A, Gringeri, CV, Menzel, MI, Schulte, RF, Haase, A & Stødkilde-Jørgensen, H 2016, 'Current state-of-the-art hyperpolarized 13C-acetate-to-acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes', Physiological Reports, bind 4, nr. 17. https://doi.org/10.14814/phy2.12975
Juul, T, Palm, F, Nielsen, PM, Bertelsen, LB & Laustsen, C 2016, 'Ex vivo hyperpolarized MR spectroscopy on isolated renal tubular cells: A novel technique for cell energy phenotyping', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.26379
Hansen, ESS, Kim, S, Miller, JJ, Geferath, M, Morrell, G & Laustsen, C 2016, 'Fast Padé Transform Accelerated CSI for Hyperpolarized MRS', Tomography - A Journal for Imaging Research, bind 2, nr. 2, s. 117-124. https://doi.org/10.18383/j.tom.2016.00154
Bertelsen, LB, Nielsen, PM, Qi, H, Nørlinger, TS, Zhang, X, Stødkilde-Jørgensen, H & Laustsen, C 2016, 'Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized (13) C,(15) N-Urea', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.26256
Qi, H, Nørlinger, TS, Nielsen, PM, Bertelsen, LB, Mikkelsen, E, Xu, Y, Stødkilde Jørgensen, H & Laustsen, C 2016, 'Early diabetic kidney maintains the corticomedullary urea and sodium gradient', Physiological Reports, bind 4, nr. 5. https://doi.org/10.14814/phy2.12714
Bertelsen, LB, Nielsen, PM, Qi, H, Nørlinger, T, Zhang, X, Stødkilde-Jørgensen, H & Laustsen, C 2016, 'Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C,15N-urea', Magnetic Resonance in Medicine.
Agger, P, Lakshminrusimha, S, Laustsen, C, Gugino, S, Frandsen, J, Smerup, MH, Anderson, RH, Hjortdal, V & Steinhorn, RH 2015, 'The Myocardial Architecture changes in Persistent Pulmonary Hypertension of the Newborn in an Ovine Animal Model', Pediatric Research. https://doi.org/10.1038/pr.2015.263
Laustsen, C, Nørlinger, T, Christoffer Hansen, D, Qi, H, Mose Nielsen, P, Bonde Bertelsen, L, Henrik Ardenkjaer-Larsen, J & Stødkilde Jørgensen, H 2015, 'Hyperpolarized (13) C urea relaxation mechanism reveals renal changes in diabetic nephropathy', Magnetic Resonance in Medicine, bind 75, nr. 2, s. 515-518. https://doi.org/10.1002/mrm.26036
Iversen, AB, Ringgaard, S, Laustsen, C, Stødkilde-Jørgensen, H, Bentzen, L, Busk, M & Horsman, MR 2015, 'Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia', Acta Oncologica, s. 1393-1398. https://doi.org/10.3109/0284186X.2015.1070964
Laustsen, C, Søvsø Szocska Hansen, E, Pedersen, U, Bertelsen, LB, Ringgaard, S & Stødkilde-Jørgensen, H 2015, 'Acute porcine renal metabolic effect of endogastric soft drink administration assessed with hyperpolarized [1-13c]pyruvate', Magnetic Resonance in Medicine, bind 74/2, s. 558-563. https://doi.org/10.1002/mrm.25692
Koellisch, U, Laustsen, C, Nørlinger, TS, Østergaard, JA, Flyvbjerg, A, Gringeri, CV, Menzel, MI, Schulte, RF, Haase, A & Stødkilde-Jørgensen, H 2015, 'Investigation of metabolic changes in STZ-induced diabetic rats with hyperpolarized [1-13C]acetate', Physiological Reports, bind 3, nr. 8. https://doi.org/10.14814/phy2.12474
Lauritsen, SH, Bertelsen, LB, Daugård, P, Laustsen, C, Nielsen, N, Nygaard, JV & Stødkilde-Jørgensen, H 2015, 'Bioreactor for quantification of cell metabolism by MR-hyperpolarization', Biomedical Physics & Engineering Express, bind 1, nr. 4. https://doi.org/10.1088/2057-1976/1/4/047003
Qi, H, Zhang, X, Xu, Y, Wen, J, Xu, Y, Cheng, J, Chen, AP, Bertelsen, LB, Ringgaard, S, Laustsen, C & Stødkilde-Jørgensen, H 2015, 'Principle and application of hyperpolarized magnetic resonance spectroscopy', Chinese Journal of Magnetic Resonance Imaging , s. 881-887.
Laustsen, C, Lipsø, K, Ostergaard, JA, Nørregaard, R, Flyvbjerg, A, Pedersen, M, Palm, F & Ardenkjær-Larsen, J-H 2014, 'Insufficient insulin administration to diabetic rats increases substrate utilization and maintains lactate production in the kidney', Physiological Reports, bind 2, nr. 12, 2, s. 1-8. https://doi.org/10.14814/phy2.12233
Laustsen, C, Greferath, M, Ringgaard, S, Nielsen, NC & Ardenkjaer-Larsen, JH 2014, 'A new RF tagging pulse based on the Frank poly-phase perfect sequence', Journal of Magnetic Resonance, bind 247, s. 50-53. https://doi.org/10.1016/j.jmr.2014.08.011
Laustsen, C, Ardenkjaer-Larsen, JH, Pedersen, M, Ringgaard, S & Stødkilde-Jørgensen, H 2014, 'Hyperpolariseret magnetisk resonans kan in vivo kvantificere cellulær metabolisme', Ugeskrift for Laeger, bind 176, nr. 32, 176/32, s. 1486-1489.
Ardenkjaer-Larsen, JH, Laustsen, C, Bowen, S & Rizi, R 2014, 'Hyperpolarized H2 O MR angiography', Magnetic Resonance in Medicine, bind 71, nr. 1, s. 50-56. https://doi.org/10.1002/mrm.25033
Schmidt, R, Laustsen, C, Dumez, J-N, Kettunen, MI, Serrao, EM, Marco-Rius, I, Brindle, KM, Ardenkjaer-Larsen, JH & Frydman, L 2014, 'In vivo single-shot (13)C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding', Journal of Magnetic Resonance, bind 240C, s. 8-15. https://doi.org/10.1016/j.jmr.2013.12.013
Laustsen, C, Lycke, S, Palm, F, Østergaard, JA, Bibby, BM, Nørregaard, R, Flyvbjerg, A, Pedersen, M & Ardenkjaer-Larsen, JH 2014, 'High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging', Kidney International, bind 86, s. 67-74. https://doi.org/10.1038/ki.2013.504
Laustsen, C, Bowen, S, Sloth Vinding, M, Nielsen, NC & Ardenkjær-Larsen, JH 2014, 'Storage of magnetization as singlet order by optimal control designed pulses', Magnetic Resonance in Medicine, bind 71, nr. 3, s. 921–926. https://doi.org/10.1002/mrm.24733
Lauritzen, MH, Laustsen, C, Butt, SA, Magnusson, SP, Søgaard, LV-C, Ardenkjaer-Larsen, JH & Akeson, P 2013, 'Enhancing the [(13) C]bicarbonate signal in cardiac hyperpolarized [1-(13) C]pyruvate MRS studies by infusion of glucose, insulin and potassium', NMR in Biomedicine, s. 1496-1500. https://doi.org/10.1002/nbm.2982
Pileio, G, Bowen, S, Laustsen, C, Tayler, MCD, Hill-Cousins, JT, Brown, LJ, Brown, RCD, Ardenkjær-Larsen, JH & Levitt, MH 2013, 'Recycling and Imaging of Nuclear Singlet Hyperpolarization', Journal of the American Chemical Society, s. 5084–5088. https://doi.org/10.1021/ja312333v
Laustsen, C, Østergaard, J, Lauritzen, MH, Nørregaard, R, Bowen, S, Søgaard, LV-C, Flyvbjerg, A, Pedersen, M & Ardenkjaer-Larsen, JH 2013, 'Assessment of early diabetic renal changes with hyperpolarised [1-(13) C]pyruvate', Diabetes - Metabolism: Research and Reviews (Online), s. 125-129. https://doi.org/10.1002/dmrr.2370
Iversen, NK, Frische, S, Thomsen, K, Laustsen, C, Pedersen, M, Hansen, PBL, Bie, P, Fresnais, J, Berret, J-F, Baatrup, E & Wang, T 2013, 'Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice', Toxicology and Applied Pharmacology, bind 266, nr. 2, s. 276-88. https://doi.org/10.1016/j.taap.2012.10.014
Vinding, MS, Laustsen, C, Maximov, I, Søgaard, LV, Ardenkjær-Larsen, JH & Nielsen, NC 2013, 'Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS', Journal of Magnetic Resonance, bind 227, s. 57-61. https://doi.org/10.1016/j.jmr.2012.12.002
Laustsen, C, Pileio, G, Tayler, MCD, Brown, LJ, Brown, RCD, Levitt, MH & Ardenkjær-Larsen, JH 2012, 'Hyperpolarized Singlet NMR on a Small Animal Imaging System', Magnetic Resonance in Medicine, bind 68, s. 1262-1265.
Butt, SA, Søgaard, LV-C, Magnusson, SP, Lauritzen, MH, Laustsen, C, Akeson, P & Ardenkjær-Larsen, JH 2012, 'Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C Magnetic Resonance Spectroscopic Imaging', Journal of Cerebral Blood Flow and Metabolism, bind 32. https://doi.org/10.1038/jcbfm.2012.34
Pedersen, M, Laustsen, C, Perot, V, Basseau, F, Moonen, C & Grenier, N 2010, 'Renal hemodynamics and oxygenation in transient renal artery occluded rats evaluated with iron-oxide particles and oxygenation-sensitive imaging', Zeitschrift fuer Medizinische Physik, bind 20, nr. 2, s. 134-142. https://doi.org/10.1016/j.zemedi.2010.02.002
Rasmussen, AS, Lauridsen, H, Laustsen, C, Jensen, B, Fjord, S, Uhrenholt, L, Boel, LWT, Uldbjerg, N, Wang, T & Pedersen, M 2010, 'High-resolution ex vivo magnetic resonance angiography: a feasibility study on biological and medical tissues', B M C Physiology, bind 10, nr. 3. https://doi.org/10.1186/1472-6793-10-3
Laustsen, C, Ringgaard, S, Pedersen, M & Nielsen, NC 2010, 'Quadrupolar-coupling-specific binomial pulse sequences for in vivo(23)Na NMR and MRI', Journal of Magnetic Resonance, bind 206, s. 139-146. https://doi.org/10.1016/j.jmr.2010.06.017

Abstracts

NON-INVASIVE ASSESSMENT OF THE FIBROGENIC RESPONSE FOLLOWING ISCHEMIA/REPERFUSION INJURY IN RODENTS

Rasmussen, D., Nielsen, P. M., Mariager, C., Laustsen, C., Karsdal, M., Genovese, F., Molmer, M. & Norregaard, R., maj 2018, s. 102-103. 2 s.

3D Reconstruction and Fiber Quantification in the Pig Lower Esophageal Sphincter region In vitro Diffusion Tensor Imaging

Liao, D., Gregersen, H., Agger, P., Laustsen, C., Ringgaard, S., Stødkilde-Jørgensen, H. & Zhao, J., nov. 2017, s. 57. 1 s.

REAL-TIME, IN VIVO MEASUREMENTS OF PYRUVATE METABOLISM IN THE LIVER AND KIDNEYS OF BRAIN-DEAD RATS WITH HYPERPOLARIZED [1-13C]-PYRUVATE MAGNETIC RESONANCE IMAGING

Van Erp, A., Qi, H., Ottens, P., Norregaard, R., Pedersen, M., Leuvenink, H., Laustsen, C. & Jespersen, B., sep. 2017, s. 573-573. 1 s.

Hyperpolarized [1-13C]-MRI in an ectothermic repile

Hansen, K., Nielsen, P. M., Søvsø Szocska Hansen, E., Williams, C., Joyce, W., Pedersen, M., Wang, T. & Laustsen, C., 27 apr. 2017.

Changes in overall ventricular myocardial architecture in the setting of a porcine animal model of right ventricular dilation

Agger, P., Ilkjær, C., Laustsen, C., Smerup, M. H., Frandsen, J., Ringgaard, S., Pedersen, M., Partridge, J. B., Anderson, R. H. & Hjortdal, V. E., 2017.

Dynamic remodelling of the right ventricular myocardium through the cardiac cycle

Christensen, C. O., Laustsen, C., Hjortdal, V. E. & Agger, P., 2017.

Myocardial metabolism in heart failure induced by right ventricular volume overload

Bøgh, N., Petersen, M. F., Christensen, C. O., Hjortdal, V. E., Søvsø Szocska Hansen, E., Laustsen, C. & Agger, P., 2017.

The architecture of the right ventricular myocardium changes through the cardiac cycle

Christensen, C. O., Laustsen, C., Hjortdal, V. E. & Agger, P., 2017.

In Situ lactate dehydrogenase activiy-a novel renal cortical imaging biomarker of tubular injury?

Nielsen, P. M., Laustsen, C., Bertelsen, L. B., Qi, H., Mikkelsen, E., Kristensen, M-L. V., Nørregaard, R. & Stødkilde-Jørgensen, H., 3 apr. 2016.

Oxygen metabolic competition in the lactic acidotic diabetic kidney: A point of no return?

Laustsen, C., Lipsø, H. K. W., Østergaard, J. A., Nielsen, P. M., Flyvbjerg, A., Pedersen, M., Palm, F. & Ardenkjær-Larsen, J. H., 3 apr. 2016.

Diffusion tensor magnetic resonance imaging for evaluation of changes of myocardial architecture through the cardiac cycle in the right ventricle

Christensen, C. O., Agger, P., Laustsen, C. & Hjortdal, V. E., 2016.

Renal Urea Transport Alterations with Prolonged Hyperglycaemia

Bertelsen, L. B., Nielsen, P. M., Qi, H., Nørlinger, T., Zhang, X., Stødkilde-Jørgensen, H. & Laustsen, C., 2016.

A Gadgetron based hyperpolarised 13C analysis module for multi-vendor clinical translation

Hansen, D. C., F. Schulte, R., Sangild, T., Ringgaard, S., Stødkilde-Jørgensen, H. & Laustsen, C., 2015.

Investigation of Metabolic Changes in STZ Induced Diabetic Rats with Hyperpolarized [1-13C]Acetate

Koellisch, U., Laustsen, C., Nørlinger, T., Østergaard, J. A., Flyvbjerg, A., V. Gringeri, C., I. Menzel, M., F. Schulte, R., Haase, A. & Stødkilde-Jørgensen, H., 2015, I : Proc ISMRM. 1890.

Sa1112 Three-Dimensional Myoarchitecture of Porcine Gastro-Esophageal Junction With Diffusion Tensor Imaging

Gregersen, H., Liao, D., Zhao, J., Ringgaard, S., Agger, P., Laustsen, C. & Stødkilde-Jørgensen, H., 2015, I : Gastroenterology. 148

The Myocardial Architecture Changes due to Persistent Pulmonary Hypertension of the Newborn in an Ovine Animal Model

Agger, P., Lakshminrusimha, S., Laustsen, C., Gugino, S., Frandsen, J., Smerup, M. H., Anderson, R. H., Hjortdal, V. E. & Steinhorn, R. H., 2015, I : Journal of Pediatric and Neonatal Individualized Medicine. 79, 4, s. 565-74 10 s.

Three-dimensional Myoarchitecture of Porcine Esophago-Gastric Junction with Diffusion Tensor Imaging. Selected for poster presentation.

Gregersen, H., Liao, D., Zhao, J., Ringgaard, S., Agger, P., Laustsen, C. & Stødkilde-Jørgensen, H., 2015.

Hyperpolarized 13C MRS reveals oxygen sensitive pseudo hypxia in the diabetic kidney

Laustsen, C., Lipsoe, K., Palm, F., Østergaard, J. A., Nørregaard, R., Flyvbjerg, A., Pedersen, M. & Ardenkjaer-Larsen, J. H., 21 mar. 2014.

Myocardial remodelling due to right ventricular dilatation in congenital heart disease

Agger, P., Ilkjær, C., Laustsen, C., Smerup, M. H., Nielsen-Kudsk, J. E., Pedersen, M. & Hjortdal, V. E., 2014.

A Ultra Fast 79Br B1 Calibration Method for 13C Coils for Hyperpolarized Studies

Laustsen, C. & Ardenkjær-Larsen, J. H., 6 okt. 2011, I : ESMRMB.

Longtime storage of hyperpolarization via singlet states in high field

Pileio, G., Laustsen, C., Brown, L. J., Bocan, J., Tayler, M. C. D., Brown, R. C. D., Ardenkjaer-Larsen, J. H. & Levitt, M. H., 27 jul. 2011, I : EUROMAR.

Ex vivo ischemic kidney damage 23Na relaxometry

Laustsen, C., Ringgaard, S., Damkjær, M. & Pedersen, M., 7 maj 2011, I : Proc ISMRM.

Hyperpolarized water for interventional angiography

Ardenkjær-Larsen, J. H., Laustsen, C., Pullinger, B., Kadlecek, S., Emami, K. & Rizi, R., 7 maj 2011, I : Proc ISMRM.

Optimal control developed 23Na NMR pulses for selective detection of a specific broadband quadrupolar coupling range

Laustsen, C., 2010.

Development of a clinical 23Na quantification NMR/MRI technique

Laustsen, C., 2009.

MRI zoo

Laustsen, C., 2009.

Development of a clinical 23Na quantification NMR/MRI technique

Laustsen, C., 27 sep. 2008.

Foredrag

13C & 23Na

Christoffer Laustsen (Foredragsholder)
12 jul. 2010

34th Danish NMR meeting

Christoffer Laustsen (Deltager)
21 jan. 201322 jan. 2013

Acquisition Strategies for Hyperpolarized Spin Systems

Christoffer Laustsen (Deltager)
25 aug. 201327 aug. 2013

Assesment of diabetic nephropathy with Hyperpolarised [1-13C]Pyruvat

Christoffer Laustsen (Foredragsholder)
20 jan. 2012

Assessment of early diabetic renal changes with hyperpolarised [1-13C]pyruvate

Christoffer Laustsen (Foredragsholder)
22 nov. 2012

Binomial sequences for S=3/2 nuclei for selective detection of intracellular sodium

Christoffer Laustsen (Foredragsholder)
25 jan. 2010

COST PARENCHIMA WP1 leader update

Christoffer Laustsen (Foredragsholder)
4 okt. 2018

COST Spin Hyperpolarisation meeting

Christoffer Laustsen (Deltager)
29 jun. 20121 jul. 2012

COST summer school 2012 on Spin-Hyperpolarization

Christoffer Laustsen (Deltager)
29 okt. 20122 nov. 2012

Cardiac metabolism assessed with Hyperpolarized MR

Christoffer Laustsen (Foredragsholder)
27 nov. 2012

Comparison of perfusion markers in the ex-vivo perfused porcine kidney: hyperpolarized [1-13C]pyruvate versus gold standard 1H DCE MRI

Christian Østergaard Mariager (Oplægsholder), Esben Søvsø Szocska Hansen (Andet), Sabrina Kahina Bech (Andet), Anders Munk (Andet), Mads Dam Lyhne (Andet), Karsten Søberg (Andet), Peter Fast Nielsen (Andet), Steffen Ringgaard (Andet), Christoffer Laustsen (Andet)
2019

Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, København (Ekstern organisation)

Christoffer Laustsen (Medlem)
13 aug. 2019

Dynamic Nuclear Polarization (DNP) from solid to metabolic activity in seconds

Christoffer Laustsen (Foredragsholder)
26 maj 2010

EPIC programming

Christoffer Laustsen (Deltager)
16 sep. 201319 sep. 2013

European Network for Hyperpolarization Physics and Methodology in NMR and MRI (Ekstern organisation)

Christoffer Laustsen (Medlem)
2012 → …

European Network for Hyperpolarization Physics and Methodology in NMR and MRI (Ekstern organisation)

Christoffer Laustsen (Medlem)
2012 → …

Fast Pade Transform accelerated CSI for hyperpolarized MRS

Christoffer Laustsen (Foredragsholder)
27 jun. 2014

Fifth International Workshop on Metabolic Imaging

Christoffer Laustsen (Deltager)
18 okt. 201820 okt. 2018

Fractional perfusion: A simple semi-parametric measure for clinical translation of hyperpolarized 13C MR?

Christoffer Laustsen (Foredragsholder), Per Mose Nielsen (Foredragsholder), Steffen Ringgaard (Foredragsholder)
20 okt. 2017

Frank NMR and MRI

Christoffer Laustsen (Foredragsholder)
5 feb. 201112 feb. 2011

Hyperpolariseret MR til human anvendelse

Christoffer Laustsen (Foredragsholder)
1 jun. 2017

Hyperpolarization - Clinical Potential & Relevance

Christoffer Laustsen (Foredragsholder)
26 apr. 2017

Hyperpolarized 13C MRS reveals hypoxia accelerates pseudo hypoxia in the diabetic kidney

Christoffer Laustsen (Foredragsholder)
28 apr. 2014

Hyperpolarized 13C development for diabetes

Christoffer Laustsen (Foredragsholder)
13 nov. 2013

Hyperpolarized Functional and Metabolic Kidney Imaging

Christoffer Laustsen (Foredragsholder)
20 okt. 2018

Hyperpolarized Media MR committee member (Ekstern organisation)

Christoffer Laustsen (Sekretær)
20162019

Hyperpolarized Metabolic and Functional Cardio and Renal MR Imaging

Christoffer Laustsen (Foredragsholder)
2 feb. 2017

Hyperpolarized long-lived storage: A potential solution to MRI guided therapeutics and monitoring

Christoffer Laustsen (Foredragsholder)
16 okt. 2012

Hyperpolarized magnetic resonance Imaging – potential and pitfalls

Christoffer Laustsen (Foredragsholder)
18 sep. 2019

Hyperpolarized magnetic resonance Imaging – potential for placenta imaging ?

Christoffer Laustsen (Foredragsholder)
19 sep. 2019

Hyperpolarized singlet state storage: Extending the life-time of DNP

Christoffer Laustsen (Foredragsholder)
22 jan. 2013

Imaging oxygen metabolism: new findings in both animal and human studies

Christoffer Laustsen (Foredragsholder)
24 maj 2016

Imaging renal functional and metabolic alterations with hyperpolarized MR

Christoffer Laustsen (Foredragsholder)
9 okt. 2017

In vivo and ex vivo [1-13C]pyruvate examinations

Christoffer Laustsen (Foredragsholder)
14 mar. 201915 mar. 2019

Induction heating of gold particles in an MRI-system

Christoffer Laustsen (Foredragsholder)
20 jun. 2007

International Society for Magnetic Resonance in Medicine (Ekstern organisation)

Christoffer Laustsen (Medlem)
2010 → …

International Society for Magnetic Resonance in Medicine Nordic Chapter (Ekstern organisation)

Christoffer Laustsen (Medlem)
2012 → …

Introduction to Hyperpolarised MR & Metabolism

Christoffer Laustsen (Foredragsholder)
11 maj 2016

LEADER COURSE

Christoffer Laustsen (Deltager)
6 aug. 201217 aug. 2012

Leading the Virtual Company – PasteurProgram 2015

Christoffer Laustsen (Deltager)
2015 → …

METABOLIC IMAGING WITH HYPERPOLARIZED MR – POTENTIAL FOR DRUG DEVELOPMENT

Christoffer Laustsen (Foredragsholder)
14 mar. 2018

Measurements of metabolism using hyperpolarized MRI

Christoffer Laustsen (Foredragsholder)
6 mar. 2013

Metabolic imaging with hyperpolarized MR

Christoffer Laustsen (Foredragsholder)
18 jan. 2018

Molecular imaging: Hyperpolarisation, magnetization transfer, CEST

Christoffer Laustsen (Foredragsholder)
11 okt. 2017

New non-invasive imaging techniques for animal use

Christoffer Laustsen (Foredragsholder)
21 sep. 2012

Opfindelse og anvendelse af Hyperpolarisatoren

Christoffer Laustsen (Foredragsholder)
13 sep. 2014

Optimal Control Singlet State Storage of hyperpolarized compounds

Christoffer Laustsen (Foredragsholder)
25 jul. 2012

Oxygen metabolic competition in the diabetic kidney: A new metabolic phenotype in animal models of diabetes?

Christoffer Laustsen (Foredragsholder)
19 aug. 2017

PhD Examination – Charlotte Daniels

Christoffer Laustsen (Deltager)
9 nov. 2017

Pre-clinical DNP

Christoffer Laustsen (Foredragsholder)
5 okt. 20117 okt. 2011

Pre-clinical SPINLAB’ing

Christoffer Laustsen (Foredragsholder)
26 apr. 2017

Pre-clinical considerations - for clinical translation

Christoffer Laustsen (Foredragsholder)
16 mar. 2018

Preclinical Hyperpolarizared MRI

Christoffer Laustsen (Foredragsholder)
4 dec. 2017

RENAL METABOLISM DURING ALTERED OXYGEN AVAILABILITY, ASSESSED WITH HYPERPOLARIZED [1-13C]PYRUVATE

Christoffer Laustsen (Foredragsholder)
28 aug. 2013

Renal functional and metabolic imaging using hyperpolarized MR 

Christoffer Laustsen (Foredragsholder)
3 dec. 2017

ScanBalt Forum 2014

Christoffer Laustsen (Taler)
9 okt. 2014

Sensitivity Challenges in Contemporary Biomolecular Magnetic Resonance

Christoffer Laustsen (Deltager)
27 feb. 201328 feb. 2013

Swine renal and hepatic metabolism assessed with hyperpolarized MR

Christoffer Laustsen (Foredragsholder)
9 feb. 201510 feb. 2015

The Aarhus vision for Hyperpolarized 13C MRI

Christoffer Laustsen (Foredragsholder)
13 aug. 2019

Using Hyperpolarized 13C Labeled Urea as a Possible Endogenous Marker for Identifying Renal Impairment

Christoffer Laustsen (Foredragsholder)
26 feb. 2016

Uddannelse

2011Laboratory Animal science certified
2009Aarhus University — Mcs Nanoscience
2007Aarhus University — Bcs Nanoscience