Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » Christian Skødt Antoniussen » Publikationer » The association between body fatness and mortality among ...

Om AU

Christian Skødt Antoniussen

The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Catalina Bonet, Bellvitge Biomedical Research Institute - IDIBELL
    • ,
  • Marta Crous-Bou, Bellvitge Biomedical Research Institute - IDIBELL
    • ,
  • Konstantinos K Tsilidis, Imperial College London
    • ,
  • Marc J Gunter, Genetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France. johanssonm@iarc.fr.
    • ,
  • Rudolf Kaaks, RNA Biology and Cancer German Cancer Research Center (DKFZ)
    • ,
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke
    • ,
  • Renée T Fortner, RNA Biology and Cancer German Cancer Research Center (DKFZ)
    • ,
  • Christian S Antoniussen
  • Christina C Dahm
  • Lene Mellemkjær, Kræftens Bekæmpelse
    • ,
  • Anne Tjønneland, Kræftens Bekæmpelse
    • ,
  • Pilar Amiano, Ministry of Health of the Basque Government
    • ,
  • Eva Ardanaz, Biodonostia Research Institute CIBER Epidemiology and Public Health CIBERESP
    • ,
  • Sandra M Colorado-Yohar, Biodonostia Research Institute CIBER Epidemiology and Public Health CIBERESP
    • ,
  • Miguel Rodriguez-Barranco, Biodonostia Research Institute CIBER Epidemiology and Public Health CIBERESP
    • ,
  • Sandar Tin Tin, University of Oxford
    • ,
  • Claudia Agnoli, Epidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    • ,
  • Giovanna Masala, Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research
    • ,
  • Salvatore Panico, Roma Tre University
    • ,
  • Carlotta Sacerdote, University of Turin
    • ,
  • Anne M May, University Medical Centre Utrecht
    • ,
  • Kristin Benjaminsen Borch, UiT The Arctic University of Norway
    • ,
  • Charlotta Rylander, UiT The Arctic University of Norway
    • ,
  • Guri Skeie, UiT The Arctic University of Norway
    • ,
  • Sofia Christakoudi, Imperial College London
    • ,
  • Dagfinn Aune, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
    • ,
  • Elisabete Weiderpass, Office of the Clinical Director , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.
    • ,
  • Laure Dossus, Nutrition and Metabolism Branch
    • ,
  • Elio Riboli, Imperial College London
    • ,
  • Antonio Agudo, Bellvitge Biomedical Research Institute - IDIBELL

Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study included 13,624 BC survivors from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with a mean follow-up of 8.6 years after diagnosis. Anthropometric data were obtained at recruitment for all cases and at a second assessment during follow-up for a subsample. We measured general obesity using the body mass index (BMI), whereas waist circumference and A Body Shape Index were used as measures of abdominal obesity. The annual weight change was calculated for cases with two weight assessments. The association with overall mortality and BC-specific mortality were based on a multivariable Cox and Fine and Gray models, respectively. We performed Mendelian randomization (MR) analysis to investigate the potential causal association. Five-unit higher BMI prediagnosis was associated with a 10% (95% confidence interval: 5-15%) increase in overall mortality and 7% (0-15%) increase in dying from BC. Women with abdominal obesity demonstrated a 23% (11-37%) increase in overall mortality, independent of the association of BMI. Results related to weight change postdiagnosis suggested a U-shaped relationship with BC-specific mortality, with higher risk associated with losing weight or gaining > 2% of the weight annually. MR analyses were consistent with the identified associations. Our results support the detrimental association of excess body fatness on the survival of women with BC. Substantial weight changes postdiagnosis may be associated with poorer survival.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind38
Nummer5
Sider (fra-til)545-557
ISSN0393-2990
DOI
StatusUdgivet - maj 2023

Bibliografisk note

© 2023. The Author(s).

Se relationer på Aarhus Universitet Citationsformater

ID: 314648560