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Christian Skødt Antoniussen

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Carlota Castro-Espin, Catalan Institute of Oncology - ICO
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  • Catalina Bonet, Catalan Institute of Oncology - ICO
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  • Marta Crous-Bou, Catalan Institute of Oncology - ICO
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  • Verena Katzke, German Cancer Research Center
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  • Charlotte Le Cornet, German Institute of Human Nutrition Potsdam-Rehbruecke
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  • Franziska Jannasch, German Institute of Human Nutrition Potsdam-Rehbruecke
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  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke
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  • Anja Olsen, Kræftens Bekæmpelse, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
    • ,
  • Anne Tjønneland, Kræftens Bekæmpelse
    • ,
  • Christina C Dahm
  • Christian S Antoniussen
  • Maria Jose Sánchez, Escuela Andaluza de Salud Publica
    • ,
  • Pilar Amiano, CIBER - Center for Biomedical Research Network
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  • María Dolores Chirlaque, CIBER - Center for Biomedical Research Network
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  • Marcela Guevara, CIBER - Center for Biomedical Research Network
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  • Claudia Agnoli, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
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  • Rosario Tumino, Hyblean Association for Epidemiological Research (AIRE-ONLUS)
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  • Carlotta Sacerdote, University of Turin
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  • Maria Santucci De Magistris, University of Naples Federico II
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  • Malin Sund, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Stina Bodén, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Torill Enget Jensen, UiT The Arctic University of Norway
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  • Karina Standahl Olsen, UiT The Arctic University of Norway
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  • Guri Skeie, UiT The Arctic University of Norway
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  • Marc J Gunter, International Agency for Research on Cancer
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  • Sabina Rinaldi, Nutrition and Metabolism Branch
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  • Esther M Gonzalez-Gil, Nutrition and Metabolism Branch
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  • Elisabete Weiderpass, Nutrition and Metabolism Branch
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  • Sofia Christakoudi, Imperial College London
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  • Alicia K Heath, Imperial College London
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  • Laure Dossus, Nutrition and Metabolism Branch
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  • Antonio Agudo, Catalan Institute of Oncology - ICO

BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.

METHODS: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.

RESULTS: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.

CONCLUSIONS: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind128
Nummer7
Sider (fra-til)1301-1310
ISSN0007-0920
DOI
StatusUdgivet - mar. 2023

Bibliografisk note

© 2023. The Author(s).

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