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Christian Skødt Antoniussen

Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Edoardo Botteri, Cancer Registry of Norway
    • ,
  • Giulia Peveri, University of Milan
    • ,
  • Paula Berstad, Cancer Registry of Norway
    • ,
  • Vincenzo Bagnardi, University of Milan - Bicocca
    • ,
  • Sairah L F Chen, UiT The Arctic University of Norway
    • ,
  • Torkjel M Sandanger, UiT The Arctic University of Norway
    • ,
  • Geir Hoff, Cancer Registry of Norway, Telemark Hospital
    • ,
  • Christina C Dahm
  • Christian S Antoniussen
  • Anne Tjønneland, Kræftens Bekæmpelse
    • ,
  • Anne Kirstine Eriksen, Kræftens Bekæmpelse
    • ,
  • Guri Skeie, UiT The Arctic University of Norway
    • ,
  • Aurora Perez-Cornago, University of Oxford
    • ,
  • José María Huerta, Murcia Regional Health Council, CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
    • ,
  • Paula Jakszyn, Catalan Institute of Oncology - ICO
    • ,
  • Sophia Harlid, Umeå University
    • ,
  • Björn Sundström, Umeå University
    • ,
  • Aurelio Barricarte, CIBER de Epidemiología y Salud Pública (CIBERESP), Spain., Universidad Pública de Navarra
    • ,
  • Evelyn M Monninkhof, Utrecht University
    • ,
  • Jeroen W G Derksen, Utrecht University
    • ,
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam
    • ,
  • Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM)
    • ,
  • Maria-Jose Sánchez, CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
    • ,
  • Amanda J Cross, Imperial College London
    • ,
  • Konstantinos K Tsilidis, Imperial College London, University of Ioannina
    • ,
  • Maria Santucci De Magistris, University of Naples Federico II
    • ,
  • Rudolf Kaaks, German Cancer Research Center
    • ,
  • Verena Katzke, German Cancer Research Center
    • ,
  • Joseph A Rothwell, Universite Paris-Saclay
    • ,
  • Nasser Laouali, Universite Paris-Saclay
    • ,
  • Gianluca Severi, Universite Paris-Saclay, University of Florence
    • ,
  • Pilar Amiano, Ministry of Health of the Basque Government
    • ,
  • Paolo Contiero, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    • ,
  • Carlotta Sacerdote, University of Turin
    • ,
  • Marcel Goldberg, Population-based Epidemiologic Cohorts Unit
    • ,
  • Mathilde Touvier, Universite Paris 1 Pantheon-Sorbonne
    • ,
  • Heinz Freisling, World Health Organization
    • ,
  • Vivian Viallon, World Health Organization
    • ,
  • Elisabete Weiderpass, World Health Organization
    • ,
  • Elio Riboli, Imperial College London
    • ,
  • Mazda Jenab, World Health Organization
    • ,
  • Pietro Ferrari, World Health Organization

INTRODUCTION: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort.

METHODS: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI).

RESULTS: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile.

DISCUSSION: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.

OriginalsprogEngelsk
TidsskriftThe American Journal of Gastroenterology
Vol/bind118
Nummer4
Sider (fra-til)702-711
Antal sider10
ISSN0002-9270
DOI
StatusUdgivet - apr. 2023

Bibliografisk note

Copyright © 2022 by The American College of Gastroenterology.

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