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Christian Fyhn Reuss

Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death. / Reuss, Christian Fyhn; Hasselstrøm, Jørgen Bo; Linnet, Kristian; Jensen Christoffersen, Dorte; Leth, Peter Mygind; Boel, Lene Warner Thorup; Banner, Jytte.

I: Journal of Forensic Sciences, Bind 66, Nr. 1, 01.2021, s. 255-264.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Reuss, CF, Hasselstrøm, JB, Linnet, K, Jensen Christoffersen, D, Leth, PM, Boel, LWT & Banner, J 2021, 'Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death', Journal of Forensic Sciences, bind 66, nr. 1, s. 255-264. https://doi.org/10.1111/1556-4029.14586

APA

Reuss, C. F., Hasselstrøm, J. B., Linnet, K., Jensen Christoffersen, D., Leth, P. M., Boel, L. W. T., & Banner, J. (2021). Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death. Journal of Forensic Sciences, 66(1), 255-264. https://doi.org/10.1111/1556-4029.14586

CBE

Reuss CF, Hasselstrøm JB, Linnet K, Jensen Christoffersen D, Leth PM, Boel LWT, Banner J. 2021. Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death. Journal of Forensic Sciences. 66(1):255-264. https://doi.org/10.1111/1556-4029.14586

MLA

Vancouver

Author

Reuss, Christian Fyhn ; Hasselstrøm, Jørgen Bo ; Linnet, Kristian ; Jensen Christoffersen, Dorte ; Leth, Peter Mygind ; Boel, Lene Warner Thorup ; Banner, Jytte. / Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death. I: Journal of Forensic Sciences. 2021 ; Bind 66, Nr. 1. s. 255-264.

Bibtex

@article{6b6f5fab1fa1484abd594b87b1b16c14,
title = "Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death",
abstract = "Patients suffering from psychiatric disorders have an excess mortality and a shorter life span expectancy compared to the general population. Furthermore, they are treated with multiple drugs and are known to have an increased risk of drug abuse. In this study, we aimed at investigating the pharmaceutical drug and drug of abuse profiles of the deceased included in the Danish prospective autopsy-based forensic study on psychiatric patients, SURVIVE. Using the postmortem systematic toxicological analysis results, we identified 129 different consumed compounds in our population (n = 443). Polypharmacy (≥5 compounds) was detected in 39.5% of the deceased. Deceased with a psychiatric diagnosis or who died from a fatal intoxication had significantly more compounds at the time of their death compared to having either no psychiatric diagnosis or another cause of death, respectively. Evidence of drug abuse was present, as 29.8% of our total population had consumed either methadone or illicit drugs of abuse, excluding tetrahydrocannabinol. Of those deceased with a psychiatric diagnosis, 33.6% had either consumed methadone or illicit drugs of abuse, a greater number than those without a psychiatric diagnosis. Fatal intoxication was the most frequent cause of death (40.6%) with methadone as the major intoxicant. Here, we found that those without a psychiatric diagnosis had fewer fatal pharmaceutical drug intoxications compared to the psychiatric diagnosis groups. Our findings add further context to understanding the excess mortality of psychiatric patents, since there is an increased occurrence of fatal intoxication, polypharmacy, and drug abuse in this population.",
keywords = "drug abuse, forensic toxicology, intoxication, polypharmacy, psychiatric patients, psychotropic drugs",
author = "Reuss, {Christian Fyhn} and Hasselstr{\o}m, {J{\o}rgen Bo} and Kristian Linnet and {Jensen Christoffersen}, Dorte and Leth, {Peter Mygind} and Boel, {Lene Warner Thorup} and Jytte Banner",
year = "2021",
month = jan,
doi = "10.1111/1556-4029.14586",
language = "English",
volume = "66",
pages = "255--264",
journal = "Journal of Forensic Sciences",
issn = "0022-1198",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death

AU - Reuss, Christian Fyhn

AU - Hasselstrøm, Jørgen Bo

AU - Linnet, Kristian

AU - Jensen Christoffersen, Dorte

AU - Leth, Peter Mygind

AU - Boel, Lene Warner Thorup

AU - Banner, Jytte

PY - 2021/1

Y1 - 2021/1

N2 - Patients suffering from psychiatric disorders have an excess mortality and a shorter life span expectancy compared to the general population. Furthermore, they are treated with multiple drugs and are known to have an increased risk of drug abuse. In this study, we aimed at investigating the pharmaceutical drug and drug of abuse profiles of the deceased included in the Danish prospective autopsy-based forensic study on psychiatric patients, SURVIVE. Using the postmortem systematic toxicological analysis results, we identified 129 different consumed compounds in our population (n = 443). Polypharmacy (≥5 compounds) was detected in 39.5% of the deceased. Deceased with a psychiatric diagnosis or who died from a fatal intoxication had significantly more compounds at the time of their death compared to having either no psychiatric diagnosis or another cause of death, respectively. Evidence of drug abuse was present, as 29.8% of our total population had consumed either methadone or illicit drugs of abuse, excluding tetrahydrocannabinol. Of those deceased with a psychiatric diagnosis, 33.6% had either consumed methadone or illicit drugs of abuse, a greater number than those without a psychiatric diagnosis. Fatal intoxication was the most frequent cause of death (40.6%) with methadone as the major intoxicant. Here, we found that those without a psychiatric diagnosis had fewer fatal pharmaceutical drug intoxications compared to the psychiatric diagnosis groups. Our findings add further context to understanding the excess mortality of psychiatric patents, since there is an increased occurrence of fatal intoxication, polypharmacy, and drug abuse in this population.

AB - Patients suffering from psychiatric disorders have an excess mortality and a shorter life span expectancy compared to the general population. Furthermore, they are treated with multiple drugs and are known to have an increased risk of drug abuse. In this study, we aimed at investigating the pharmaceutical drug and drug of abuse profiles of the deceased included in the Danish prospective autopsy-based forensic study on psychiatric patients, SURVIVE. Using the postmortem systematic toxicological analysis results, we identified 129 different consumed compounds in our population (n = 443). Polypharmacy (≥5 compounds) was detected in 39.5% of the deceased. Deceased with a psychiatric diagnosis or who died from a fatal intoxication had significantly more compounds at the time of their death compared to having either no psychiatric diagnosis or another cause of death, respectively. Evidence of drug abuse was present, as 29.8% of our total population had consumed either methadone or illicit drugs of abuse, excluding tetrahydrocannabinol. Of those deceased with a psychiatric diagnosis, 33.6% had either consumed methadone or illicit drugs of abuse, a greater number than those without a psychiatric diagnosis. Fatal intoxication was the most frequent cause of death (40.6%) with methadone as the major intoxicant. Here, we found that those without a psychiatric diagnosis had fewer fatal pharmaceutical drug intoxications compared to the psychiatric diagnosis groups. Our findings add further context to understanding the excess mortality of psychiatric patents, since there is an increased occurrence of fatal intoxication, polypharmacy, and drug abuse in this population.

KW - drug abuse

KW - forensic toxicology

KW - intoxication

KW - polypharmacy

KW - psychiatric patients

KW - psychotropic drugs

U2 - 10.1111/1556-4029.14586

DO - 10.1111/1556-4029.14586

M3 - Journal article

C2 - 33017048

VL - 66

SP - 255

EP - 264

JO - Journal of Forensic Sciences

JF - Journal of Forensic Sciences

SN - 0022-1198

IS - 1

ER -