Aarhus Universitet

Christian Bjerggaard Vægter

Sortilin in microglia reactivity: Investigating the mechanism underlying the impairment of neuropathic pain in sortilin knockout mice

Publikation: KonferencebidragKonferenceabstrakt til konferenceForskning

Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.

Neuroinflammation is a major contributing factor in the development of neuropathic pain. It has been well accepted that activation of microglia is essential in the spinal neuroinflammatory process underlying development of neuropathic pain after peripheral nerve injury. Unpublished data from sortilin knockout mice shows that the lack of the neuronal receptor, Sortilin, decreases development of neuropathic pain after peripheral nerve injury. Because Sortilin influences the inflammatory response in macrophages, it may also affect the response in microglia and the spinal neuroinflammation. Therefore, the aim of this project is to understand how Sortilin influences the spinal microglial response following peripheral nerve injury.

We plan to investigate cultures of spinal microglia from wild type and Sortilin knockout mice by comparing the cytokine profiles in culture medium, gene expression and intracellular protein levels of cytokines. Understanding the response in microglia might contribute to the knowledge of neuroinflammatory diseases in general and hopefully prove Sortilin as a potential drug target in the development of future treatments for neuropathic pain.
OriginalsprogEngelsk
Udgivelsesår2 jul. 2016
StatusUdgivet - 2 jul. 2016
Begivenhed10th FENS Forum of Neuroscience - København, Danmark
Varighed: 2 jul. 20166 jul. 2016

Konference

Konference10th FENS Forum of Neuroscience
LandDanmark
ByKøbenhavn
Periode02/07/201606/07/2016

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