Institut for Biomedicin

Christian Aalkjær

Mechanism of the vasodilator action of pinacidil

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  • Institut for Fysiologi og Biofysik
  • Farmakologisk Institut
The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K+ permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K+ permeability. Lastly, the results suggest that the K+ channels involved are sensitive to glibenclamide.
OriginalsprogEngelsk
TidsskriftBlood vessels
Vol/bind27
Nummer2-5
Sider (fra-til)314-318
Antal sider5
ISSN0303-6847
StatusUdgivet - 1 jan. 1990

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