Institut for Biomedicin

Christian Aalkjær

Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels

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Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels. / Heagerty, A M; Bund, S J; Aalkjær, Christian.

I: Lancet, Bind 2, Nr. 8622, 26.11.1988, s. 1209-1212.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{78fe3775b91440238bafe6bffa4a824e,
title = "Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels",
abstract = "To examine whether effective drug treatment would reverse the morphological changes in resistance arterioles which characterise untreated essential hypertension, the vessels' media thickness and contractility were measured before and after long-term treatment. Nine patients underwent skin biopsy before and after a mean 13 months of antihypertensive treatment (range 4-24 months). Subcutaneous resistance arterioles were dissected and mounted in a myograph. Treatment did not affect the shift in sensitivity to noradrenaline in the presence of cocaine, sensitivity to exogenously administered calcium, and the rate of relaxation after withdrawal of vasoconstrictor stimuli. The media/lumen ratio fell significantly (p = 0.011) owing to a significant regression in media thickness (p = 0.0195), but this was not complete. Thus, effective antihypertensive treatment can reverse some of the structural change observed in the untreated state, although it apparently does not affect calcium sensitivity or relaxation rate; these features are thought to be consequences of the disease after it has become established.",
keywords = "Antihypertensive Agents, Arterioles, Biopsy, Capillary Resistance, Drug Evaluation, Drug Therapy, Combination, Female, Humans, Hypertension, Male, Middle Aged, Muscle Contraction, Skin, Time Factors, Vascular Resistance",
author = "Heagerty, {A M} and Bund, {S J} and Christian Aalkj{\ae}r",
year = "1988",
month = nov,
day = "26",
language = "English",
volume = "2",
pages = "1209--1212",
journal = "Lancet",
issn = "0140-6736",
publisher = "TheLancet Publishing Group",
number = "8622",

}

RIS

TY - JOUR

T1 - Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels

AU - Heagerty, A M

AU - Bund, S J

AU - Aalkjær, Christian

PY - 1988/11/26

Y1 - 1988/11/26

N2 - To examine whether effective drug treatment would reverse the morphological changes in resistance arterioles which characterise untreated essential hypertension, the vessels' media thickness and contractility were measured before and after long-term treatment. Nine patients underwent skin biopsy before and after a mean 13 months of antihypertensive treatment (range 4-24 months). Subcutaneous resistance arterioles were dissected and mounted in a myograph. Treatment did not affect the shift in sensitivity to noradrenaline in the presence of cocaine, sensitivity to exogenously administered calcium, and the rate of relaxation after withdrawal of vasoconstrictor stimuli. The media/lumen ratio fell significantly (p = 0.011) owing to a significant regression in media thickness (p = 0.0195), but this was not complete. Thus, effective antihypertensive treatment can reverse some of the structural change observed in the untreated state, although it apparently does not affect calcium sensitivity or relaxation rate; these features are thought to be consequences of the disease after it has become established.

AB - To examine whether effective drug treatment would reverse the morphological changes in resistance arterioles which characterise untreated essential hypertension, the vessels' media thickness and contractility were measured before and after long-term treatment. Nine patients underwent skin biopsy before and after a mean 13 months of antihypertensive treatment (range 4-24 months). Subcutaneous resistance arterioles were dissected and mounted in a myograph. Treatment did not affect the shift in sensitivity to noradrenaline in the presence of cocaine, sensitivity to exogenously administered calcium, and the rate of relaxation after withdrawal of vasoconstrictor stimuli. The media/lumen ratio fell significantly (p = 0.011) owing to a significant regression in media thickness (p = 0.0195), but this was not complete. Thus, effective antihypertensive treatment can reverse some of the structural change observed in the untreated state, although it apparently does not affect calcium sensitivity or relaxation rate; these features are thought to be consequences of the disease after it has become established.

KW - Antihypertensive Agents

KW - Arterioles

KW - Biopsy

KW - Capillary Resistance

KW - Drug Evaluation

KW - Drug Therapy, Combination

KW - Female

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Muscle Contraction

KW - Skin

KW - Time Factors

KW - Vascular Resistance

M3 - Journal article

C2 - 2903951

VL - 2

SP - 1209

EP - 1212

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 8622

ER -