Aarhus University Seal / Aarhus Universitets segl

Charlotte Birkmose Rotbøl

Måling af nyrefunktion under cytostatisk behandling.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Måling af nyrefunktion under cytostatisk behandling. / Hartlev, Louise Brøndt; Bøje, Charlotte Rotbøl; Bluhme, Henrik; Palshof, Torben; Rehling, Michael.

I: Ugeskrift for Laeger, Bind 170, Nr. 45, 2008, s. 3664-7.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hartlev, LB, Bøje, CR, Bluhme, H, Palshof, T & Rehling, M 2008, 'Måling af nyrefunktion under cytostatisk behandling.', Ugeskrift for Laeger, bind 170, nr. 45, s. 3664-7.

APA

Hartlev, L. B., Bøje, C. R., Bluhme, H., Palshof, T., & Rehling, M. (2008). Måling af nyrefunktion under cytostatisk behandling. Ugeskrift for Laeger, 170(45), 3664-7.

CBE

Hartlev LB, Bøje CR, Bluhme H, Palshof T, Rehling M. 2008. Måling af nyrefunktion under cytostatisk behandling. Ugeskrift for Laeger. 170(45):3664-7.

MLA

Hartlev, Louise Brøndt o.a.. "Måling af nyrefunktion under cytostatisk behandling.". Ugeskrift for Laeger. 2008, 170(45). 3664-7.

Vancouver

Hartlev LB, Bøje CR, Bluhme H, Palshof T, Rehling M. Måling af nyrefunktion under cytostatisk behandling. Ugeskrift for Laeger. 2008;170(45):3664-7.

Author

Hartlev, Louise Brøndt ; Bøje, Charlotte Rotbøl ; Bluhme, Henrik ; Palshof, Torben ; Rehling, Michael. / Måling af nyrefunktion under cytostatisk behandling. I: Ugeskrift for Laeger. 2008 ; Bind 170, Nr. 45. s. 3664-7.

Bibtex

@article{79325af0bbb911dd99a9000ea68e967b,
title = "M{\aa}ling af nyrefunktion under cytostatisk behandling.",
abstract = "INTRODUCTION: Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. MATERIALS AND METHODS: We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. RESULTS: Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. CONCLUSION: Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics. Udgivelsesdato: 2008-Nov-3",
keywords = "Adult, Aged, Antineoplastic Agents, Chromium Radioisotopes, Creatinine, Edetic Acid, Female, Glomerular Filtration Rate, Humans, Kidney, Male, Middle Aged, Neoplasms, Retrospective Studies",
author = "Hartlev, {Louise Br{\o}ndt} and B{\o}je, {Charlotte Rotb{\o}l} and Henrik Bluhme and Torben Palshof and Michael Rehling",
year = "2008",
language = "Dansk",
volume = "170",
pages = "3664--7",
journal = "Ugeskrift for L{\ae}ger",
issn = "0041-5782",
publisher = "Den Almindelige Danske L{\ae}geforening",
number = "45",

}

RIS

TY - JOUR

T1 - Måling af nyrefunktion under cytostatisk behandling.

AU - Hartlev, Louise Brøndt

AU - Bøje, Charlotte Rotbøl

AU - Bluhme, Henrik

AU - Palshof, Torben

AU - Rehling, Michael

PY - 2008

Y1 - 2008

N2 - INTRODUCTION: Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. MATERIALS AND METHODS: We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. RESULTS: Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. CONCLUSION: Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics. Udgivelsesdato: 2008-Nov-3

AB - INTRODUCTION: Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. MATERIALS AND METHODS: We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. RESULTS: Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. CONCLUSION: Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics. Udgivelsesdato: 2008-Nov-3

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Chromium Radioisotopes

KW - Creatinine

KW - Edetic Acid

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Retrospective Studies

M3 - Tidsskriftartikel

C2 - 18986617

VL - 170

SP - 3664

EP - 3667

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

SN - 0041-5782

IS - 45

ER -