Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Måling af nyrefunktion under cytostatisk behandling. / Hartlev, Louise Brøndt; Bøje, Charlotte Rotbøl; Bluhme, Henrik; Palshof, Torben; Rehling, Michael.
I: Ugeskrift for Laeger, Bind 170, Nr. 45, 2008, s. 3664-7.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Måling af nyrefunktion under cytostatisk behandling.
AU - Hartlev, Louise Brøndt
AU - Bøje, Charlotte Rotbøl
AU - Bluhme, Henrik
AU - Palshof, Torben
AU - Rehling, Michael
PY - 2008
Y1 - 2008
N2 - INTRODUCTION: Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. MATERIALS AND METHODS: We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. RESULTS: Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. CONCLUSION: Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics. Udgivelsesdato: 2008-Nov-3
AB - INTRODUCTION: Some cytostatics, used in the treatment of cancer, are excreted by the kidneys and may be nephrotoxic. The glomerular filtration rate (GFR) represents a method for reliable assessement of the 51Cr-EDTA plasma clearance before and during treatment with nephrotoxic drugs. The aim of this retrospective study was to evaluate whether this method could be replaced by a more simplified GFR estimate calculated from the creatinine plasma concentration. MATERIALS AND METHODS: We included all patients who had had at least four GFR measurements in 2005 as part of their nephrotoxic cytostatic treatment. The estimated GFR (eGFR) was calculated from sex, age and weight, according to the Cockcroft formula. RESULTS: Forty-eight patients with a mean age of 47 years were included. 51Cr-EDTA plasma clearance and eGFR showed a poor correlation (r(2) = 0,678). On average, GFR decreased from 95 ml/min to 80 ml/min from the first to the fourth measurement, whereas plasma concentration of creatinine and eGFR remained unchanged. In 13 patients (27%), the treatment dose was reduced due to a fall in GFR. Seven of these 13 patients would have continued their treatment unchanged, if the clinical decision had been based on eGFR. CONCLUSION: Neither creatinine plasma concentration nor estimated GFR ad modum Cockcroft can be recommended for measurement of GFR in patients treated with nephrotoxic cytostatics. Udgivelsesdato: 2008-Nov-3
KW - Adult
KW - Aged
KW - Antineoplastic Agents
KW - Chromium Radioisotopes
KW - Creatinine
KW - Edetic Acid
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Kidney
KW - Male
KW - Middle Aged
KW - Neoplasms
KW - Retrospective Studies
M3 - Tidsskriftartikel
C2 - 18986617
VL - 170
SP - 3664
EP - 3667
JO - Ugeskrift for Læger
JF - Ugeskrift for Læger
SN - 0041-5782
IS - 45
ER -