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Catherine Williams

The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)

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The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius). / Jakobsen, Sashia L.; Williams, Catherine J. A.; Wang, Tobias; Bertelsen, Mads F.

I: Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, Bind 207, 05.2017, s. 30-35.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Jakobsen, SL, Williams, CJA, Wang, T & Bertelsen, MF 2017, 'The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)', Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, bind 207, s. 30-35. https://doi.org/10.1016/j.cbpa.2017.02.012

APA

Jakobsen, S. L., Williams, C. J. A., Wang, T., & Bertelsen, M. F. (2017). The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius). Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 207, 30-35. https://doi.org/10.1016/j.cbpa.2017.02.012

CBE

Jakobsen SL, Williams CJA, Wang T, Bertelsen MF. 2017. The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius). Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 207:30-35. https://doi.org/10.1016/j.cbpa.2017.02.012

MLA

Jakobsen, Sashia L. o.a.. "The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)". Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 2017, 207. 30-35. https://doi.org/10.1016/j.cbpa.2017.02.012

Vancouver

Jakobsen SL, Williams CJA, Wang T, Bertelsen MF. The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius). Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 2017 maj;207:30-35. https://doi.org/10.1016/j.cbpa.2017.02.012

Author

Jakobsen, Sashia L. ; Williams, Catherine J. A. ; Wang, Tobias ; Bertelsen, Mads F. / The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius). I: Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 2017 ; Bind 207. s. 30-35.

Bibtex

@article{ca93545676ce4500b012b7619cefdb57,
title = "The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)",
abstract = "Mechanical ventilation is widely recommended for reptiles during anesthesia, and while it is well-known that their low ectothermic metabolism requires much lower ventilation than in mammals, very little is known about the influence of ventilation protocol on the recovery from anesthesia. Here, 15 ball pythons (Python regius) were induced and maintained with isoflurane for 60 min at one of three ventilation protocols (30, 125, or 250 ml min(-1) kg(-1) body mass) while an arterial catheter was inserted, and ventilation was then continued on 100{\%} oxygen at the specified rate until voluntary extubation. Mean arterial blood pressure and heart rate (HR) were measured, and arterial blood samples collected at 60, 80,180 min and 12 and 24 h after intubation. In all three groups, there was evidence of a metabolic acidosis, and snakes maintained at 30 ml min(-1) kg(-1), experienced an additional respiratory acidosis, while the two other ventilation protocols resulted in normal or low arterial PCO2. In general, normal acid-base status was restored within 12 h in all three protocols. HR increased by 143 +/- 64{\%} during anesthesia with high mechanical ventilation (250 ml min(-1) kg(-1)) in comparison with recovered values. Recovery times after mechanical ventilation at 30, 125, or 250 ml min(-1) kg(-1) were 289 +/- 70, 126 +/- 16, and 68 +/- 7 min, respectively. Mild overventilation may result in a faster recovery, and the associated lowering of arterial PCO2 normalised arterial pH in the face of metabolic acidosis. (C) 2017 Elsevier Inc. All rights reserved.",
keywords = "Anesthesia, Ventilation, Isoflurane, Acid-base balance, Python regius, Reptile, IGUANA IGUANA-IGUANA, NITROUS-OXIDE, GREEN IGUANAS, SEVOFLURANE ANESTHESIA, HEART-RATE, ISOFLURANE, RECOVERY, DIGESTION, MOLURUS, OXYGEN",
author = "Jakobsen, {Sashia L.} and Williams, {Catherine J. A.} and Tobias Wang and Bertelsen, {Mads F.}",
year = "2017",
month = "5",
doi = "10.1016/j.cbpa.2017.02.012",
language = "English",
volume = "207",
pages = "30--35",
journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",
issn = "1095-6433",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)

AU - Jakobsen, Sashia L.

AU - Williams, Catherine J. A.

AU - Wang, Tobias

AU - Bertelsen, Mads F.

PY - 2017/5

Y1 - 2017/5

N2 - Mechanical ventilation is widely recommended for reptiles during anesthesia, and while it is well-known that their low ectothermic metabolism requires much lower ventilation than in mammals, very little is known about the influence of ventilation protocol on the recovery from anesthesia. Here, 15 ball pythons (Python regius) were induced and maintained with isoflurane for 60 min at one of three ventilation protocols (30, 125, or 250 ml min(-1) kg(-1) body mass) while an arterial catheter was inserted, and ventilation was then continued on 100% oxygen at the specified rate until voluntary extubation. Mean arterial blood pressure and heart rate (HR) were measured, and arterial blood samples collected at 60, 80,180 min and 12 and 24 h after intubation. In all three groups, there was evidence of a metabolic acidosis, and snakes maintained at 30 ml min(-1) kg(-1), experienced an additional respiratory acidosis, while the two other ventilation protocols resulted in normal or low arterial PCO2. In general, normal acid-base status was restored within 12 h in all three protocols. HR increased by 143 +/- 64% during anesthesia with high mechanical ventilation (250 ml min(-1) kg(-1)) in comparison with recovered values. Recovery times after mechanical ventilation at 30, 125, or 250 ml min(-1) kg(-1) were 289 +/- 70, 126 +/- 16, and 68 +/- 7 min, respectively. Mild overventilation may result in a faster recovery, and the associated lowering of arterial PCO2 normalised arterial pH in the face of metabolic acidosis. (C) 2017 Elsevier Inc. All rights reserved.

AB - Mechanical ventilation is widely recommended for reptiles during anesthesia, and while it is well-known that their low ectothermic metabolism requires much lower ventilation than in mammals, very little is known about the influence of ventilation protocol on the recovery from anesthesia. Here, 15 ball pythons (Python regius) were induced and maintained with isoflurane for 60 min at one of three ventilation protocols (30, 125, or 250 ml min(-1) kg(-1) body mass) while an arterial catheter was inserted, and ventilation was then continued on 100% oxygen at the specified rate until voluntary extubation. Mean arterial blood pressure and heart rate (HR) were measured, and arterial blood samples collected at 60, 80,180 min and 12 and 24 h after intubation. In all three groups, there was evidence of a metabolic acidosis, and snakes maintained at 30 ml min(-1) kg(-1), experienced an additional respiratory acidosis, while the two other ventilation protocols resulted in normal or low arterial PCO2. In general, normal acid-base status was restored within 12 h in all three protocols. HR increased by 143 +/- 64% during anesthesia with high mechanical ventilation (250 ml min(-1) kg(-1)) in comparison with recovered values. Recovery times after mechanical ventilation at 30, 125, or 250 ml min(-1) kg(-1) were 289 +/- 70, 126 +/- 16, and 68 +/- 7 min, respectively. Mild overventilation may result in a faster recovery, and the associated lowering of arterial PCO2 normalised arterial pH in the face of metabolic acidosis. (C) 2017 Elsevier Inc. All rights reserved.

KW - Anesthesia

KW - Ventilation

KW - Isoflurane

KW - Acid-base balance

KW - Python regius

KW - Reptile

KW - IGUANA IGUANA-IGUANA

KW - NITROUS-OXIDE

KW - GREEN IGUANAS

KW - SEVOFLURANE ANESTHESIA

KW - HEART-RATE

KW - ISOFLURANE

KW - RECOVERY

KW - DIGESTION

KW - MOLURUS

KW - OXYGEN

U2 - 10.1016/j.cbpa.2017.02.012

DO - 10.1016/j.cbpa.2017.02.012

M3 - Journal article

C2 - 28192243

VL - 207

SP - 30

EP - 35

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

SN - 1095-6433

ER -