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Bjarni Jóhann Vilhjálmsson

The nature of nurture: Effects of parental genotypes

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The nature of nurture : Effects of parental genotypes. / Kong, Augustine; Thorleifsson, Gudmar; Frigge, Michael L.; Vilhjalmsson, Bjarni J.; Young, Alexander I.; Thorgeirsson, Thorgeir E.; Benonisdottir, Stefania; Oddsson, Asmundur; Halldorsson, Bjarni V.; Masson, Gisli; Gudbjartsson, Daniel F.; Helgason, Agnar; Bjornsdottir, Gyda; Thorsteinsdottir, Unnur; Stefansson, Kari.

I: Science, Bind 359, Nr. 6374, 26.01.2018, s. 424-428.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kong, A, Thorleifsson, G, Frigge, ML, Vilhjalmsson, BJ, Young, AI, Thorgeirsson, TE, Benonisdottir, S, Oddsson, A, Halldorsson, BV, Masson, G, Gudbjartsson, DF, Helgason, A, Bjornsdottir, G, Thorsteinsdottir, U & Stefansson, K 2018, 'The nature of nurture: Effects of parental genotypes', Science, bind 359, nr. 6374, s. 424-428. https://doi.org/10.1126/science.aan6877

APA

Kong, A., Thorleifsson, G., Frigge, M. L., Vilhjalmsson, B. J., Young, A. I., Thorgeirsson, T. E., ... Stefansson, K. (2018). The nature of nurture: Effects of parental genotypes. Science, 359(6374), 424-428. https://doi.org/10.1126/science.aan6877

CBE

Kong A, Thorleifsson G, Frigge ML, Vilhjalmsson BJ, Young AI, Thorgeirsson TE, Benonisdottir S, Oddsson A, Halldorsson BV, Masson G, Gudbjartsson DF, Helgason A, Bjornsdottir G, Thorsteinsdottir U, Stefansson K. 2018. The nature of nurture: Effects of parental genotypes. Science. 359(6374):424-428. https://doi.org/10.1126/science.aan6877

MLA

Vancouver

Kong A, Thorleifsson G, Frigge ML, Vilhjalmsson BJ, Young AI, Thorgeirsson TE o.a. The nature of nurture: Effects of parental genotypes. Science. 2018 jan 26;359(6374):424-428. https://doi.org/10.1126/science.aan6877

Author

Kong, Augustine ; Thorleifsson, Gudmar ; Frigge, Michael L. ; Vilhjalmsson, Bjarni J. ; Young, Alexander I. ; Thorgeirsson, Thorgeir E. ; Benonisdottir, Stefania ; Oddsson, Asmundur ; Halldorsson, Bjarni V. ; Masson, Gisli ; Gudbjartsson, Daniel F. ; Helgason, Agnar ; Bjornsdottir, Gyda ; Thorsteinsdottir, Unnur ; Stefansson, Kari. / The nature of nurture : Effects of parental genotypes. I: Science. 2018 ; Bind 359, Nr. 6374. s. 424-428.

Bibtex

@article{f74316e04172430a840f554f789aaba0,
title = "The nature of nurture: Effects of parental genotypes",
abstract = "Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call {"}genetic nurture.{"} Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9{\%} (P = 1.6 × 10-14) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition- and heath-related traits.",
author = "Augustine Kong and Gudmar Thorleifsson and Frigge, {Michael L.} and Vilhjalmsson, {Bjarni J.} and Young, {Alexander I.} and Thorgeirsson, {Thorgeir E.} and Stefania Benonisdottir and Asmundur Oddsson and Halldorsson, {Bjarni V.} and Gisli Masson and Gudbjartsson, {Daniel F.} and Agnar Helgason and Gyda Bjornsdottir and Unnur Thorsteinsdottir and Kari Stefansson",
year = "2018",
month = "1",
day = "26",
doi = "10.1126/science.aan6877",
language = "English",
volume = "359",
pages = "424--428",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6374",

}

RIS

TY - JOUR

T1 - The nature of nurture

T2 - Effects of parental genotypes

AU - Kong, Augustine

AU - Thorleifsson, Gudmar

AU - Frigge, Michael L.

AU - Vilhjalmsson, Bjarni J.

AU - Young, Alexander I.

AU - Thorgeirsson, Thorgeir E.

AU - Benonisdottir, Stefania

AU - Oddsson, Asmundur

AU - Halldorsson, Bjarni V.

AU - Masson, Gisli

AU - Gudbjartsson, Daniel F.

AU - Helgason, Agnar

AU - Bjornsdottir, Gyda

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

PY - 2018/1/26

Y1 - 2018/1/26

N2 - Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call "genetic nurture." Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9% (P = 1.6 × 10-14) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition- and heath-related traits.

AB - Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call "genetic nurture." Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9% (P = 1.6 × 10-14) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition- and heath-related traits.

UR - http://www.scopus.com/inward/record.url?scp=85040991713&partnerID=8YFLogxK

U2 - 10.1126/science.aan6877

DO - 10.1126/science.aan6877

M3 - Journal article

VL - 359

SP - 424

EP - 428

JO - Science

JF - Science

SN - 0036-8075

IS - 6374

ER -