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Bjarni Jóhann Vilhjálmsson

Genome-wide association study of Arabidopsis thaliana leaf microbial community

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  • Matthew W Horton, Ukendt
  • Natacha Bodenhausen, Ukendt
  • Kathleen Beilsmith, Ukendt
  • Dazhe Meng, Ukendt
  • Brian D Muegge, Ukendt
  • Sathish Subramanian, Ukendt
  • M Madlen Vetter, Ukendt
  • Bjarni Jóhann Vilhjálmsson
  • Magnus Nordborg, Ukendt
  • Jeffrey I Gordon, Ukendt
  • Joy Bergelson, Ukendt

Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind5
Sider (fra-til)5320
ISSN2041-1723
DOI
StatusUdgivet - 2014
Eksternt udgivetJa

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