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Bjarke Nørrehvedde Jensen

Injectable 2D flexible hydrogel sheets for optoelectrical/biochemical dual stimulation of neurons

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Jordi Amagat
    • ,
  • Christoph Alexander Müller
  • Bjarke Nørrehvedde Jensen
  • Xuya Xiong
    • ,
  • Yingchun Su
    • ,
  • Natasja Porskjær Christensen, Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus University, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Psychiatric Department, Aarhus University Hospital, Aarhus, Denmark.
    • ,
  • Alice Le Friec
    • ,
  • Mingdong Dong
  • Ying Fang, Chinese Academy of Social Sciences
    • ,
  • Menglin Chen

Major challenges in developing implanted neural stimulation devices are the invasiveness, complexity, and cost of the implantation procedure. Here, we report an injectable, nanofibrous 2D flexible hydrogel sheet-based neural stimulation device that can be non-invasively implanted via syringe injection for optoelectrical and biochemical dual stimulation of neuron. Specifically, methacrylated gelatin (GelMA)/alginate hydrogel nanofibers were mechanically reinforced with a poly(lactide-co-ε-caprolactone) (PLCL) core by coaxial electrospinning. The lubricant hydrogel shell enabled not only injectability, but also facile incorporation of functional nanomaterials and bioactives. The nanofibers loaded with photocatatlytic g-C 3N 4/GO nanoparticles were capable of stimulating neural cells via blue light, with a significant 36.3 % enhancement in neurite extension. Meanwhile, the nerve growth factor (NGF) loaded nanofibers supported a sustained release of NGF with well-maintained function to biochemically stimulate neural differentiation. We have demonstrated the capability of an injectable, hydrogel nanofibrous, neural stimulation system to support neural stimulation both optoelectrically and biochemically, which represents crucial early steps in a larger effort to create a minimally invasive system for neural stimulation.

OriginalsprogEngelsk
Artikelnummer213284
TidsskriftBiomaterials advances
Vol/bind146
Sider (fra-til)213284
ISSN2772-9508
DOI
StatusE-pub ahead of print - 7 jan. 2023

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Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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