Asbjørn Mohr Drewes

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • J. Matthias Lohr, Karolinska Univ Hosp, Karolinska University Hospital, Karolinska Institutet, Ctr Digest Dis
  • ,
  • Enrique Dominguez-Munoz, Univ Hosp Santiago Compostela, Complexo Hospitalario Universitario de Santiago de Compostela, Dept Gastroenterol & Hepatol
  • ,
  • Jonas Rosendahl, Univ Leipzig, University of Leipzig, Dept Gastroenterol
  • ,
  • Marc Besselink, Acad Med Ctr Amsterdam, Dept Surg
  • ,
  • Julia Mayerle
  • ,
  • Markus M. Lerch, Univ Med Greifswald, Dept Med
  • ,
  • Stephan Haas, Karolinska Univ Hosp, Karolinska University Hospital, Karolinska Institutet, Ctr Digest Dis
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  • Fatih Akisik, Indiana Univ, Indiana University System, Indiana University-Purdue University Indianapolis, Dept Radiol
  • ,
  • Nikolaos Kartalis, Karolinska Inst, Karolinska Institutet, CLINTEC, Div Med Imaging & Technol
  • ,
  • Julio Iglesias-Garcia, Univ Hosp Santiago Compostela, Complexo Hospitalario Universitario de Santiago de Compostela, Dept Gastroenterol & Hepatol
  • ,
  • Jutta Keller, Univ Hamburg, University of Hamburg, Israelit Hosp Hamburg
  • ,
  • Marja Boermeester, Acad Med Ctr Amsterdam, Dept Surg
  • ,
  • Jens Werner, Ludwig Maximilians Univ Munchen, University of Munich
  • ,
  • Jean-Marc Dumonceau, Univ Geneva, University of Geneva, Observ Geneva
  • ,
  • Paul Fockens, Acad Med Ctr, Dept Gastroenterol & Hepatol
  • ,
  • Asbjorn Drewes
  • Guerlap Ceyhan, Tech Univ Munich, Technical University of Munich, Klinikum Rechts Isar
  • ,
  • Bjorn Lindkvist, Univ Gothenburg, University of Gothenburg, Inst Hlth & Care Sci
  • ,
  • Joost P. H. Drenth, Radboud Univ Nijmegen, Radboud University Nijmegen, Med Ctr, Dept Gastroenterol & Hepatol
  • ,
  • Nils Ewald, Justus Liebig Univ Giessen, Justus Liebig University Giessen, Dept Dermatol & Allergol, Univ Med Ctr Giessen & Marburg
  • ,
  • Philip Hardt, Justus Liebig Univ Giessen, Justus Liebig University Giessen, Dept Dermatol & Allergol, Univ Med Ctr Giessen & Marburg
  • ,
  • Enrique de Madaria, Hosp Gen Univ, Universitat d'Alacant
  • ,
  • Heiko Witt, Tech Univ Munich, Technical University of Munich, Excellence Cluster Univ
  • ,
  • Alexander Schneider, Univ Hosp Mannheim, Ruprecht Karl University Heidelberg
  • ,
  • Riccardo Manfredi, Univ Verona, University of Verona, Dept Radiol
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  • Frokjer J. Brondum, Aalborg Univ, Aalborg University, Dept Chem & Biosci
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  • Sasa Rudolf, Univ Med Ctr Maribor, Dept Radiol
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  • Thomas Bollen, St Antonius Hosp, St. Antonius Hospital Utrecht
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  • Marco Bruno, Klinikum Ludwig Maximilians Univ, University of Munich, Med Klin & Poliklin 2
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  • HaPanEU UEG Working Grp

Background:There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed these European guidelines using an evidence-based approach.

Methods: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.

Results: The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as strong' and plenary voting revealed strong agreement' for 99 (98%) recommendations.

Conclusions:The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

OriginalsprogEngelsk
TidsskriftUnited European Gastroenterology Journal
Vol/bind5
Nummer2
Sider (fra-til)153-199
Antal sider47
ISSN2050-6406
DOI
StatusUdgivet - mar. 2017

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