Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers. / Krarup, Anne L; Simrén, Magnus; Funch-Jensen, Peter; Berner-Hansen, Mark; Hvid-Jensen, Frederik; Brun, Jan; Drewes, Asbjørn M.

I: Digestive Diseases and Sciences, Bind 56, Nr. 7, 08.01.2011, s. 1967-75.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Krarup, AL, Simrén, M, Funch-Jensen, P, Berner-Hansen, M, Hvid-Jensen, F, Brun, J & Drewes, AM 2011, 'The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers', Digestive Diseases and Sciences, bind 56, nr. 7, s. 1967-75. https://doi.org/10.1007/s10620-010-1546-1

APA

Krarup, A. L., Simrén, M., Funch-Jensen, P., Berner-Hansen, M., Hvid-Jensen, F., Brun, J., & Drewes, A. M. (2011). The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers. Digestive Diseases and Sciences, 56(7), 1967-75. https://doi.org/10.1007/s10620-010-1546-1

CBE

MLA

Vancouver

Krarup AL, Simrén M, Funch-Jensen P, Berner-Hansen M, Hvid-Jensen F, Brun J o.a. The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers. Digestive Diseases and Sciences. 2011 jan 8;56(7):1967-75. https://doi.org/10.1007/s10620-010-1546-1

Author

Krarup, Anne L ; Simrén, Magnus ; Funch-Jensen, Peter ; Berner-Hansen, Mark ; Hvid-Jensen, Frederik ; Brun, Jan ; Drewes, Asbjørn M. / The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers. I: Digestive Diseases and Sciences. 2011 ; Bind 56, Nr. 7. s. 1967-75.

Bibtex

@article{e6ef9da73890464fbd368152f3864adc,
title = "The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers",
abstract = "BACKGROUND: Sensory changes are thought to be involved in gastro-esophageal reflux disease (GERD). The esophageal multimodal pain model can be used to investigate sensations in response to distension, heat, electric current and acid. AIMS: The aim of this study was to provide normal values for this model in the normal state and in the acid induced sensitized state. METHODS: Fifty-three healthy men (20-38 years old) underwent esophageal stimulation with distension, heat and electrical current before and after sensitization with 0.1 N HCl acid. Stimulus intensities at painful and non-painful thresholds and referred pain areas were measured. The percentage of individual participants sensitized to each modality was calculated. In 22 subjects the pre-acid tests were repeated on three subsequent visits. RESULTS: To reach moderate pain, subjects tolerated mean distension of 29.1 ± 11 mL, heat stimulation time of 141 ± 33 s, and mean current of 17.6 ± 6.4 mA. After acid exposure, significantly reduced thresholds were observed for mechanical (24%), heat (11%) and electrical (14%) stimulation (P values 0.6). CONCLUSIONS: Normal values for healthy young men are now provided for the normal and the sensitized state. The percentage of subjects sensitized after acid stimulation are thoroughly documented, and depends on stimulation type and the cut-off value chosen.",
author = "Krarup, {Anne L} and Magnus Simr{\'e}n and Peter Funch-Jensen and Mark Berner-Hansen and Frederik Hvid-Jensen and Jan Brun and Drewes, {Asbj{\o}rn M}",
year = "2011",
month = jan,
day = "8",
doi = "10.1007/s10620-010-1546-1",
language = "English",
volume = "56",
pages = "1967--75",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York LLC",
number = "7",

}

RIS

TY - JOUR

T1 - The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers

AU - Krarup, Anne L

AU - Simrén, Magnus

AU - Funch-Jensen, Peter

AU - Berner-Hansen, Mark

AU - Hvid-Jensen, Frederik

AU - Brun, Jan

AU - Drewes, Asbjørn M

PY - 2011/1/8

Y1 - 2011/1/8

N2 - BACKGROUND: Sensory changes are thought to be involved in gastro-esophageal reflux disease (GERD). The esophageal multimodal pain model can be used to investigate sensations in response to distension, heat, electric current and acid. AIMS: The aim of this study was to provide normal values for this model in the normal state and in the acid induced sensitized state. METHODS: Fifty-three healthy men (20-38 years old) underwent esophageal stimulation with distension, heat and electrical current before and after sensitization with 0.1 N HCl acid. Stimulus intensities at painful and non-painful thresholds and referred pain areas were measured. The percentage of individual participants sensitized to each modality was calculated. In 22 subjects the pre-acid tests were repeated on three subsequent visits. RESULTS: To reach moderate pain, subjects tolerated mean distension of 29.1 ± 11 mL, heat stimulation time of 141 ± 33 s, and mean current of 17.6 ± 6.4 mA. After acid exposure, significantly reduced thresholds were observed for mechanical (24%), heat (11%) and electrical (14%) stimulation (P values 0.6). CONCLUSIONS: Normal values for healthy young men are now provided for the normal and the sensitized state. The percentage of subjects sensitized after acid stimulation are thoroughly documented, and depends on stimulation type and the cut-off value chosen.

AB - BACKGROUND: Sensory changes are thought to be involved in gastro-esophageal reflux disease (GERD). The esophageal multimodal pain model can be used to investigate sensations in response to distension, heat, electric current and acid. AIMS: The aim of this study was to provide normal values for this model in the normal state and in the acid induced sensitized state. METHODS: Fifty-three healthy men (20-38 years old) underwent esophageal stimulation with distension, heat and electrical current before and after sensitization with 0.1 N HCl acid. Stimulus intensities at painful and non-painful thresholds and referred pain areas were measured. The percentage of individual participants sensitized to each modality was calculated. In 22 subjects the pre-acid tests were repeated on three subsequent visits. RESULTS: To reach moderate pain, subjects tolerated mean distension of 29.1 ± 11 mL, heat stimulation time of 141 ± 33 s, and mean current of 17.6 ± 6.4 mA. After acid exposure, significantly reduced thresholds were observed for mechanical (24%), heat (11%) and electrical (14%) stimulation (P values 0.6). CONCLUSIONS: Normal values for healthy young men are now provided for the normal and the sensitized state. The percentage of subjects sensitized after acid stimulation are thoroughly documented, and depends on stimulation type and the cut-off value chosen.

U2 - 10.1007/s10620-010-1546-1

DO - 10.1007/s10620-010-1546-1

M3 - Journal article

C2 - 21221787

VL - 56

SP - 1967

EP - 1975

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 7

ER -