Asbjørn Mohr Drewes

Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Regional gastrointestinal contractility parameters using the wireless motility capsule : inter-observer reproducibility and influence of age, gender and study country. / Farmer, A. D.; Wegeberg, A. M.L.; Brock, B.; Hobson, A. R.; Mohammed, S. D.; Scott, S. M.; Bruckner-Holt, C. E.; Semler, J. R.; Hasler, W. L.; Hellström, P. M.; Drewes, A. M.; Brock, C.

I: Alimentary Pharmacology and Therapeutics, Bind 47, Nr. 3, 01.02.2018, s. 391-400.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Farmer, AD, Wegeberg, AML, Brock, B, Hobson, AR, Mohammed, SD, Scott, SM, Bruckner-Holt, CE, Semler, JR, Hasler, WL, Hellström, PM, Drewes, AM & Brock, C 2018, 'Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country', Alimentary Pharmacology and Therapeutics, bind 47, nr. 3, s. 391-400. https://doi.org/10.1111/apt.14438

APA

Farmer, A. D., Wegeberg, A. M. L., Brock, B., Hobson, A. R., Mohammed, S. D., Scott, S. M., Bruckner-Holt, C. E., Semler, J. R., Hasler, W. L., Hellström, P. M., Drewes, A. M., & Brock, C. (2018). Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. Alimentary Pharmacology and Therapeutics, 47(3), 391-400. https://doi.org/10.1111/apt.14438

CBE

Farmer AD, Wegeberg AML, Brock B, Hobson AR, Mohammed SD, Scott SM, Bruckner-Holt CE, Semler JR, Hasler WL, Hellström PM, Drewes AM, Brock C. 2018. Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. Alimentary Pharmacology and Therapeutics. 47(3):391-400. https://doi.org/10.1111/apt.14438

MLA

Vancouver

Farmer AD, Wegeberg AML, Brock B, Hobson AR, Mohammed SD, Scott SM o.a. Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. Alimentary Pharmacology and Therapeutics. 2018 feb 1;47(3):391-400. https://doi.org/10.1111/apt.14438

Author

Farmer, A. D. ; Wegeberg, A. M.L. ; Brock, B. ; Hobson, A. R. ; Mohammed, S. D. ; Scott, S. M. ; Bruckner-Holt, C. E. ; Semler, J. R. ; Hasler, W. L. ; Hellström, P. M. ; Drewes, A. M. ; Brock, C. / Regional gastrointestinal contractility parameters using the wireless motility capsule : inter-observer reproducibility and influence of age, gender and study country. I: Alimentary Pharmacology and Therapeutics. 2018 ; Bind 47, Nr. 3. s. 391-400.

Bibtex

@article{7db403f926c1426c9dd367d191f0e843,
title = "Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country",
abstract = " Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r =.24, P =.01; r =.22, P =.02; and r =.2, P =.04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P =.04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log e motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P <.0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders. ",
author = "Farmer, {A. D.} and Wegeberg, {A. M.L.} and B. Brock and Hobson, {A. R.} and Mohammed, {S. D.} and Scott, {S. M.} and Bruckner-Holt, {C. E.} and Semler, {J. R.} and Hasler, {W. L.} and Hellstr{\"o}m, {P. M.} and Drewes, {A. M.} and C. Brock",
year = "2018",
month = feb,
day = "1",
doi = "10.1111/apt.14438",
language = "English",
volume = "47",
pages = "391--400",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Regional gastrointestinal contractility parameters using the wireless motility capsule

T2 - inter-observer reproducibility and influence of age, gender and study country

AU - Farmer, A. D.

AU - Wegeberg, A. M.L.

AU - Brock, B.

AU - Hobson, A. R.

AU - Mohammed, S. D.

AU - Scott, S. M.

AU - Bruckner-Holt, C. E.

AU - Semler, J. R.

AU - Hasler, W. L.

AU - Hellström, P. M.

AU - Drewes, A. M.

AU - Brock, C.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r =.24, P =.01; r =.22, P =.02; and r =.2, P =.04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P =.04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log e motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P <.0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.

AB - Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r =.24, P =.01; r =.22, P =.02; and r =.2, P =.04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P =.04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log e motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P <.0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.

UR - http://www.scopus.com/inward/record.url?scp=85037641742&partnerID=8YFLogxK

U2 - 10.1111/apt.14438

DO - 10.1111/apt.14438

M3 - Journal article

C2 - 29210098

AN - SCOPUS:85037641742

VL - 47

SP - 391

EP - 400

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 3

ER -