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Asbjørn Mohr Drewes

Reduced Cortical Thickness of Brain Areas Involved in Pain Processing in Patients with Chronic Pancreatitis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Jens Brøndum Frøkjær
  • ,
  • Stefan A W Bouwense
  • ,
  • Søren Schou Olesen
  • ,
  • Flemming H Lundager
  • ,
  • Simon Fristed Eskildsen
  • ,
  • Harry van Goor
  • ,
  • Oliver Wilder-Smith
  • ,
  • Asbjørn Mohr Drewes
BACKGROUND & AIMS: Patients with painful chronic pancreatitis (CP) might have abnormal brain function. We assessed cortical thickness in brain areas involved in visceral pain processing. METHODS: We analyzed brain morphologies of 19 patients with painful CP and compared them with 15 healthy individuals (controls) using a 3T magnetic resonance scanner. We assessed cortical thickness, using an automated method with surface-based cortical segmentation, of the primary (SI) and secondary (SII) somatosensory cortex, prefrontal cortex (PFC), frontal cortex (FC), anterior (ACC), mid (MCC), and posterior (PCC) cingulate cortex, and insula. The occipital middle sulcus was used as control area. The pain score was determined based on the average daily amount of pain during 1 week. RESULTS: Compared to controls, patients with CP had reduced overall cortical thickness (P =.0012), without effects of modification for diabetes, alcoholic etiologies, or opioid treatment (all P -values>0.05). In patients with CP, the cortical thickness was decreased in SII (P =.002, compared with controls), PFC ( P =.046), FC (P =.0003), MCC (P =.001), and insula (P =.002). There were no differences in cortical thickness between CP patients and controls in the control area (P =.20), SI (P =.06), ACC (P =.95), or PCC ( P =.42). Cortical thickness in the affected areas correlated with pain score (r=.47, P =.003). CONCLUSIONS: In patients with CP, brain areas involved in pain processing have reduced cortical thickness. Cortical thickness might, as a result of long-term, ongoing pain input to the neuromatrix, serve as a measure for overall pain system dysfunction, as observed in other diseases characterized by chronic pain.
OriginalsprogEngelsk
TidsskriftClinical Gastroenterology and Hepatology
Vol/bind10
Nummer4
Sider (fra-til)434-8
Antal sider5
ISSN1542-3565
DOI
StatusUdgivet - 2012

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