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Asbjørn Mohr Drewes

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

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  • Medicinsk Gastroenterologisk Afdeling, Medicinsk Center, Aalborg Sygehus
  • Kirurgisk Afdeling L, NBG
  • Center for visceral biomekanik og smerte, AAL
Aliment Pharmacol Ther 2011; 33: 1113-1122 SUMMARY: Background  Many patients with gastro-oesophageal reflux disease (GERD) are hypersensitive to heat and acid and may respond insufficiently to standard treatment. Antagonists of the heat and acid receptor 'transient receptor potential vanilloid 1'(TRPV1) are a potential drug class for GERD treatment. Aim  To investigate the effect of a TRPV1 antagonist (AZD1386) on experimentally induced oesophageal pain. Methods  Twenty-two healthy men (20-31 years) participated in this randomised, placebo-controlled, double-blinded, crossover study examining the effects of a single-dose oral AZD1386 (30 and 95 mg). Subjects were block-randomised. On treatment days, participants were stimulated with painful heat, distension, electrical current and acid in the oesophagus. Heat and pressure pain on the forearm were somatic control stimuli. Data analysis: intention-to-treat. Results  A total of 21 participants completed the protocol and 1 voluntarily discontinued. In the oesophagus, both 30 and 95 mg of AZD1386 increased pain thresholds to heat stimuli 23% [95% confidence interval (CI): 10-38%] and 28%, respectively (CI: 14-43%). The skin heat tolerance was increased 2.1 °C (CI: 1.1-3.2 °C) after 30 mg AZD1386 and 4.0 °C (CI: 3.0-5.0 °C) after 95 mg. Heat analgesia persisted for 2.5 h. Pain thresholds to the other stimuli were unaffected by AZD1386. 50% reported 'feeling cold' and body temperature increased in all subjects exposed to 30 and 95 mg AZD1386 (mean increase 0.4 ± 0.3 °C and 0.7 ± 0.3 °C, respectively, P 
OriginalsprogEngelsk
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind33
Nummer10
Sider (fra-til)1113-22
Antal sider10
ISSN0269-2813
DOI
StatusUdgivet - 1 maj 2011

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