Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus. / Liao, Donghua; Krarup, Anne Lund; Lundager, Flemming Holbæk; Drewes, Asbjørn Mohr; Gregersen, Hans.

I: Digestive Diseases and Sciences, 28.02.2014.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Liao, Donghua ; Krarup, Anne Lund ; Lundager, Flemming Holbæk ; Drewes, Asbjørn Mohr ; Gregersen, Hans. / Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus. I: Digestive Diseases and Sciences. 2014.

Bibtex

@article{7d3ea755ac714f6c84ae392312fba3ba,
title = "Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus",
abstract = "BACKGROUND AND AIMS: Differences in contraction characteristics between primary and secondary peristalsis have only been scarcely studied. Recently new measures of contractile activity in the human esophagus were developed. The study aims were to use combined manometry and impedance planimetry [pressure-cross-sectional area (P-CSA)] recordings from healthy volunteers to examine esophageal peristalsis, and, furthermore, to investigate the effect of the motility enhancing drug erythromycin to study differential effects on the two types of contractions.METHODS: Sixteen healthy volunteers participated in the study [mean age 23 (range, 19-34) years, 6 females]. An esophageal probe with a bag for CSA measurement was positioned 10 cm above the lower esophageal sphincter. Bag volume was increased stepwise from 5 to 25 ml before and after intravenous infusion of 250 mg erythromycin. Swallow-evoked primary and distension-evoked secondary esophageal peristalsis were compared with regard to (1) pressure amplitude, (2) CSA amplitude, (3) preload tension (wall tension before an evoked contraction), (4) contractile tension, and (5) work outputs.RESULTS: Primary peristalsis induced more efficient contractions as the contraction amplitudes, work output and contractile tension were higher compared to secondary peristalsis (P < 0.001). Erythromycin induced change in CSA during distension-evoked secondary peristalsis (CSA before 212.9 ± 26.8 vs. after 180.5 ± 23.3, P < 0.05). The sensitivity to esophageal distension increased with the distending volume both before and during erythromycin. The sensitivity was not changed by erythromycin (P = 0.6).CONCLUSIONS: Esophageal primary peristaltic contractions were more forceful with longer duration, and higher work output compared to secondary peristalsis contractions. Erythromycin affected peristalsis only to a minor degree.",
author = "Donghua Liao and Krarup, {Anne Lund} and Lundager, {Flemming Holb{\ae}k} and Drewes, {Asbj{\o}rn Mohr} and Hans Gregersen",
year = "2014",
month = feb,
day = "28",
doi = "10.1007/s10620-014-3070-1",
language = "English",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York LLC",

}

RIS

TY - JOUR

T1 - Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus

AU - Liao, Donghua

AU - Krarup, Anne Lund

AU - Lundager, Flemming Holbæk

AU - Drewes, Asbjørn Mohr

AU - Gregersen, Hans

PY - 2014/2/28

Y1 - 2014/2/28

N2 - BACKGROUND AND AIMS: Differences in contraction characteristics between primary and secondary peristalsis have only been scarcely studied. Recently new measures of contractile activity in the human esophagus were developed. The study aims were to use combined manometry and impedance planimetry [pressure-cross-sectional area (P-CSA)] recordings from healthy volunteers to examine esophageal peristalsis, and, furthermore, to investigate the effect of the motility enhancing drug erythromycin to study differential effects on the two types of contractions.METHODS: Sixteen healthy volunteers participated in the study [mean age 23 (range, 19-34) years, 6 females]. An esophageal probe with a bag for CSA measurement was positioned 10 cm above the lower esophageal sphincter. Bag volume was increased stepwise from 5 to 25 ml before and after intravenous infusion of 250 mg erythromycin. Swallow-evoked primary and distension-evoked secondary esophageal peristalsis were compared with regard to (1) pressure amplitude, (2) CSA amplitude, (3) preload tension (wall tension before an evoked contraction), (4) contractile tension, and (5) work outputs.RESULTS: Primary peristalsis induced more efficient contractions as the contraction amplitudes, work output and contractile tension were higher compared to secondary peristalsis (P < 0.001). Erythromycin induced change in CSA during distension-evoked secondary peristalsis (CSA before 212.9 ± 26.8 vs. after 180.5 ± 23.3, P < 0.05). The sensitivity to esophageal distension increased with the distending volume both before and during erythromycin. The sensitivity was not changed by erythromycin (P = 0.6).CONCLUSIONS: Esophageal primary peristaltic contractions were more forceful with longer duration, and higher work output compared to secondary peristalsis contractions. Erythromycin affected peristalsis only to a minor degree.

AB - BACKGROUND AND AIMS: Differences in contraction characteristics between primary and secondary peristalsis have only been scarcely studied. Recently new measures of contractile activity in the human esophagus were developed. The study aims were to use combined manometry and impedance planimetry [pressure-cross-sectional area (P-CSA)] recordings from healthy volunteers to examine esophageal peristalsis, and, furthermore, to investigate the effect of the motility enhancing drug erythromycin to study differential effects on the two types of contractions.METHODS: Sixteen healthy volunteers participated in the study [mean age 23 (range, 19-34) years, 6 females]. An esophageal probe with a bag for CSA measurement was positioned 10 cm above the lower esophageal sphincter. Bag volume was increased stepwise from 5 to 25 ml before and after intravenous infusion of 250 mg erythromycin. Swallow-evoked primary and distension-evoked secondary esophageal peristalsis were compared with regard to (1) pressure amplitude, (2) CSA amplitude, (3) preload tension (wall tension before an evoked contraction), (4) contractile tension, and (5) work outputs.RESULTS: Primary peristalsis induced more efficient contractions as the contraction amplitudes, work output and contractile tension were higher compared to secondary peristalsis (P < 0.001). Erythromycin induced change in CSA during distension-evoked secondary peristalsis (CSA before 212.9 ± 26.8 vs. after 180.5 ± 23.3, P < 0.05). The sensitivity to esophageal distension increased with the distending volume both before and during erythromycin. The sensitivity was not changed by erythromycin (P = 0.6).CONCLUSIONS: Esophageal primary peristaltic contractions were more forceful with longer duration, and higher work output compared to secondary peristalsis contractions. Erythromycin affected peristalsis only to a minor degree.

U2 - 10.1007/s10620-014-3070-1

DO - 10.1007/s10620-014-3070-1

M3 - Journal article

C2 - 24682721

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

ER -