Asbjørn Mohr Drewes

Quantification and variability in colonic volume with a novel magnetic resonance imaging method

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • M Nilsson
  • Thomas Holm Sandberg, Aalborg Universitet, Danmark
  • Jakob Lykke Poulsen, Aalborg Universitet, Danmark
  • M Gram
  • ,
  • J.B. Frøkjær
  • ,
  • L.R. Østergaard, Department of Health Science and Technology, Aalborg University
  • ,
  • K Krogh
  • Christina Brock, Aalborg Universitet, Københavns Universitet, Danmark
  • Asbjørn Mohr Drewes

BACKGROUND: Segmental distribution of colorectal volume is relevant in a number of diseases, but clinical and experimental use demands robust reliability and validity. Using a novel semi-automatic magnetic resonance imaging-based technique, the aims of this study were to describe: (i) inter-individual and intra-individual variability of segmental colorectal volumes between two observations in healthy subjects and (ii) the change in segmental colorectal volume distribution before and after defecation.

METHODS: The inter-individual and intra-individual variability of four colorectal volumes (cecum/ascending colon, transverse, descending, and rectosigmoid colon) between two observations (separated by 52 ± 10) days was assessed in 25 healthy males and the effect of defecation on segmental colorectal volumes was studied in another seven healthy males.

KEY RESULTS: No significant differences between the two observations were detected for any segments (All p > 0.05). Inter-individual variability varied across segments from low correlation in cecum/ascending colon (intra-class correlation coefficient [ICC] = 0.44) to moderate correlation in the descending colon (ICC = 0.61) and high correlation in the transverse (ICC = 0.78), rectosigmoid (ICC = 0.82), and total volume (ICC = 0.85). Overall intra-individual variability was low (coefficient of variance = 9%). After defecation the volume of the rectosigmoid decreased by 44% (p = 0.003). The change in rectosigmoid volume was associated with the true fecal volume (p = 0.02).

CONCLUSIONS & INFERENCES: Imaging of segmental colorectal volume, morphology, and fecal accumulation is advantageous to conventional methods in its low variability, high spatial resolution, and its absence of contrast-enhancing agents and irradiation. Hence, the method is suitable for future clinical and interventional studies and for characterization of defecation physiology.

OriginalsprogEngelsk
TidsskriftNeurogastroenterology and Motility
Vol/bind27
Nummer12
Sider (fra-til)1755-63
Antal sider9
ISSN1350-1925
DOI
StatusUdgivet - dec. 2015

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