Asbjørn Mohr Drewes

Patients with Barrett's esophagus are hypersensitive to acid but hyposensitive to other stimuli compared with healthy controls

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DOI

  • C. Lottrup, Aalborg Univ Hosp, Aalborg University, Dept Gastroenterol & Hepatol, Mech Sense, North Denmark Reg Hosp, Dept Med
  • ,
  • A. L. Krarup, Aalborg Univ Hosp, Aalborg University, Dept Gastroenterol & Hepatol, Mech Sense, North Denmark Reg Hosp, Dept Med
  • ,
  • H. Gregersen, Chinese Univ Hong Kong, Prince of Wales Hospital, Chinese University of Hong Kong, Prince Wales Hosp, GIOME, Dept Surg
  • ,
  • P. Ejstrud, Aalborg Univ Hosp, Aalborg University, Dept Gastrointestinal Surg
  • ,
  • A. M. Drewes

Background: Esophageal hyposensitivity has been observed in Barrett's esophagus and may contribute to its pathophysiology. However, studies are few, in particular those assessing different sensory modalities. We aimed to compare esophageal sensitivity to multimodal stimulation in patients with Barrett's esophagus and in healthy controls.

Methods: Twenty-three patients with Barrett's esophagus and 12 healthy controls were examined. A multimodal probe was placed in the lower esophagus. Mechanical, thermal, and electrical stimulation was applied followed by an acid perfusion test with 0.1 N hydrochloric acid.

Key Results: Compared with controls, patients were hyposensitive to mechanical distension, heat, and electrical stimulation (all P

Conclusions & Inferences: Patients with Barrett's esophagus exhibited acid hypersensitivity but hyposensitivity to other stimuli. Lower mucosal baseline impedance, a likely surrogate marker for impaired mucosal integrity, may explain the selective hypersensitivity to acid. On the other hand, the concurrent hyposensitivity may theoretically be explained by changes in central pain modulation. Patients with Barrett's esophagus seem to compose symptomatic and asymptomatic subgroups, showing different esophageal sensory profiles.

OriginalsprogEngelsk
Artikelnummer12992
TidsskriftNeurogastroenterology and Motility
Vol/bind29
Nummer4
Antal sider12
ISSN1350-1925
DOI
StatusUdgivet - apr. 2017

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