Institut for Biomedicin

Asbjørn Mohr Drewes

Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Pathology of skeletal muscle in fibromyalgia : a histo-immuno-chemical and ultrastructural study. / Drewes, A M; Andreasen, A; Schrøder, H D; Høgsaa, B; Jennum, Poul.

I: British Journal of Rheumatology, Bind 32, Nr. 6, 1993, s. 479-83.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Drewes, AM, Andreasen, A, Schrøder, HD, Høgsaa, B & Jennum, P 1993, 'Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study', British Journal of Rheumatology, bind 32, nr. 6, s. 479-83.

APA

Drewes, A. M., Andreasen, A., Schrøder, H. D., Høgsaa, B., & Jennum, P. (1993). Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. British Journal of Rheumatology, 32(6), 479-83.

CBE

Drewes AM, Andreasen A, Schrøder HD, Høgsaa B, Jennum P. 1993. Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. British Journal of Rheumatology. 32(6):479-83.

MLA

Vancouver

Drewes AM, Andreasen A, Schrøder HD, Høgsaa B, Jennum P. Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. British Journal of Rheumatology. 1993;32(6):479-83.

Author

Drewes, A M ; Andreasen, A ; Schrøder, H D ; Høgsaa, B ; Jennum, Poul. / Pathology of skeletal muscle in fibromyalgia : a histo-immuno-chemical and ultrastructural study. I: British Journal of Rheumatology. 1993 ; Bind 32, Nr. 6. s. 479-83.

Bibtex

@article{64a124ca7afd4aed9c74d2e2de78ec7e,
title = "Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study",
abstract = "The value of muscle biopsy in fibromyalgia is still questioned. In this study we obtained 50 quadriceps biopsies from 20 patients and compared them blindly to 10 biopsies from five normal controls. Using light microscopy, histochemical and immunoenzymatic methods we found no definite evidence of muscle disease. Nevertheless, we subjected biopsies from nine of the patients and five other controls for further ultrastructural evaluations and demonstrated pathologic findings e.g. empty sleeves of basement membrane, many lipofuschin bodies and other degenerative changes. We conclude that ultrastructural evaluation cannot yet be used for diagnostic purposes, but the negative findings with light microscopy, including histochemical and immunoenzymatic techniques, might be of importance in evaluating difficult cases.",
keywords = "Adult, Biopsy, Female, Fibromyalgia, Humans, Immunohistochemistry, Microscopy, Electron, Middle Aged, Muscles",
author = "Drewes, {A M} and A Andreasen and Schr{\o}der, {H D} and B H{\o}gsaa and Poul Jennum",
year = "1993",
language = "English",
volume = "32",
pages = "479--83",
journal = "British Journal of Rheumatology",
issn = "0263-7103",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Pathology of skeletal muscle in fibromyalgia

T2 - a histo-immuno-chemical and ultrastructural study

AU - Drewes, A M

AU - Andreasen, A

AU - Schrøder, H D

AU - Høgsaa, B

AU - Jennum, Poul

PY - 1993

Y1 - 1993

N2 - The value of muscle biopsy in fibromyalgia is still questioned. In this study we obtained 50 quadriceps biopsies from 20 patients and compared them blindly to 10 biopsies from five normal controls. Using light microscopy, histochemical and immunoenzymatic methods we found no definite evidence of muscle disease. Nevertheless, we subjected biopsies from nine of the patients and five other controls for further ultrastructural evaluations and demonstrated pathologic findings e.g. empty sleeves of basement membrane, many lipofuschin bodies and other degenerative changes. We conclude that ultrastructural evaluation cannot yet be used for diagnostic purposes, but the negative findings with light microscopy, including histochemical and immunoenzymatic techniques, might be of importance in evaluating difficult cases.

AB - The value of muscle biopsy in fibromyalgia is still questioned. In this study we obtained 50 quadriceps biopsies from 20 patients and compared them blindly to 10 biopsies from five normal controls. Using light microscopy, histochemical and immunoenzymatic methods we found no definite evidence of muscle disease. Nevertheless, we subjected biopsies from nine of the patients and five other controls for further ultrastructural evaluations and demonstrated pathologic findings e.g. empty sleeves of basement membrane, many lipofuschin bodies and other degenerative changes. We conclude that ultrastructural evaluation cannot yet be used for diagnostic purposes, but the negative findings with light microscopy, including histochemical and immunoenzymatic techniques, might be of importance in evaluating difficult cases.

KW - Adult

KW - Biopsy

KW - Female

KW - Fibromyalgia

KW - Humans

KW - Immunohistochemistry

KW - Microscopy, Electron

KW - Middle Aged

KW - Muscles

M3 - Journal article

C2 - 8508284

VL - 32

SP - 479

EP - 483

JO - British Journal of Rheumatology

JF - British Journal of Rheumatology

SN - 0263-7103

IS - 6

ER -