Institut for Biomedicin

Asbjørn Mohr Drewes

Muskelbiopsier hos patienter med fibromyalgi. En undersøgelse baseret på lys- og elektronmikroskopi

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • A M Drewes
  • A Andreasen, Danmark
  • H D Schrøder, Danmark
  • B U Høgsaa
  • ,
  • Poul Jennum, Institut for Neuro- og Sansefag, Danmark
The value of muscle biopsy in fibromyalgia is still questioned. In this study we obtained 49 quadriceps biopsies from 20 patients and compared them blindly to 15 biopsies from five normal controls. Using light microscopy, histochemical and immunoenzymatic methods we found no definite evidence of muscle disease. Nevertheless, we subjected biopsies from nine of the patients and five other controls for further ultrastructural evaluations and demonstrated pathologic findings e.g. empty sleeves of basement membrane, many lipofuscin bodies and other degenerative changes. We conclude that ultrastructural evaluation cannot yet be used for diagnostic purposes, but the negative findings at light microscopy, including histochemical and immunoenzymatic techniques, might be of importance in evaluating difficult cases.
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind156
Nummer46
Sider (fra-til)6844-7
Antal sider4
ISSN0041-5782
StatusUdgivet - 1994

    Forskningsområder

  • Adult, Biopsy, Double-Blind Method, Female, Fibromyalgia, Histocytochemistry, Humans, Microscopy, Electron, Middle Aged, Muscle, Skeletal

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