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Asbjørn Mohr Drewes

Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. / Brock, C; Nissen, T D; Gravesen, F H; Frøkjær, J.B.; Omar, H; Gale, J; Gregersen, H; Svendsen, O; Drewes, A M.

I: Neurogastroenterology and Motility, Bind 20, Nr. 8, 2008, s. 908-18.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Brock, C, Nissen, TD, Gravesen, FH, Frøkjær, JB, Omar, H, Gale, J, Gregersen, H, Svendsen, O & Drewes, AM 2008, 'Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method', Neurogastroenterology and Motility, bind 20, nr. 8, s. 908-18. https://doi.org/10.1111/j.1365-2982.2008.01126.x

APA

Brock, C., Nissen, T. D., Gravesen, F. H., Frøkjær, J. B., Omar, H., Gale, J., Gregersen, H., Svendsen, O., & Drewes, A. M. (2008). Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. Neurogastroenterology and Motility, 20(8), 908-18. https://doi.org/10.1111/j.1365-2982.2008.01126.x

CBE

Brock C, Nissen TD, Gravesen FH, Frøkjær JB, Omar H, Gale J, Gregersen H, Svendsen O, Drewes AM. 2008. Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. Neurogastroenterology and Motility. 20(8):908-18. https://doi.org/10.1111/j.1365-2982.2008.01126.x

MLA

Vancouver

Brock C, Nissen TD, Gravesen FH, Frøkjær JB, Omar H, Gale J o.a. Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. Neurogastroenterology and Motility. 2008;20(8):908-18. https://doi.org/10.1111/j.1365-2982.2008.01126.x

Author

Brock, C ; Nissen, T D ; Gravesen, F H ; Frøkjær, J.B. ; Omar, H ; Gale, J ; Gregersen, H ; Svendsen, O ; Drewes, A M. / Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. I: Neurogastroenterology and Motility. 2008 ; Bind 20, Nr. 8. s. 908-18.

Bibtex

@article{6fe0b0c0dd6311dd9b3b000ea68e967b,
title = "Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method",
abstract = "Evaluation of rectal and rectosigmoid sensation is important in basic, clinical and pharmacological studies. New methods to evoke and assess multimodal (electrical, thermal and mechanical) experimental pain of the upper gut activate distinct pathways and mimics clinical pain. The aims of the current study were to characterize the sensory response and reproducibility to multimodal stimulation of rectum and the rectosigmoid. A multimodal rectal probe was developed. Mucosal electrostimulation was delivered at the recto-sigmoid junction. In Rectum, impedance planimetry was used for measurement of cross-sectional area (CSA) during distension. Circulation of water within the bag at either 4 or 60 degrees C was applied for thermal stimulation. The method was tested in 12 healthy volunteers (six men mean age 32 years) on two subsequent days. Mechanical and sensory responses and referred pain areas were assessed. Stimulation with electrical, thermal and mechanical modalities resulted in different sensory perceptions. The relationship between stimulus intensity and sensory response was linear for all modalities. Sensory response to different modalities did not differ between investigation days (all P-values > 0.1). Approximately 75% of subjects felt referred pain in distinct skin locations. Between-days reproducibility was good for all modalities [intra-class correlation (ICC) > or = 0.6]. At sensory threshold, CSA showed best reproducibility (ICC > or = 0.9). At pain detection threshold stretch ratio, CSA and electrostimulation showed best reproducibility (ICC = 1.0; 0.9; 0.9). The present model was easily implemented, robust and showed good reproducibility. It can be used to study pathophysiology or pharmacological interventions in healthy controls and in patients with diseases involving the distal hindgut.",
keywords = "Abdominal Pain, Adult, Butylscopolammonium Bromide, Colon, Sigmoid, Electric Stimulation, Humans, Male, Pain Measurement, Pain Threshold, Pain, Referred, Parasympatholytics, Rectum, Reproducibility of Results, Stress, Mechanical, Temperature",
author = "C Brock and Nissen, {T D} and Gravesen, {F H} and J.B. Fr{\o}kj{\ae}r and H Omar and J Gale and H Gregersen and O Svendsen and Drewes, {A M}",
year = "2008",
doi = "10.1111/j.1365-2982.2008.01126.x",
language = "English",
volume = "20",
pages = "908--18",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method

AU - Brock, C

AU - Nissen, T D

AU - Gravesen, F H

AU - Frøkjær, J.B.

AU - Omar, H

AU - Gale, J

AU - Gregersen, H

AU - Svendsen, O

AU - Drewes, A M

PY - 2008

Y1 - 2008

N2 - Evaluation of rectal and rectosigmoid sensation is important in basic, clinical and pharmacological studies. New methods to evoke and assess multimodal (electrical, thermal and mechanical) experimental pain of the upper gut activate distinct pathways and mimics clinical pain. The aims of the current study were to characterize the sensory response and reproducibility to multimodal stimulation of rectum and the rectosigmoid. A multimodal rectal probe was developed. Mucosal electrostimulation was delivered at the recto-sigmoid junction. In Rectum, impedance planimetry was used for measurement of cross-sectional area (CSA) during distension. Circulation of water within the bag at either 4 or 60 degrees C was applied for thermal stimulation. The method was tested in 12 healthy volunteers (six men mean age 32 years) on two subsequent days. Mechanical and sensory responses and referred pain areas were assessed. Stimulation with electrical, thermal and mechanical modalities resulted in different sensory perceptions. The relationship between stimulus intensity and sensory response was linear for all modalities. Sensory response to different modalities did not differ between investigation days (all P-values > 0.1). Approximately 75% of subjects felt referred pain in distinct skin locations. Between-days reproducibility was good for all modalities [intra-class correlation (ICC) > or = 0.6]. At sensory threshold, CSA showed best reproducibility (ICC > or = 0.9). At pain detection threshold stretch ratio, CSA and electrostimulation showed best reproducibility (ICC = 1.0; 0.9; 0.9). The present model was easily implemented, robust and showed good reproducibility. It can be used to study pathophysiology or pharmacological interventions in healthy controls and in patients with diseases involving the distal hindgut.

AB - Evaluation of rectal and rectosigmoid sensation is important in basic, clinical and pharmacological studies. New methods to evoke and assess multimodal (electrical, thermal and mechanical) experimental pain of the upper gut activate distinct pathways and mimics clinical pain. The aims of the current study were to characterize the sensory response and reproducibility to multimodal stimulation of rectum and the rectosigmoid. A multimodal rectal probe was developed. Mucosal electrostimulation was delivered at the recto-sigmoid junction. In Rectum, impedance planimetry was used for measurement of cross-sectional area (CSA) during distension. Circulation of water within the bag at either 4 or 60 degrees C was applied for thermal stimulation. The method was tested in 12 healthy volunteers (six men mean age 32 years) on two subsequent days. Mechanical and sensory responses and referred pain areas were assessed. Stimulation with electrical, thermal and mechanical modalities resulted in different sensory perceptions. The relationship between stimulus intensity and sensory response was linear for all modalities. Sensory response to different modalities did not differ between investigation days (all P-values > 0.1). Approximately 75% of subjects felt referred pain in distinct skin locations. Between-days reproducibility was good for all modalities [intra-class correlation (ICC) > or = 0.6]. At sensory threshold, CSA showed best reproducibility (ICC > or = 0.9). At pain detection threshold stretch ratio, CSA and electrostimulation showed best reproducibility (ICC = 1.0; 0.9; 0.9). The present model was easily implemented, robust and showed good reproducibility. It can be used to study pathophysiology or pharmacological interventions in healthy controls and in patients with diseases involving the distal hindgut.

KW - Abdominal Pain

KW - Adult

KW - Butylscopolammonium Bromide

KW - Colon, Sigmoid

KW - Electric Stimulation

KW - Humans

KW - Male

KW - Pain Measurement

KW - Pain Threshold

KW - Pain, Referred

KW - Parasympatholytics

KW - Rectum

KW - Reproducibility of Results

KW - Stress, Mechanical

KW - Temperature

U2 - 10.1111/j.1365-2982.2008.01126.x

DO - 10.1111/j.1365-2982.2008.01126.x

M3 - Journal article

C2 - 18482255

VL - 20

SP - 908

EP - 918

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 8

ER -