Asbjørn Mohr Drewes

Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. / Muthulingam, J; Haas, S; Hansen, T M; Laurberg, S; Lundby, L; Jørgensen, H S; Drewes, A M; Krogh, K; Frøkjaer, J B.

I: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Bind 30, Nr. 1, e13164, 01.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Muthulingam, J, Haas, S, Hansen, TM, Laurberg, S, Lundby, L, Jørgensen, HS, Drewes, AM, Krogh, K & Frøkjaer, JB 2018, 'Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, bind 30, nr. 1, e13164. https://doi.org/10.1111/nmo.13164

APA

Muthulingam, J., Haas, S., Hansen, T. M., Laurberg, S., Lundby, L., Jørgensen, H. S., Drewes, A. M., Krogh, K., & Frøkjaer, J. B. (2018). Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30(1), [e13164]. https://doi.org/10.1111/nmo.13164

CBE

Muthulingam J, Haas S, Hansen TM, Laurberg S, Lundby L, Jørgensen HS, Drewes AM, Krogh K, Frøkjaer JB. 2018. Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 30(1):Article e13164. https://doi.org/10.1111/nmo.13164

MLA

Muthulingam, J o.a.. "Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence". Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2018. 30(1). https://doi.org/10.1111/nmo.13164

Vancouver

Muthulingam J, Haas S, Hansen TM, Laurberg S, Lundby L, Jørgensen HS o.a. Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2018 jan;30(1). e13164. https://doi.org/10.1111/nmo.13164

Author

Muthulingam, J ; Haas, S ; Hansen, T M ; Laurberg, S ; Lundby, L ; Jørgensen, H S ; Drewes, A M ; Krogh, K ; Frøkjaer, J B. / Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. I: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2018 ; Bind 30, Nr. 1.

Bibtex

@article{e77a6744415c49dda3aad88b42fb715f,
title = "Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence",
abstract = "BACKGROUND: Abnormal central nervous system processing of visceral sensation may be a part of the pathogenesis behind idiopathic fecal incontinence (IFI). Our aim was to characterize brain differences in patients with IFI and healthy controls by means of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).METHODS: In 21 female patients with IFI and 15 female healthy controls, whole-brain structural differences in gray matter volume (GMV), cortical thickness, and white matter tracts fractional anisotropy (FA) were quantified. For this purpose, we used voxel-based morphometry, surface based morphometry and tract-based spatial statistic, respectively. Furthermore, associations between structural brain characteristics and latencies of rectal sensory evoked electroencephalography potentials were determined.KEY RESULTS: Compared to healthy controls, IFI patients had significantly reduced FA values, reflecting reduced white matter tract integrity, in the left hemisphere superior longitudinal fasciculus (SLF), posterior thalamic radiation, and middle frontal gyrus (MFG), all P<.05. No differences were observed in GMV or in cortical thickness. The reduced FA values in the SLF and MFG were correlated with prolonged latencies of cortical potentials evoked by rectal stimuli (all P<.05).CONCLUSIONS & INFERENCES: This explorative study suggests that IFI patients have no macrostructural brain changes, but exhibit microstructural changes in white matter tracts relevant for sensory processing. The clinical relevance of this finding is supported by its correlations with prolonged latencies of cortical potentials evoked by rectal stimulation. This supports the theories of central nervous system changes as part of the pathogenesis in IFI patients.",
keywords = "Journal Article",
author = "J Muthulingam and S Haas and Hansen, {T M} and S Laurberg and L Lundby and J{\o}rgensen, {H S} and Drewes, {A M} and K Krogh and Fr{\o}kjaer, {J B}",
note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",
year = "2018",
month = jan,
doi = "10.1111/nmo.13164",
language = "English",
volume = "30",
journal = "Neurogastroenterology and Motility Online",
issn = "1365-2982",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence

AU - Muthulingam, J

AU - Haas, S

AU - Hansen, T M

AU - Laurberg, S

AU - Lundby, L

AU - Jørgensen, H S

AU - Drewes, A M

AU - Krogh, K

AU - Frøkjaer, J B

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Abnormal central nervous system processing of visceral sensation may be a part of the pathogenesis behind idiopathic fecal incontinence (IFI). Our aim was to characterize brain differences in patients with IFI and healthy controls by means of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).METHODS: In 21 female patients with IFI and 15 female healthy controls, whole-brain structural differences in gray matter volume (GMV), cortical thickness, and white matter tracts fractional anisotropy (FA) were quantified. For this purpose, we used voxel-based morphometry, surface based morphometry and tract-based spatial statistic, respectively. Furthermore, associations between structural brain characteristics and latencies of rectal sensory evoked electroencephalography potentials were determined.KEY RESULTS: Compared to healthy controls, IFI patients had significantly reduced FA values, reflecting reduced white matter tract integrity, in the left hemisphere superior longitudinal fasciculus (SLF), posterior thalamic radiation, and middle frontal gyrus (MFG), all P<.05. No differences were observed in GMV or in cortical thickness. The reduced FA values in the SLF and MFG were correlated with prolonged latencies of cortical potentials evoked by rectal stimuli (all P<.05).CONCLUSIONS & INFERENCES: This explorative study suggests that IFI patients have no macrostructural brain changes, but exhibit microstructural changes in white matter tracts relevant for sensory processing. The clinical relevance of this finding is supported by its correlations with prolonged latencies of cortical potentials evoked by rectal stimulation. This supports the theories of central nervous system changes as part of the pathogenesis in IFI patients.

AB - BACKGROUND: Abnormal central nervous system processing of visceral sensation may be a part of the pathogenesis behind idiopathic fecal incontinence (IFI). Our aim was to characterize brain differences in patients with IFI and healthy controls by means of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).METHODS: In 21 female patients with IFI and 15 female healthy controls, whole-brain structural differences in gray matter volume (GMV), cortical thickness, and white matter tracts fractional anisotropy (FA) were quantified. For this purpose, we used voxel-based morphometry, surface based morphometry and tract-based spatial statistic, respectively. Furthermore, associations between structural brain characteristics and latencies of rectal sensory evoked electroencephalography potentials were determined.KEY RESULTS: Compared to healthy controls, IFI patients had significantly reduced FA values, reflecting reduced white matter tract integrity, in the left hemisphere superior longitudinal fasciculus (SLF), posterior thalamic radiation, and middle frontal gyrus (MFG), all P<.05. No differences were observed in GMV or in cortical thickness. The reduced FA values in the SLF and MFG were correlated with prolonged latencies of cortical potentials evoked by rectal stimuli (all P<.05).CONCLUSIONS & INFERENCES: This explorative study suggests that IFI patients have no macrostructural brain changes, but exhibit microstructural changes in white matter tracts relevant for sensory processing. The clinical relevance of this finding is supported by its correlations with prolonged latencies of cortical potentials evoked by rectal stimulation. This supports the theories of central nervous system changes as part of the pathogenesis in IFI patients.

KW - Journal Article

U2 - 10.1111/nmo.13164

DO - 10.1111/nmo.13164

M3 - Journal article

C2 - 28730720

VL - 30

JO - Neurogastroenterology and Motility Online

JF - Neurogastroenterology and Motility Online

SN - 1365-2982

IS - 1

M1 - e13164

ER -