Aarhus University Seal / Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » Asbjørn Mohr Drewes » Publikationer » Electrical low-frequency stimulation induces central neur...

Om AU

Asbjørn Mohr Drewes

Electrical low-frequency stimulation induces central neuroplastic changes of pain processing in man

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Kerstin Jung, Center for Sanse-Motorisk Interaktion, Danmark
  • D Lelic
  • Silke Rottmann, Institut for Medicin og Sundhedsteknologi, Danmark
  • A M Drewes
  • Laura Petrini, Institut for Kommunikation, Danmark
  • Jens Ellrich, Center for Sanse-Motorisk Interaktion, Danmark
Electrical low-frequency stimulation (LFS) inhibits pain perception and nociceptive processing as shown by psychophysical and electrophysiological means (long-term depression, LTD). Information regarding central mechanisms involved in LTD induction and maintenance are still missing. This study hypothesizes that electrical LFS induces changes in activation pattern of pain-related brain areas. Thirty-two electrophysiological and psychophysical experiments were performed in 16 healthy volunteers. Painful electrical test stimulation (0.125 Hz, 60 pulses) and conditioning LFS (1 Hz, 1200 pulses) were applied by a concentric electrode to the right hand. Test stimulation series were performed before (Pre) and after LFS (Post) or no stimulation period (Control). Volunteers rated pain perception according to a verbal rating scale (0-100). Somatosensory evoked cortical potentials were recorded with 64-channel electroencephalography. Individual dipole source modeling using CURRY software (Compumedics, Hamburg, Germany) yielded information about dipole location and strength. The strongest decrease in LFS-induced pain perception was shown after LFS (p 
OriginalsprogEngelsk
TidsskriftEuropean Journal of Pain
Vol/bind16
Nummer4
Sider (fra-til)509-21
Antal sider13
ISSN1090-3801
DOI
StatusUdgivet - 2012

Se relationer på Aarhus Universitet Citationsformater

ID: 44754689