Asbjørn Mohr Drewes

Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. / Beyer, Georg; Mahajan, Ujjwal M.; Budde, Christoph; Bulla, Thomas J.; Kohlmann, Thomas; Kuhlmann, Louise; Schuette, Kerstin; Aghdassi, Ali A.; Weber, Eckhard; Weiss, F. Ulrich; Drewes, Asbjorn M.; Olesen, Soren S.; Lerch, Markus M.; Mayerle, Julia.

I: Gastroenterology, Bind 153, Nr. 6, 12.2017, s. 1544-+.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Beyer, G, Mahajan, UM, Budde, C, Bulla, TJ, Kohlmann, T, Kuhlmann, L, Schuette, K, Aghdassi, AA, Weber, E, Weiss, FU, Drewes, AM, Olesen, SS, Lerch, MM & Mayerle, J 2017, 'Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts', Gastroenterology, bind 153, nr. 6, s. 1544-+. https://doi.org/10.1053/j.gastro.2017.08.073

APA

Beyer, G., Mahajan, U. M., Budde, C., Bulla, T. J., Kohlmann, T., Kuhlmann, L., ... Mayerle, J. (2017). Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. Gastroenterology, 153(6), 1544-+. https://doi.org/10.1053/j.gastro.2017.08.073

CBE

Beyer G, Mahajan UM, Budde C, Bulla TJ, Kohlmann T, Kuhlmann L, Schuette K, Aghdassi AA, Weber E, Weiss FU, Drewes AM, Olesen SS, Lerch MM, Mayerle J. 2017. Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. Gastroenterology. 153(6):1544-+. https://doi.org/10.1053/j.gastro.2017.08.073

MLA

Vancouver

Beyer G, Mahajan UM, Budde C, Bulla TJ, Kohlmann T, Kuhlmann L o.a. Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. Gastroenterology. 2017 dec;153(6):1544-+. https://doi.org/10.1053/j.gastro.2017.08.073

Author

Beyer, Georg ; Mahajan, Ujjwal M. ; Budde, Christoph ; Bulla, Thomas J. ; Kohlmann, Thomas ; Kuhlmann, Louise ; Schuette, Kerstin ; Aghdassi, Ali A. ; Weber, Eckhard ; Weiss, F. Ulrich ; Drewes, Asbjorn M. ; Olesen, Soren S. ; Lerch, Markus M. ; Mayerle, Julia. / Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. I: Gastroenterology. 2017 ; Bind 153, Nr. 6. s. 1544-+.

Bibtex

@article{e461b8cabaef486a9d6315af8d67cf94,
title = "Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts",
abstract = "BACKGROUND & AIMS: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes. METHODS: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were used to develop a 3-stage chronic pancreatitis prognosis score (COPPS). The predictive strength was validated in 129 independent subjects identified from 2 prospective databases. RESULTS: The mean number of hospital admissions was 1.9 (95{\%} confidence interval [CI], 1.39-2.44) and 15.2 for hospital days (95{\%} CI, 10.76-19.71) for the development cohort and 10.9 for the validation cohort (95{\%} CI, 7.54-14.30) (P = .08). Based on bivariate correlations, pain (numeric rating scale), level of glycated hemoglobin A1c, level of C-reactive protein, body mass index, and platelet count were used to develop the COPPS system. The patients' median COPPS was 8.9 points (range, 5-14). The system accurately discriminated stages of disease severity (low to high): A (5-6 points), B (7-9), and C (10-15). In Pearson correlation analysis of the development cohort, the COPPS correlated with hospital admissions (0.39; P <.01) and number of hospital days (0.33; P <.01). The correlation was validated in the validation set (Pearson correlation values of 0.36 and 0.44; P <.01). COPPS did not correlate with results from the Cambridge classification system. CONCLUSIONS: We developed and validated an easy to use dynamic multivariate scoring system, similar to the Child-Pugh-Score for liver cirrhosis. The COPPS allows objective monitoring of patients with chronic pancreatitis, determining risk for readmission to hospital and potential length of hospital stay.",
keywords = "C-reactive Protein, BMI, Pancreas, Clinical Scoring System, Child-Pugh-Turcotte Score, M-ANNHEIM CLASSIFICATION, LONG-TERM, SYSTEM, DIAGNOSIS, EXOCRINE, ETIOLOGY, PAIN, PANCREATOGRAPHY, DEFINITION, MANAGEMENT",
author = "Georg Beyer and Mahajan, {Ujjwal M.} and Christoph Budde and Bulla, {Thomas J.} and Thomas Kohlmann and Louise Kuhlmann and Kerstin Schuette and Aghdassi, {Ali A.} and Eckhard Weber and Weiss, {F. Ulrich} and Drewes, {Asbjorn M.} and Olesen, {Soren S.} and Lerch, {Markus M.} and Julia Mayerle",
year = "2017",
month = "12",
doi = "10.1053/j.gastro.2017.08.073",
language = "English",
volume = "153",
pages = "1544--+",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts

AU - Beyer, Georg

AU - Mahajan, Ujjwal M.

AU - Budde, Christoph

AU - Bulla, Thomas J.

AU - Kohlmann, Thomas

AU - Kuhlmann, Louise

AU - Schuette, Kerstin

AU - Aghdassi, Ali A.

AU - Weber, Eckhard

AU - Weiss, F. Ulrich

AU - Drewes, Asbjorn M.

AU - Olesen, Soren S.

AU - Lerch, Markus M.

AU - Mayerle, Julia

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND & AIMS: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes. METHODS: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were used to develop a 3-stage chronic pancreatitis prognosis score (COPPS). The predictive strength was validated in 129 independent subjects identified from 2 prospective databases. RESULTS: The mean number of hospital admissions was 1.9 (95% confidence interval [CI], 1.39-2.44) and 15.2 for hospital days (95% CI, 10.76-19.71) for the development cohort and 10.9 for the validation cohort (95% CI, 7.54-14.30) (P = .08). Based on bivariate correlations, pain (numeric rating scale), level of glycated hemoglobin A1c, level of C-reactive protein, body mass index, and platelet count were used to develop the COPPS system. The patients' median COPPS was 8.9 points (range, 5-14). The system accurately discriminated stages of disease severity (low to high): A (5-6 points), B (7-9), and C (10-15). In Pearson correlation analysis of the development cohort, the COPPS correlated with hospital admissions (0.39; P <.01) and number of hospital days (0.33; P <.01). The correlation was validated in the validation set (Pearson correlation values of 0.36 and 0.44; P <.01). COPPS did not correlate with results from the Cambridge classification system. CONCLUSIONS: We developed and validated an easy to use dynamic multivariate scoring system, similar to the Child-Pugh-Score for liver cirrhosis. The COPPS allows objective monitoring of patients with chronic pancreatitis, determining risk for readmission to hospital and potential length of hospital stay.

AB - BACKGROUND & AIMS: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes. METHODS: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were used to develop a 3-stage chronic pancreatitis prognosis score (COPPS). The predictive strength was validated in 129 independent subjects identified from 2 prospective databases. RESULTS: The mean number of hospital admissions was 1.9 (95% confidence interval [CI], 1.39-2.44) and 15.2 for hospital days (95% CI, 10.76-19.71) for the development cohort and 10.9 for the validation cohort (95% CI, 7.54-14.30) (P = .08). Based on bivariate correlations, pain (numeric rating scale), level of glycated hemoglobin A1c, level of C-reactive protein, body mass index, and platelet count were used to develop the COPPS system. The patients' median COPPS was 8.9 points (range, 5-14). The system accurately discriminated stages of disease severity (low to high): A (5-6 points), B (7-9), and C (10-15). In Pearson correlation analysis of the development cohort, the COPPS correlated with hospital admissions (0.39; P <.01) and number of hospital days (0.33; P <.01). The correlation was validated in the validation set (Pearson correlation values of 0.36 and 0.44; P <.01). COPPS did not correlate with results from the Cambridge classification system. CONCLUSIONS: We developed and validated an easy to use dynamic multivariate scoring system, similar to the Child-Pugh-Score for liver cirrhosis. The COPPS allows objective monitoring of patients with chronic pancreatitis, determining risk for readmission to hospital and potential length of hospital stay.

KW - C-reactive Protein

KW - BMI

KW - Pancreas

KW - Clinical Scoring System

KW - Child-Pugh-Turcotte Score

KW - M-ANNHEIM CLASSIFICATION

KW - LONG-TERM

KW - SYSTEM

KW - DIAGNOSIS

KW - EXOCRINE

KW - ETIOLOGY

KW - PAIN

KW - PANCREATOGRAPHY

KW - DEFINITION

KW - MANAGEMENT

U2 - 10.1053/j.gastro.2017.08.073

DO - 10.1053/j.gastro.2017.08.073

M3 - Journal article

C2 - 28918191

VL - 153

SP - 1544-+

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -