Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

Deterioration of muscle function in the human esophagus with age

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Deterioration of muscle function in the human esophagus with age. / Gregersen, Hans; Pedersen, Jan; Drewes, Asbjørn Mohr.

I: Digestive Diseases and Sciences, Bind 53, Nr. 12, 2008, s. 3065-70.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Gregersen, H, Pedersen, J & Drewes, AM 2008, 'Deterioration of muscle function in the human esophagus with age', Digestive Diseases and Sciences, bind 53, nr. 12, s. 3065-70. https://doi.org/10.1007/s10620-008-0278-y

APA

Gregersen, H., Pedersen, J., & Drewes, A. M. (2008). Deterioration of muscle function in the human esophagus with age. Digestive Diseases and Sciences, 53(12), 3065-70. https://doi.org/10.1007/s10620-008-0278-y

CBE

Gregersen H, Pedersen J, Drewes AM. 2008. Deterioration of muscle function in the human esophagus with age. Digestive Diseases and Sciences. 53(12):3065-70. https://doi.org/10.1007/s10620-008-0278-y

MLA

Gregersen, Hans, Jan Pedersen, og Asbjørn Mohr Drewes. "Deterioration of muscle function in the human esophagus with age". Digestive Diseases and Sciences. 2008, 53(12). 3065-70. https://doi.org/10.1007/s10620-008-0278-y

Vancouver

Gregersen H, Pedersen J, Drewes AM. Deterioration of muscle function in the human esophagus with age. Digestive Diseases and Sciences. 2008;53(12):3065-70. https://doi.org/10.1007/s10620-008-0278-y

Author

Gregersen, Hans ; Pedersen, Jan ; Drewes, Asbjørn Mohr. / Deterioration of muscle function in the human esophagus with age. I: Digestive Diseases and Sciences. 2008 ; Bind 53, Nr. 12. s. 3065-70.

Bibtex

@article{7ad7375004b511de8317000ea68e967b,
title = "Deterioration of muscle function in the human esophagus with age",
abstract = "Most studies on the effect of aging on esophageal motor function have shown that peristaltic function deteriorates with age. Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years. In this study, we did a manometric swallow analysis and used the distension method to study esophageal properties and function during aging. An impedance planimetric probe with a bag for distension was placed in the distal esophagus of 25 healthy volunteers with a median age of 35 (range 23-86) years. Distensions were done at an infusion rate of 25 ml min(-1) with and without relaxation of neuromuscular activity with butylscopolamine. The infusion was reversed when moderate pain was experienced by the subjects. Swallow-induced contraction amplitudes decreased as function of age for persons older than 40 years (P < 0.05). The total and passive tension showed an exponential increase as function of the change in radius, whereas the active tension increased until it reached a local maximum point. The maximum active tension deteriorated as a function of age after the age of 40 years (P < 0.05). Furthermore, esophagus became stiffer with age. In conclusion, age-related changes of increased stiffness and reduced primary and secondary peristalsis were found in the human esophagus with a deterioration of esophageal function after the age of 40 years. Such changes may contribute to the high prevalence of reflux disease in elderly.",
keywords = "Adult, Aged, Aged, 80 and over, Aging, Butylscopolammonium Bromide, Deglutition, Esophageal Motility Disorders, Esophagus, Female, Humans, Male, Manometry, Middle Aged, Muscle Contraction, Muscle, Smooth, Parasympatholytics, Peristalsis",
author = "Hans Gregersen and Jan Pedersen and Drewes, {Asbj{\o}rn Mohr}",
year = "2008",
doi = "10.1007/s10620-008-0278-y",
language = "English",
volume = "53",
pages = "3065--70",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York LLC",
number = "12",

}

RIS

TY - JOUR

T1 - Deterioration of muscle function in the human esophagus with age

AU - Gregersen, Hans

AU - Pedersen, Jan

AU - Drewes, Asbjørn Mohr

PY - 2008

Y1 - 2008

N2 - Most studies on the effect of aging on esophageal motor function have shown that peristaltic function deteriorates with age. Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years. In this study, we did a manometric swallow analysis and used the distension method to study esophageal properties and function during aging. An impedance planimetric probe with a bag for distension was placed in the distal esophagus of 25 healthy volunteers with a median age of 35 (range 23-86) years. Distensions were done at an infusion rate of 25 ml min(-1) with and without relaxation of neuromuscular activity with butylscopolamine. The infusion was reversed when moderate pain was experienced by the subjects. Swallow-induced contraction amplitudes decreased as function of age for persons older than 40 years (P < 0.05). The total and passive tension showed an exponential increase as function of the change in radius, whereas the active tension increased until it reached a local maximum point. The maximum active tension deteriorated as a function of age after the age of 40 years (P < 0.05). Furthermore, esophagus became stiffer with age. In conclusion, age-related changes of increased stiffness and reduced primary and secondary peristalsis were found in the human esophagus with a deterioration of esophageal function after the age of 40 years. Such changes may contribute to the high prevalence of reflux disease in elderly.

AB - Most studies on the effect of aging on esophageal motor function have shown that peristaltic function deteriorates with age. Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years. In this study, we did a manometric swallow analysis and used the distension method to study esophageal properties and function during aging. An impedance planimetric probe with a bag for distension was placed in the distal esophagus of 25 healthy volunteers with a median age of 35 (range 23-86) years. Distensions were done at an infusion rate of 25 ml min(-1) with and without relaxation of neuromuscular activity with butylscopolamine. The infusion was reversed when moderate pain was experienced by the subjects. Swallow-induced contraction amplitudes decreased as function of age for persons older than 40 years (P < 0.05). The total and passive tension showed an exponential increase as function of the change in radius, whereas the active tension increased until it reached a local maximum point. The maximum active tension deteriorated as a function of age after the age of 40 years (P < 0.05). Furthermore, esophagus became stiffer with age. In conclusion, age-related changes of increased stiffness and reduced primary and secondary peristalsis were found in the human esophagus with a deterioration of esophageal function after the age of 40 years. Such changes may contribute to the high prevalence of reflux disease in elderly.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Butylscopolammonium Bromide

KW - Deglutition

KW - Esophageal Motility Disorders

KW - Esophagus

KW - Female

KW - Humans

KW - Male

KW - Manometry

KW - Middle Aged

KW - Muscle Contraction

KW - Muscle, Smooth

KW - Parasympatholytics

KW - Peristalsis

U2 - 10.1007/s10620-008-0278-y

DO - 10.1007/s10620-008-0278-y

M3 - Journal article

C2 - 18461452

VL - 53

SP - 3065

EP - 3070

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 12

ER -