Asbjørn Mohr Drewes

Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs

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Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs. / Larsen, Helene Mathilde; Borre, Mette; Christensen, Peter et al.

I: Acta Oncologica, Bind 58, Nr. 5, 05.2019, s. 776-781.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{7227ecb217654bb3bbbb86b5172182a2,
title = "Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs",
abstract = "BACKGROUND: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs.MATERIAL AND METHODS: All patients referred to our department of gastroenterology between May 2016 and June 2018 with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs were prospectively evaluated.RESULTS: In total, 60 patients had been referred. The patients were treated for cancer in the right colon (n = 31), sigmoid colon (n = 1), rectum (n = 14), anal canal (n = 4), cervix uteri (n = 5), corpus uteri (n = 2), ovary (n = 2), and prostate (n = 1). The median time from cancer treatment to referral was 5.5 (range 1-36) years. Symptoms mainly included frequent bowel movements (65%), loose stools (87%), urgency for defecation (57%), and fecal incontinence (50%). A specific cause of bowel dysfunction was found in 48 (80%) of the patients and 21 (35%) had more than one cause of bowel symptoms. Bile acid malabsorption was present in 35 patients and small intestinal bacterial overgrowth was detected in 32. Treatment included bile acid sequestrants (n = 36), antibiotics (n = 33), loperamide (n = 21), and dietary intervention (n = 20). Major improvement in bowel symptoms was reported by 23 (38%) patients, while another 27 (45%) reported some improvement.CONCLUSION: Most patients with chronic bowel symptoms following cancer in the colon or pelvic organs will benefit from expert clinical evaluation and targeted treatment.",
keywords = "BILE-ACID MALABSORPTION, CHRONIC DIARRHEA, DIAGNOSIS, GASTROINTESTINAL SYMPTOMS, GYNECOLOGICAL CANCER, INTESTINAL BACTERIAL OVERGROWTH, MANAGEMENT, PATHOGENESIS, RADIOTHERAPY, RESECTION, Prospective Studies, Colorectal Neoplasms/complications, Humans, Middle Aged, Fecal Incontinence/etiology, Male, Ovarian Neoplasms/complications, Steatorrhea/etiology, Adult, Female, Cholestyramine Resin/therapeutic use, Treatment Outcome, Diarrhea/etiology, Prostatic Neoplasms/complications, Uterine Neoplasms/complications, Gastrointestinal Diseases/diet therapy, Aged, Anti-Bacterial Agents/therapeutic use, Chronic Disease, Bile Acids and Salts/metabolism",
author = "Larsen, {Helene Mathilde} and Mette Borre and Peter Christensen and {Mohr Drewes}, Asbj{\o}rn and S{\o}ren Laurberg and Klaus Krogh and Janne Fassov",
year = "2019",
month = may,
doi = "10.1080/0284186X.2018.1562211",
language = "English",
volume = "58",
pages = "776--781",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Taylor & Francis ",
number = "5",

}

RIS

TY - JOUR

T1 - Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs

AU - Larsen, Helene Mathilde

AU - Borre, Mette

AU - Christensen, Peter

AU - Mohr Drewes, Asbjørn

AU - Laurberg, Søren

AU - Krogh, Klaus

AU - Fassov, Janne

PY - 2019/5

Y1 - 2019/5

N2 - BACKGROUND: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs.MATERIAL AND METHODS: All patients referred to our department of gastroenterology between May 2016 and June 2018 with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs were prospectively evaluated.RESULTS: In total, 60 patients had been referred. The patients were treated for cancer in the right colon (n = 31), sigmoid colon (n = 1), rectum (n = 14), anal canal (n = 4), cervix uteri (n = 5), corpus uteri (n = 2), ovary (n = 2), and prostate (n = 1). The median time from cancer treatment to referral was 5.5 (range 1-36) years. Symptoms mainly included frequent bowel movements (65%), loose stools (87%), urgency for defecation (57%), and fecal incontinence (50%). A specific cause of bowel dysfunction was found in 48 (80%) of the patients and 21 (35%) had more than one cause of bowel symptoms. Bile acid malabsorption was present in 35 patients and small intestinal bacterial overgrowth was detected in 32. Treatment included bile acid sequestrants (n = 36), antibiotics (n = 33), loperamide (n = 21), and dietary intervention (n = 20). Major improvement in bowel symptoms was reported by 23 (38%) patients, while another 27 (45%) reported some improvement.CONCLUSION: Most patients with chronic bowel symptoms following cancer in the colon or pelvic organs will benefit from expert clinical evaluation and targeted treatment.

AB - BACKGROUND: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs.MATERIAL AND METHODS: All patients referred to our department of gastroenterology between May 2016 and June 2018 with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs were prospectively evaluated.RESULTS: In total, 60 patients had been referred. The patients were treated for cancer in the right colon (n = 31), sigmoid colon (n = 1), rectum (n = 14), anal canal (n = 4), cervix uteri (n = 5), corpus uteri (n = 2), ovary (n = 2), and prostate (n = 1). The median time from cancer treatment to referral was 5.5 (range 1-36) years. Symptoms mainly included frequent bowel movements (65%), loose stools (87%), urgency for defecation (57%), and fecal incontinence (50%). A specific cause of bowel dysfunction was found in 48 (80%) of the patients and 21 (35%) had more than one cause of bowel symptoms. Bile acid malabsorption was present in 35 patients and small intestinal bacterial overgrowth was detected in 32. Treatment included bile acid sequestrants (n = 36), antibiotics (n = 33), loperamide (n = 21), and dietary intervention (n = 20). Major improvement in bowel symptoms was reported by 23 (38%) patients, while another 27 (45%) reported some improvement.CONCLUSION: Most patients with chronic bowel symptoms following cancer in the colon or pelvic organs will benefit from expert clinical evaluation and targeted treatment.

KW - BILE-ACID MALABSORPTION

KW - CHRONIC DIARRHEA

KW - DIAGNOSIS

KW - GASTROINTESTINAL SYMPTOMS

KW - GYNECOLOGICAL CANCER

KW - INTESTINAL BACTERIAL OVERGROWTH

KW - MANAGEMENT

KW - PATHOGENESIS

KW - RADIOTHERAPY

KW - RESECTION

KW - Prospective Studies

KW - Colorectal Neoplasms/complications

KW - Humans

KW - Middle Aged

KW - Fecal Incontinence/etiology

KW - Male

KW - Ovarian Neoplasms/complications

KW - Steatorrhea/etiology

KW - Adult

KW - Female

KW - Cholestyramine Resin/therapeutic use

KW - Treatment Outcome

KW - Diarrhea/etiology

KW - Prostatic Neoplasms/complications

KW - Uterine Neoplasms/complications

KW - Gastrointestinal Diseases/diet therapy

KW - Aged

KW - Anti-Bacterial Agents/therapeutic use

KW - Chronic Disease

KW - Bile Acids and Salts/metabolism

U2 - 10.1080/0284186X.2018.1562211

DO - 10.1080/0284186X.2018.1562211

M3 - Journal article

C2 - 30698052

VL - 58

SP - 776

EP - 781

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 5

ER -