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Asbjørn Mohr Drewes

Cerebral excitability is abnormal in patients with painful chronic pancreatitis

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Cerebral excitability is abnormal in patients with painful chronic pancreatitis. / Olesen, S S; Hansen, T M; Graversen, C; Valeriani, Massimiliano; Drewes, A M.

I: European Journal of Pain, 2012.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Olesen, S S ; Hansen, T M ; Graversen, C ; Valeriani, Massimiliano ; Drewes, A M. / Cerebral excitability is abnormal in patients with painful chronic pancreatitis. I: European Journal of Pain. 2012.

Bibtex

@article{22ce703c9068427c81647d73ff318de7,
title = "Cerebral excitability is abnormal in patients with painful chronic pancreatitis",
abstract = "BACKGROUND: We investigated whether patients with painful chronic pancreatitis (CP) present abnormalities in the cerebral response to experimental pain stimuli. METHODS: Contact heat-evoked potentials (CHEPS) were recorded in 15 patients with CP and in 15 healthy volunteers during repetitive stimulation of the upper abdominal region (pancreatic 'viscerotome') and the right forearm (heterologous area). Three sequences of painful stimuli were applied at each site. Subjective pain scores were assessed by a visual analogue scale. Habituation was calculated as the relative change in CHEPS amplitudes between the first and the third stimulation sequence. RESULTS: As expected pain scores decreased in healthy volunteers during successive stimulations at both sites (i.e., habituation), while in the CP group, they remained unchanged. The cerebral response consisted of an early-latency, low-amplitude response (N1, contralateral temporal region) followed by a late, high-amplitude, negative-positive complex (N2/P2, vertex). During successive stimulation of the pancreatic area, N2/P2 amplitude increased 25% in CP patients, while they decreased 20% in healthy volunteers (p = 0.006). After stimulation of the forearm, N2/P2 amplitudes increased 3% in CP patients compared to a decrease of 20% in healthy volunteers (p = 0.06). CONCLUSIONS: Taken together, CP patients had an abnormal cerebral response to repetitive thermal stimuli. This was most prominent after stimulation of the upper abdominal area. As this area share spinal innervation with the pancreatic gland, these findings likely mirror distinctive abnormalities in cerebral pain processing.",
author = "Olesen, {S S} and Hansen, {T M} and C Graversen and Massimiliano Valeriani and Drewes, {A M}",
note = "{\textcopyright} 2012 European Federation of International Association for the Study of Pain Chapters.",
year = "2012",
doi = "10.1002/j.1532-2149.2012.00155.x",
language = "English",
journal = "European Journal of Pain",
issn = "1090-3801",
publisher = "JohnWiley & Sons Ltd.",

}

RIS

TY - JOUR

T1 - Cerebral excitability is abnormal in patients with painful chronic pancreatitis

AU - Olesen, S S

AU - Hansen, T M

AU - Graversen, C

AU - Valeriani, Massimiliano

AU - Drewes, A M

N1 - © 2012 European Federation of International Association for the Study of Pain Chapters.

PY - 2012

Y1 - 2012

N2 - BACKGROUND: We investigated whether patients with painful chronic pancreatitis (CP) present abnormalities in the cerebral response to experimental pain stimuli. METHODS: Contact heat-evoked potentials (CHEPS) were recorded in 15 patients with CP and in 15 healthy volunteers during repetitive stimulation of the upper abdominal region (pancreatic 'viscerotome') and the right forearm (heterologous area). Three sequences of painful stimuli were applied at each site. Subjective pain scores were assessed by a visual analogue scale. Habituation was calculated as the relative change in CHEPS amplitudes between the first and the third stimulation sequence. RESULTS: As expected pain scores decreased in healthy volunteers during successive stimulations at both sites (i.e., habituation), while in the CP group, they remained unchanged. The cerebral response consisted of an early-latency, low-amplitude response (N1, contralateral temporal region) followed by a late, high-amplitude, negative-positive complex (N2/P2, vertex). During successive stimulation of the pancreatic area, N2/P2 amplitude increased 25% in CP patients, while they decreased 20% in healthy volunteers (p = 0.006). After stimulation of the forearm, N2/P2 amplitudes increased 3% in CP patients compared to a decrease of 20% in healthy volunteers (p = 0.06). CONCLUSIONS: Taken together, CP patients had an abnormal cerebral response to repetitive thermal stimuli. This was most prominent after stimulation of the upper abdominal area. As this area share spinal innervation with the pancreatic gland, these findings likely mirror distinctive abnormalities in cerebral pain processing.

AB - BACKGROUND: We investigated whether patients with painful chronic pancreatitis (CP) present abnormalities in the cerebral response to experimental pain stimuli. METHODS: Contact heat-evoked potentials (CHEPS) were recorded in 15 patients with CP and in 15 healthy volunteers during repetitive stimulation of the upper abdominal region (pancreatic 'viscerotome') and the right forearm (heterologous area). Three sequences of painful stimuli were applied at each site. Subjective pain scores were assessed by a visual analogue scale. Habituation was calculated as the relative change in CHEPS amplitudes between the first and the third stimulation sequence. RESULTS: As expected pain scores decreased in healthy volunteers during successive stimulations at both sites (i.e., habituation), while in the CP group, they remained unchanged. The cerebral response consisted of an early-latency, low-amplitude response (N1, contralateral temporal region) followed by a late, high-amplitude, negative-positive complex (N2/P2, vertex). During successive stimulation of the pancreatic area, N2/P2 amplitude increased 25% in CP patients, while they decreased 20% in healthy volunteers (p = 0.006). After stimulation of the forearm, N2/P2 amplitudes increased 3% in CP patients compared to a decrease of 20% in healthy volunteers (p = 0.06). CONCLUSIONS: Taken together, CP patients had an abnormal cerebral response to repetitive thermal stimuli. This was most prominent after stimulation of the upper abdominal area. As this area share spinal innervation with the pancreatic gland, these findings likely mirror distinctive abnormalities in cerebral pain processing.

U2 - 10.1002/j.1532-2149.2012.00155.x

DO - 10.1002/j.1532-2149.2012.00155.x

M3 - Journal article

C2 - 22508470

JO - European Journal of Pain

JF - European Journal of Pain

SN - 1090-3801

ER -