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Asbjørn Mohr Drewes

Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms. / Frøkjær, Jens Brøndum; Søfteland, Eirik; Graversen, Carina; Dimcevski, Georg; Egsgaard, Line Lindhardt; Arendt-Nielsen, Lars; Mohr Drewes, Asbjørn.

I: Diabetes Care, Bind 32, Nr. 7, 2009, s. 1274-1277.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Frøkjær, JB, Søfteland, E, Graversen, C, Dimcevski, G, Egsgaard, LL, Arendt-Nielsen, L & Mohr Drewes, A 2009, 'Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms', Diabetes Care, bind 32, nr. 7, s. 1274-1277. https://doi.org/10.2337/dc09-0324

APA

Frøkjær, J. B., Søfteland, E., Graversen, C., Dimcevski, G., Egsgaard, L. L., Arendt-Nielsen, L., & Mohr Drewes, A. (2009). Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms. Diabetes Care, 32(7), 1274-1277. https://doi.org/10.2337/dc09-0324

CBE

Frøkjær JB, Søfteland E, Graversen C, Dimcevski G, Egsgaard LL, Arendt-Nielsen L, Mohr Drewes A. 2009. Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms. Diabetes Care. 32(7):1274-1277. https://doi.org/10.2337/dc09-0324

MLA

Vancouver

Frøkjær JB, Søfteland E, Graversen C, Dimcevski G, Egsgaard LL, Arendt-Nielsen L o.a. Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms. Diabetes Care. 2009;32(7):1274-1277. https://doi.org/10.2337/dc09-0324

Author

Frøkjær, Jens Brøndum ; Søfteland, Eirik ; Graversen, Carina ; Dimcevski, Georg ; Egsgaard, Line Lindhardt ; Arendt-Nielsen, Lars ; Mohr Drewes, Asbjørn. / Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms. I: Diabetes Care. 2009 ; Bind 32, Nr. 7. s. 1274-1277.

Bibtex

@article{4a3248403b0811de8dc9000ea68e967b,
title = "Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms",
abstract = "Objective: To evaluate the brain responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. Design and methods: The sensitivity to electrical esophageal and median nerve stimulations were assessed in 15 healthy volunteers and 14 type-1 diabetic patients with autonomic neuropathy and gastrointestinal symptoms using an euglycemic hyperinsulinemic clamp. Evoked brain potentials were recorded. Results: Patients had reduced sensitivity to esophageal (48%; P<0.001) and median nerve (80%; P<0.001) stimulations. They also had increased 8.8% (P=0.007) and non-reproducible (P=0.006) latencies of evoked potentials to esophageal stimulations with 26% reduction in amplitude (P=0.011). No potential differences were seen to median nerve stimulations. In diabetics the topographic location of the first peak in potentials was more centrally (P<0.001) and gastrointestinal symptoms were correlated to characteristics of brain potentials (P=0.049). Conclusions: This study supports that diabetes induces changes in peripheral visceral nerves as well as in the central nervous system.",
author = "Fr{\o}kj{\ae}r, {Jens Br{\o}ndum} and Eirik S{\o}fteland and Carina Graversen and Georg Dimcevski and Egsgaard, {Line Lindhardt} and Lars Arendt-Nielsen and {Mohr Drewes}, Asbj{\o}rn",
year = "2009",
doi = "10.2337/dc09-0324",
language = "English",
volume = "32",
pages = "1274--1277",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "7",

}

RIS

TY - JOUR

T1 - Central Processing of Gut Pain in Diabetes Patients with Gastrointestinal Symptoms

AU - Frøkjær, Jens Brøndum

AU - Søfteland, Eirik

AU - Graversen, Carina

AU - Dimcevski, Georg

AU - Egsgaard, Line Lindhardt

AU - Arendt-Nielsen, Lars

AU - Mohr Drewes, Asbjørn

PY - 2009

Y1 - 2009

N2 - Objective: To evaluate the brain responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. Design and methods: The sensitivity to electrical esophageal and median nerve stimulations were assessed in 15 healthy volunteers and 14 type-1 diabetic patients with autonomic neuropathy and gastrointestinal symptoms using an euglycemic hyperinsulinemic clamp. Evoked brain potentials were recorded. Results: Patients had reduced sensitivity to esophageal (48%; P<0.001) and median nerve (80%; P<0.001) stimulations. They also had increased 8.8% (P=0.007) and non-reproducible (P=0.006) latencies of evoked potentials to esophageal stimulations with 26% reduction in amplitude (P=0.011). No potential differences were seen to median nerve stimulations. In diabetics the topographic location of the first peak in potentials was more centrally (P<0.001) and gastrointestinal symptoms were correlated to characteristics of brain potentials (P=0.049). Conclusions: This study supports that diabetes induces changes in peripheral visceral nerves as well as in the central nervous system.

AB - Objective: To evaluate the brain responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. Design and methods: The sensitivity to electrical esophageal and median nerve stimulations were assessed in 15 healthy volunteers and 14 type-1 diabetic patients with autonomic neuropathy and gastrointestinal symptoms using an euglycemic hyperinsulinemic clamp. Evoked brain potentials were recorded. Results: Patients had reduced sensitivity to esophageal (48%; P<0.001) and median nerve (80%; P<0.001) stimulations. They also had increased 8.8% (P=0.007) and non-reproducible (P=0.006) latencies of evoked potentials to esophageal stimulations with 26% reduction in amplitude (P=0.011). No potential differences were seen to median nerve stimulations. In diabetics the topographic location of the first peak in potentials was more centrally (P<0.001) and gastrointestinal symptoms were correlated to characteristics of brain potentials (P=0.049). Conclusions: This study supports that diabetes induces changes in peripheral visceral nerves as well as in the central nervous system.

U2 - 10.2337/dc09-0324

DO - 10.2337/dc09-0324

M3 - Journal article

C2 - 19366960

VL - 32

SP - 1274

EP - 1277

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 7

ER -