Asbjørn Mohr Drewes

Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes

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Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes. / Hansen, Tine Maria; Brock, Birgitte; Juhl, Anne; Drewes, Asbjørn Mohr; Vorum, Henrik; Andersen, Carl Uggerhøj; Jakobsen, Poul Erik; Karmisholt, Jesper Scott; Frøkjær, Jens Brøndum; Brock, Christina.

I: Journal of Diabetes and its Complications, Bind 33, Nr. 4, 2019, s. 323-328.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Hansen, Tine Maria ; Brock, Birgitte ; Juhl, Anne ; Drewes, Asbjørn Mohr ; Vorum, Henrik ; Andersen, Carl Uggerhøj ; Jakobsen, Poul Erik ; Karmisholt, Jesper Scott ; Frøkjær, Jens Brøndum ; Brock, Christina. / Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes. I: Journal of Diabetes and its Complications. 2019 ; Bind 33, Nr. 4. s. 323-328.

Bibtex

@article{fece78f8646941618d025a4d981ff8fe,
title = "Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes",
abstract = "Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics. Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Results: Adults with diabetes had 9.3{\%} lower ratio of N-acetylaspartate/creatine (NAA/cre) in comparison to healthy (p < 0.001). Lower NAA/cre was associated with lower sural (p = 0.01) and tibial (p = 0.04) nerve amplitudes, longer diabetes duration (p = 0.03) and higher age (p = 0.03). In addition, NAA/cre was significantly lower in the subgroup with proliferative retinopathy as compared to the subgroup with non-proliferative retinopathy (p = 0.02). Conclusions: The association to peripheral nerve dysfunction, indicates concomitant presence of DSPN and central neuropathies, supporting the increasing recognition of diabetic neuropathy being, at least partly, a disease leading to polyneuropathy. Decreased NAA, is a potential promising biomarker of central neuronal dysfunction or loss, and thus may be useful to measure progression of neuropathy in diabetes or other neurodegenerative diseases.",
keywords = "Central nervous system, Diabetes neuropathy, Magnetic resonance spectroscopy, Metabolites, N-acetylaspartate, Peripheral neuropathy",
author = "Hansen, {Tine Maria} and Birgitte Brock and Anne Juhl and Drewes, {Asbj{\o}rn Mohr} and Henrik Vorum and Andersen, {Carl Uggerh{\o}j} and Jakobsen, {Poul Erik} and Karmisholt, {Jesper Scott} and Fr{\o}kj{\ae}r, {Jens Br{\o}ndum} and Christina Brock",
year = "2019",
doi = "10.1016/j.jdiacomp.2018.12.016",
language = "English",
volume = "33",
pages = "323--328",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc",
number = "4",

}

RIS

TY - JOUR

T1 - Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes

AU - Hansen, Tine Maria

AU - Brock, Birgitte

AU - Juhl, Anne

AU - Drewes, Asbjørn Mohr

AU - Vorum, Henrik

AU - Andersen, Carl Uggerhøj

AU - Jakobsen, Poul Erik

AU - Karmisholt, Jesper Scott

AU - Frøkjær, Jens Brøndum

AU - Brock, Christina

PY - 2019

Y1 - 2019

N2 - Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics. Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Results: Adults with diabetes had 9.3% lower ratio of N-acetylaspartate/creatine (NAA/cre) in comparison to healthy (p < 0.001). Lower NAA/cre was associated with lower sural (p = 0.01) and tibial (p = 0.04) nerve amplitudes, longer diabetes duration (p = 0.03) and higher age (p = 0.03). In addition, NAA/cre was significantly lower in the subgroup with proliferative retinopathy as compared to the subgroup with non-proliferative retinopathy (p = 0.02). Conclusions: The association to peripheral nerve dysfunction, indicates concomitant presence of DSPN and central neuropathies, supporting the increasing recognition of diabetic neuropathy being, at least partly, a disease leading to polyneuropathy. Decreased NAA, is a potential promising biomarker of central neuronal dysfunction or loss, and thus may be useful to measure progression of neuropathy in diabetes or other neurodegenerative diseases.

AB - Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics. Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Results: Adults with diabetes had 9.3% lower ratio of N-acetylaspartate/creatine (NAA/cre) in comparison to healthy (p < 0.001). Lower NAA/cre was associated with lower sural (p = 0.01) and tibial (p = 0.04) nerve amplitudes, longer diabetes duration (p = 0.03) and higher age (p = 0.03). In addition, NAA/cre was significantly lower in the subgroup with proliferative retinopathy as compared to the subgroup with non-proliferative retinopathy (p = 0.02). Conclusions: The association to peripheral nerve dysfunction, indicates concomitant presence of DSPN and central neuropathies, supporting the increasing recognition of diabetic neuropathy being, at least partly, a disease leading to polyneuropathy. Decreased NAA, is a potential promising biomarker of central neuronal dysfunction or loss, and thus may be useful to measure progression of neuropathy in diabetes or other neurodegenerative diseases.

KW - Central nervous system

KW - Diabetes neuropathy

KW - Magnetic resonance spectroscopy

KW - Metabolites

KW - N-acetylaspartate

KW - Peripheral neuropathy

UR - http://www.scopus.com/inward/record.url?scp=85060999360&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2018.12.016

DO - 10.1016/j.jdiacomp.2018.12.016

M3 - Journal article

C2 - 30733057

AN - SCOPUS:85060999360

VL - 33

SP - 323

EP - 328

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 4

ER -