Asbjørn Mohr Drewes

Brain changes in diabetes mellitus patients with gastrointestinal symptoms

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Brain changes in diabetes mellitus patients with gastrointestinal symptoms. / Drewes, Anne Mohr; Søfteland, Eirik; Dimcevski, Georg; Farmer, Adam D; Brock, Christina; Frøkjær, Jens B; Krogh, Klaus; Drewes, Asbjørn M.

I: World Journal of Diabetes, Bind 7, Nr. 2, 25.01.2016, s. 14-26.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Drewes, AM, Søfteland, E, Dimcevski, G, Farmer, AD, Brock, C, Frøkjær, JB, Krogh, K & Drewes, AM 2016, 'Brain changes in diabetes mellitus patients with gastrointestinal symptoms', World Journal of Diabetes, bind 7, nr. 2, s. 14-26. https://doi.org/10.4239/wjd.v7.i2.14

APA

Drewes, A. M., Søfteland, E., Dimcevski, G., Farmer, A. D., Brock, C., Frøkjær, J. B., Krogh, K., & Drewes, A. M. (2016). Brain changes in diabetes mellitus patients with gastrointestinal symptoms. World Journal of Diabetes, 7(2), 14-26. https://doi.org/10.4239/wjd.v7.i2.14

CBE

Drewes AM, Søfteland E, Dimcevski G, Farmer AD, Brock C, Frøkjær JB, Krogh K, Drewes AM. 2016. Brain changes in diabetes mellitus patients with gastrointestinal symptoms. World Journal of Diabetes. 7(2):14-26. https://doi.org/10.4239/wjd.v7.i2.14

MLA

Vancouver

Drewes AM, Søfteland E, Dimcevski G, Farmer AD, Brock C, Frøkjær JB o.a. Brain changes in diabetes mellitus patients with gastrointestinal symptoms. World Journal of Diabetes. 2016 jan 25;7(2):14-26. https://doi.org/10.4239/wjd.v7.i2.14

Author

Drewes, Anne Mohr ; Søfteland, Eirik ; Dimcevski, Georg ; Farmer, Adam D ; Brock, Christina ; Frøkjær, Jens B ; Krogh, Klaus ; Drewes, Asbjørn M. / Brain changes in diabetes mellitus patients with gastrointestinal symptoms. I: World Journal of Diabetes. 2016 ; Bind 7, Nr. 2. s. 14-26.

Bibtex

@article{077025fdf09c4c5ea79f398bd5c5c04f,
title = "Brain changes in diabetes mellitus patients with gastrointestinal symptoms",
abstract = "Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system (CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal (GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testing mainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes, especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation.",
keywords = "Journal Article, Review",
author = "Drewes, {Anne Mohr} and Eirik S{\o}fteland and Georg Dimcevski and Farmer, {Adam D} and Christina Brock and Fr{\o}kj{\ae}r, {Jens B} and Klaus Krogh and Drewes, {Asbj{\o}rn M}",
year = "2016",
month = jan,
day = "25",
doi = "10.4239/wjd.v7.i2.14",
language = "English",
volume = "7",
pages = "14--26",
journal = "World Journal of Diabetes",
issn = "1948-9358",
publisher = "Baishideng Publishing Group Co., Limited",
number = "2",

}

RIS

TY - JOUR

T1 - Brain changes in diabetes mellitus patients with gastrointestinal symptoms

AU - Drewes, Anne Mohr

AU - Søfteland, Eirik

AU - Dimcevski, Georg

AU - Farmer, Adam D

AU - Brock, Christina

AU - Frøkjær, Jens B

AU - Krogh, Klaus

AU - Drewes, Asbjørn M

PY - 2016/1/25

Y1 - 2016/1/25

N2 - Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system (CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal (GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testing mainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes, especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation.

AB - Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system (CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal (GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testing mainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes, especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation.

KW - Journal Article

KW - Review

U2 - 10.4239/wjd.v7.i2.14

DO - 10.4239/wjd.v7.i2.14

M3 - Journal article

C2 - 26839652

VL - 7

SP - 14

EP - 26

JO - World Journal of Diabetes

JF - World Journal of Diabetes

SN - 1948-9358

IS - 2

ER -