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Asbjørn Mohr Drewes

Brain activity in rectosigmoid pain: Unravelling conditioning pain modulatory pathways

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OBJECTIVE: Conditioning Pain Modulation (CPM) represents the various descending inhibitory mechanisms induced by a heterotopic noxious stimulation (previously termed DNIC). CPM-induced modulations in brain activity have not previously been investigated to visceral pain. Hence the aims were to assess the role of CPM in terms of: (1) psychophysics, (2) alterations in topography and amplitudes of evoked brain potentials and (3) modelling the brain activity. METHODS: Fifteen healthy volunteers were stimulated electrically in the rectosigmoid, and 64-channel brain activity was recorded two times before (reproducibility), during and after induction of CPM by immersing the non-dominant hand into water at 2°C for 180s (cold pressor). RESULTS: During CPM pain scores were reduced in comparison to baseline (P⩽0.001), which corresponds to 30% pain attenuation. In comparison to baseline significant differences in bipolar EEG topography were seen during CPM, where N2 moved from central to frontal activity (P
TidsskriftClinical Neurophysiology
Sider (fra-til)829-37
Antal sider9
StatusUdgivet - 2012

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