Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

Autoimmune pancreatitis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Autoimmune pancreatitis. / Detlefsen, Sönke; Drewes, Asbjørn M.

I: Scandinavian Journal of Gastroenterology, Bind 44, Nr. 12, 2009, s. 1391-407.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Detlefsen, S & Drewes, AM 2009, 'Autoimmune pancreatitis', Scandinavian Journal of Gastroenterology, bind 44, nr. 12, s. 1391-407. https://doi.org/10.3109/00365520903358881

APA

Detlefsen, S., & Drewes, A. M. (2009). Autoimmune pancreatitis. Scandinavian Journal of Gastroenterology, 44(12), 1391-407. https://doi.org/10.3109/00365520903358881

CBE

Detlefsen S, Drewes AM. 2009. Autoimmune pancreatitis. Scandinavian Journal of Gastroenterology. 44(12):1391-407. https://doi.org/10.3109/00365520903358881

MLA

Detlefsen, Sönke og Asbjørn M Drewes. "Autoimmune pancreatitis". Scandinavian Journal of Gastroenterology. 2009, 44(12). 1391-407. https://doi.org/10.3109/00365520903358881

Vancouver

Detlefsen S, Drewes AM. Autoimmune pancreatitis. Scandinavian Journal of Gastroenterology. 2009;44(12):1391-407. https://doi.org/10.3109/00365520903358881

Author

Detlefsen, Sönke ; Drewes, Asbjørn M. / Autoimmune pancreatitis. I: Scandinavian Journal of Gastroenterology. 2009 ; Bind 44, Nr. 12. s. 1391-407.

Bibtex

@article{43cba2e0206c11dfb95d000ea68e967b,
title = "Autoimmune pancreatitis",
abstract = "BACKGROUND: Autoimmune pancreatitis (AIP) is a relatively newly recognized type of pancreatitis that is characterized by diffuse or focal swelling of the pancreas due to lymphoplasmacytic infiltration and fibrosis of the pancreatic parenchyma. MATERIAL AND METHODS: A PubMed literature search was performed using the keywords {"}autoimmune pancreatitis{"}. Sometimes, bibliographies were cross-referenced and related article searches were performed once an article of interest was identified. RESULTS: Pathologically, AIP shows narrowing of the pancreatic ducts and the intrapancreatic portion of the common bile duct. Obstructive jaundice is a common symptom at presentation, and pancreatic cancer represents an important clinical differential diagnosis. In late stages of the disease, the normal pancreatic parenchyma is often replaced by large amounts of fibrosis. Histologically, there seem to be two subtypes of the disease-one showing infiltration with IgG4-positive plasma cells but lacking granulocytic epithelial lesions (GELs), the other showing GELs but lacking strong IgG4 positivity. AIP is in at least some instances the pancreatic manifestation of a clinicopathological entity of IgG4-related systemic sclerosing disease. On the basis of pancreatic imaging, together with serological measurement of IgG4 and evaluation of other organ involvement, many AIP patients can be identified. The remaining patients require further diagnostic work-up. In these patients, pancreatic core needle biopsy and, as AIP responds to steroid treatment, also a trial with steroids, can help to differentiate AIP from pancreatic cancer. OUTLOOK AND DISCUSSION: This review presents the pathological, radiologic and laboratory findings of AIP. Moreover, the treatment and pathogenesis are discussed.",
author = "S{\"o}nke Detlefsen and Drewes, {Asbj{\o}rn M}",
year = "2009",
doi = "10.3109/00365520903358881",
language = "English",
volume = "44",
pages = "1391--407",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis ",
number = "12",

}

RIS

TY - JOUR

T1 - Autoimmune pancreatitis

AU - Detlefsen, Sönke

AU - Drewes, Asbjørn M

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Autoimmune pancreatitis (AIP) is a relatively newly recognized type of pancreatitis that is characterized by diffuse or focal swelling of the pancreas due to lymphoplasmacytic infiltration and fibrosis of the pancreatic parenchyma. MATERIAL AND METHODS: A PubMed literature search was performed using the keywords "autoimmune pancreatitis". Sometimes, bibliographies were cross-referenced and related article searches were performed once an article of interest was identified. RESULTS: Pathologically, AIP shows narrowing of the pancreatic ducts and the intrapancreatic portion of the common bile duct. Obstructive jaundice is a common symptom at presentation, and pancreatic cancer represents an important clinical differential diagnosis. In late stages of the disease, the normal pancreatic parenchyma is often replaced by large amounts of fibrosis. Histologically, there seem to be two subtypes of the disease-one showing infiltration with IgG4-positive plasma cells but lacking granulocytic epithelial lesions (GELs), the other showing GELs but lacking strong IgG4 positivity. AIP is in at least some instances the pancreatic manifestation of a clinicopathological entity of IgG4-related systemic sclerosing disease. On the basis of pancreatic imaging, together with serological measurement of IgG4 and evaluation of other organ involvement, many AIP patients can be identified. The remaining patients require further diagnostic work-up. In these patients, pancreatic core needle biopsy and, as AIP responds to steroid treatment, also a trial with steroids, can help to differentiate AIP from pancreatic cancer. OUTLOOK AND DISCUSSION: This review presents the pathological, radiologic and laboratory findings of AIP. Moreover, the treatment and pathogenesis are discussed.

AB - BACKGROUND: Autoimmune pancreatitis (AIP) is a relatively newly recognized type of pancreatitis that is characterized by diffuse or focal swelling of the pancreas due to lymphoplasmacytic infiltration and fibrosis of the pancreatic parenchyma. MATERIAL AND METHODS: A PubMed literature search was performed using the keywords "autoimmune pancreatitis". Sometimes, bibliographies were cross-referenced and related article searches were performed once an article of interest was identified. RESULTS: Pathologically, AIP shows narrowing of the pancreatic ducts and the intrapancreatic portion of the common bile duct. Obstructive jaundice is a common symptom at presentation, and pancreatic cancer represents an important clinical differential diagnosis. In late stages of the disease, the normal pancreatic parenchyma is often replaced by large amounts of fibrosis. Histologically, there seem to be two subtypes of the disease-one showing infiltration with IgG4-positive plasma cells but lacking granulocytic epithelial lesions (GELs), the other showing GELs but lacking strong IgG4 positivity. AIP is in at least some instances the pancreatic manifestation of a clinicopathological entity of IgG4-related systemic sclerosing disease. On the basis of pancreatic imaging, together with serological measurement of IgG4 and evaluation of other organ involvement, many AIP patients can be identified. The remaining patients require further diagnostic work-up. In these patients, pancreatic core needle biopsy and, as AIP responds to steroid treatment, also a trial with steroids, can help to differentiate AIP from pancreatic cancer. OUTLOOK AND DISCUSSION: This review presents the pathological, radiologic and laboratory findings of AIP. Moreover, the treatment and pathogenesis are discussed.

U2 - 10.3109/00365520903358881

DO - 10.3109/00365520903358881

M3 - Journal article

C2 - 19958057

VL - 44

SP - 1391

EP - 1407

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 12

ER -