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Asbjørn Mohr Drewes

Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. / Burgell, R E; Lelic, D; Carrington, E V; Lunniss, P J; Olesen, S S; Surguy, S; Drewes, A M; Scott, S M.

I: Neurogastroenterology and Motility Online, 2012.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Burgell, RE, Lelic, D, Carrington, EV, Lunniss, PJ, Olesen, SS, Surguy, S, Drewes, AM & Scott, SM 2012, 'Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity', Neurogastroenterology and Motility Online. https://doi.org/10.1111/nmo.12047

APA

Burgell, R. E., Lelic, D., Carrington, E. V., Lunniss, P. J., Olesen, S. S., Surguy, S., Drewes, A. M., & Scott, S. M. (2012). Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. Neurogastroenterology and Motility Online. https://doi.org/10.1111/nmo.12047

CBE

Burgell RE, Lelic D, Carrington EV, Lunniss PJ, Olesen SS, Surguy S, Drewes AM, Scott SM. 2012. Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. Neurogastroenterology and Motility Online. https://doi.org/10.1111/nmo.12047

MLA

Vancouver

Burgell RE, Lelic D, Carrington EV, Lunniss PJ, Olesen SS, Surguy S o.a. Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. Neurogastroenterology and Motility Online. 2012. https://doi.org/10.1111/nmo.12047

Author

Burgell, R E ; Lelic, D ; Carrington, E V ; Lunniss, P J ; Olesen, S S ; Surguy, S ; Drewes, A M ; Scott, S M. / Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. I: Neurogastroenterology and Motility Online. 2012.

Bibtex

@article{b07557769d114272becc14ea7db4a3f4,
title = "Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity",
abstract = "Background  Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined. Methods  Rectal EPs (64 channels) were recorded in 13 patients with constipation and RH (elevated thresholds to balloon distension) and 11 healthy controls, in response to electrical stimulation of the rectum at 10 cm from the anal verge using a bipolar stimulating electrode. Stimuli were delivered at pain threshold. Evoked potential peak latencies and amplitudes were analyzed, and inverse modeling was performed on traces obtained to determine the location of cortical generators. Key Results  Pain threshold was higher in patients than controls [median 59 (range 23-80) mA vs 24 (10-55) mA; P = 0.007]. Median latency to the first negative peak was 142 (±24) ms in subjects compared with 116 (±15) ms in controls (P = 0.004). There was no difference in topographic analysis of EPs or location of cortical activity demonstrated by inverse modeling between groups. Conclusions & Inferences  This study is the first showing objective evidence of alteration in the rectal afferent pathway of individuals with RH and constipation. Prolonged latencies suggest a primary defect in sensory neuronal function, while cerebral processing of visceral sensory information appears normal.",
author = "Burgell, {R E} and D Lelic and Carrington, {E V} and Lunniss, {P J} and Olesen, {S S} and S Surguy and Drewes, {A M} and Scott, {S M}",
note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",
year = "2012",
doi = "10.1111/nmo.12047",
language = "English",
journal = "Neurogastroenterology and Motility Online",
issn = "1365-2982",
publisher = "Wiley-Blackwell Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

AU - Burgell, R E

AU - Lelic, D

AU - Carrington, E V

AU - Lunniss, P J

AU - Olesen, S S

AU - Surguy, S

AU - Drewes, A M

AU - Scott, S M

N1 - © 2012 Blackwell Publishing Ltd.

PY - 2012

Y1 - 2012

N2 - Background  Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined. Methods  Rectal EPs (64 channels) were recorded in 13 patients with constipation and RH (elevated thresholds to balloon distension) and 11 healthy controls, in response to electrical stimulation of the rectum at 10 cm from the anal verge using a bipolar stimulating electrode. Stimuli were delivered at pain threshold. Evoked potential peak latencies and amplitudes were analyzed, and inverse modeling was performed on traces obtained to determine the location of cortical generators. Key Results  Pain threshold was higher in patients than controls [median 59 (range 23-80) mA vs 24 (10-55) mA; P = 0.007]. Median latency to the first negative peak was 142 (±24) ms in subjects compared with 116 (±15) ms in controls (P = 0.004). There was no difference in topographic analysis of EPs or location of cortical activity demonstrated by inverse modeling between groups. Conclusions & Inferences  This study is the first showing objective evidence of alteration in the rectal afferent pathway of individuals with RH and constipation. Prolonged latencies suggest a primary defect in sensory neuronal function, while cerebral processing of visceral sensory information appears normal.

AB - Background  Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined. Methods  Rectal EPs (64 channels) were recorded in 13 patients with constipation and RH (elevated thresholds to balloon distension) and 11 healthy controls, in response to electrical stimulation of the rectum at 10 cm from the anal verge using a bipolar stimulating electrode. Stimuli were delivered at pain threshold. Evoked potential peak latencies and amplitudes were analyzed, and inverse modeling was performed on traces obtained to determine the location of cortical generators. Key Results  Pain threshold was higher in patients than controls [median 59 (range 23-80) mA vs 24 (10-55) mA; P = 0.007]. Median latency to the first negative peak was 142 (±24) ms in subjects compared with 116 (±15) ms in controls (P = 0.004). There was no difference in topographic analysis of EPs or location of cortical activity demonstrated by inverse modeling between groups. Conclusions & Inferences  This study is the first showing objective evidence of alteration in the rectal afferent pathway of individuals with RH and constipation. Prolonged latencies suggest a primary defect in sensory neuronal function, while cerebral processing of visceral sensory information appears normal.

U2 - 10.1111/nmo.12047

DO - 10.1111/nmo.12047

M3 - Journal article

C2 - 23240734

JO - Neurogastroenterology and Motility Online

JF - Neurogastroenterology and Motility Online

SN - 1365-2982

ER -