Asbjørn Mohr Drewes

Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Esben Bolvig Mark, Aalborg University Hospital, Psychiatry, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • ,
  • Jakob Lykke Poulsen, Aalborg University Hospital, Psychiatry, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • ,
  • Anne-Mette Haase
  • Marie Espersen, Mech-Sense, Department of Gastroenterology and Hepatology, Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Tine Gregersen
  • Vincent Schlageter, Motilis Medica SA, Lausanne, Switzerland.
  • ,
  • S Mark Scott, Neurogastroenterology Group (GI Physiology Unit), Queen Mary University, London, UK.
  • ,
  • Klaus Krogh
  • Asbjørn Mohr Drewes

Background: The Motilis 3D-Transit system tracks electromagnetic capsules as they traverse the gastrointestinal tract. The method is minimally invasive and ambulatory. Analysis has previously been limited to regional gut transit times, but new methods may allow detailed analysis of colonic motility. Methods: Parameters of colonic motility were analyzed from 34 3D-Transit recordings performed in healthy volunteers (median age 28 years; 8 F). Characteristic propulsive velocities and lengths of movement were determined to quantify common movement patterns. Data from seven patients with severe chronic diarrhea were included for comparison. Key Results: Lack of capsule motion accounted for 82% (75%-87%) of total colonic transit time. Propulsive velocities were distributed with peaks at 0.5 cm/min (antegrade or retrograde) and 50 cm/min (antegrade). Based on velocity and length of propagation, five motor patterns were identified; (a) long fast antegrade, (b) fast antegrade, (c) slow antegrade, (d) slow retrograde, and (e) fast retrograde movements. Long fast antegrade movements were median 21 cm (10-96 cm). Capsule progression was faster during daytime than at night (5.9 cm/h vs 0.8 cm/h; P < 0.01). Colonic transit was faster in patients with chronic diarrhea than in healthy volunteers (5.4 h vs 18.2 h; P = 0.04), with higher capsule velocity (20.4 cm/h vs 4.4 cm/h; P < 0.01). Conclusions and Inferences: The 3D-Transit system now allows detailed description of colonic motility and our results are supported by those previously suggested by manometry. It holds promise for future assessment of movement patterns to characterize different diseases and effects of treatment.

OriginalsprogEngelsk
Artikelnummere13451
TidsskriftNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Vol/bind31
Nummer2
Antal sider11
ISSN1365-2982
DOI
StatusUdgivet - feb. 2019

Bibliografisk note

© 2018 John Wiley & Sons Ltd.

Se relationer på Aarhus Universitet Citationsformater

ID: 138243560