Asbjørn Mohr Drewes

Altered Brain Microstructure assessed by Diffusion Tensor Imaging in Patients with Diabetes Mellitus and Gastrointestinal Symptoms

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Jens Brøndum Frøkjær, Department of Radiology, Aalborg Hospital, Danmark
  • Lars Wiuff Andersen
  • Christina Brock, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Danmark
  • Magnus Simrén, University of Gothenburg, Sverige
  • Maria Ljungberg, University of Gothenburg, Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sverige
  • Eirik Søfteland, Department of Medicine, Haukeland University Hospital and Institute of Medicine, University of Bergen, Norge
  • Georg Dimcevski, Norge
  • Yousef Yavarian
  • Hans Gregersen, Sino-Danish Centre for Education and Research, Aarhus, Danmark
  • Asbjørn Mohr Drewes
OBJECTIVE In patients with long-standing diabetes mellitus (DM), there is increasing evidence for abnormal processing of gastrointestinal sensations in the central nervous system. Using magnetic resonance diffusion tensor imaging, we characterized brain microstructure in areas involved in visceral sensory processing and correlated these findings to clinical parameters.

RESEARCH DESIGN AND METHODS Twenty-six patients with DM and gastrointestinal symptoms and 23 healthy control subjects were studied in a 3T scanner. The apparent diffusion coefficient (i.e., diffusivity of water) and fractional anisotropy (FA) (i.e., organization of fibers) were assessed in the “sensory matrix” (cingulate cortex, insula, prefrontal and secondary sensory cortex, amygdala, and corona radiata) and in corpus callosum.

RESULTS Patients had decreased FA values compared with control subjects in 1) all areas (P = 0.025); 2) anterior (P < 0.001), mid- (P = 0.001), and posterior (P < 0.001) cingulate cortex; 3) prefrontal cortex gray matter (P < 0.001); 4) corona radiata (P < 0.001); 5) secondary sensory cortex (P = 0.008); and 6) anterior white matter (P = 0.045), anterior gray matter (P = 0.002), and posterior gray matter (P = 0.002) insula. No difference was found in corpus callosum (P > 0.05). The microstructural changes in some areas correlated with clinical parameters such as bloating (anterior insula), mental well-being (anterior insula, prefrontal cortex, and mid-cingulated and corona radiata), autonomic function based on electrocardiographic results (posterior insula and anterior cingulate), and presence of gastroparesis (anterior insula).

CONCLUSIONS The findings of this explorative study indicate that microstructural changes of brain areas involved in visceral sensory processing are associated with autonomic dysfunction and therefore may be involved in the pathogenesis of gastrointestinal symptoms in DM patients.
OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind36
Nummer3
Sider (fra-til)662-8
ISSN0149-5992
DOI
StatusUdgivet - mar. 2013

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