Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms. / Frøkjær, Jens Brøndum; Andersen, Lars Wiuff; Brock, Christina; Simrén, Magnus; Ljungberg, Maria; Søfteland, Eirik; Dimcevski, Georg; Yavarian, Yousef; Gregersen, Hans; Drewes, Asbjørn Mohr.

I: Diabetes Care, 2012.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Frøkjær, JB, Andersen, LW, Brock, C, Simrén, M, Ljungberg, M, Søfteland, E, Dimcevski, G, Yavarian, Y, Gregersen, H & Drewes, AM 2012, 'Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms', Diabetes Care. https://doi.org/10.2337/dc12-1131

APA

Frøkjær, J. B., Andersen, L. W., Brock, C., Simrén, M., Ljungberg, M., Søfteland, E., Dimcevski, G., Yavarian, Y., Gregersen, H., & Drewes, A. M. (2012). Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms. Diabetes Care. https://doi.org/10.2337/dc12-1131

CBE

Frøkjær JB, Andersen LW, Brock C, Simrén M, Ljungberg M, Søfteland E, Dimcevski G, Yavarian Y, Gregersen H, Drewes AM. 2012. Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms. Diabetes Care. https://doi.org/10.2337/dc12-1131

MLA

Vancouver

Author

Frøkjær, Jens Brøndum ; Andersen, Lars Wiuff ; Brock, Christina ; Simrén, Magnus ; Ljungberg, Maria ; Søfteland, Eirik ; Dimcevski, Georg ; Yavarian, Yousef ; Gregersen, Hans ; Drewes, Asbjørn Mohr. / Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms. I: Diabetes Care. 2012.

Bibtex

@article{230d30a9d63c4ecca9aa1f59028d9f2b,
title = "Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms",
abstract = "OBJECTIVEIn patients with long-standing diabetes mellitus (DM), there is increasing evidence for abnormal processing of gastrointestinal sensations in the central nervous system. Using magnetic resonance diffusion tensor imaging, we characterized brain microstructure in areas involved in visceral sensory processing and correlated these findings to clinical parameters.RESEARCH DESIGN AND METHODSTwenty-six patients with DM and gastrointestinal symptoms and 23 healthy control subjects were studied in a 3T scanner. The apparent diffusion coefficient (i.e., diffusivity of water) and fractional anisotropy (FA) (i.e., organization of fibers) were assessed in the {"}sensory matrix{"} (cingulate cortex, insula, prefrontal and secondary sensory cortex, amygdala, and corona radiata) and in corpus callosum.RESULTSPatients had decreased FA values compared with control subjects: 1) all areas (P = 0.025); 2) anterior (P <0.001), mid- (P = 0.001), and posterior (P <0.001) cingulate cortex; 3) prefrontal cortex gray matter (P <0.001); 4) corona radiata (P <0.001); 5) secondary sensory cortex (P = 0.008); 6) anterior white matter (P = 0.045); and anterior gray matter (P = 0.002) and posterior gray matter (P = 0.002) insula. No difference was found in corpus callosum (P > 0.05). The microstructural changes were for some areas correlated to clinical parameters such as bloating (anterior insula), mental well-being (anterior insula, prefrontal cortex, and mid-cingulated and corona radiata), autonomic function based on electrocardiographic results (posterior insula and anterior cingulate), and presence of gastroparesis (anterior insula).CONCLUSIONSThe findings of this explorative study indicate that microstructural changes of brain areas involved in visceral sensory processing are associated with autonomic dysfunction and therefore may be involved in the pathogenesis of gastrointestinal symptoms in DM patients.",
author = "Fr{\o}kj{\ae}r, {Jens Br{\o}ndum} and Andersen, {Lars Wiuff} and Christina Brock and Magnus Simr{\'e}n and Maria Ljungberg and Eirik S{\o}fteland and Georg Dimcevski and Yousef Yavarian and Hans Gregersen and Drewes, {Asbj{\o}rn Mohr}",
year = "2012",
doi = "10.2337/dc12-1131",
language = "English",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",

}

RIS

TY - JOUR

T1 - Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients With Diabetes Mellitus and Gastrointestinal Symptoms

AU - Frøkjær, Jens Brøndum

AU - Andersen, Lars Wiuff

AU - Brock, Christina

AU - Simrén, Magnus

AU - Ljungberg, Maria

AU - Søfteland, Eirik

AU - Dimcevski, Georg

AU - Yavarian, Yousef

AU - Gregersen, Hans

AU - Drewes, Asbjørn Mohr

PY - 2012

Y1 - 2012

N2 - OBJECTIVEIn patients with long-standing diabetes mellitus (DM), there is increasing evidence for abnormal processing of gastrointestinal sensations in the central nervous system. Using magnetic resonance diffusion tensor imaging, we characterized brain microstructure in areas involved in visceral sensory processing and correlated these findings to clinical parameters.RESEARCH DESIGN AND METHODSTwenty-six patients with DM and gastrointestinal symptoms and 23 healthy control subjects were studied in a 3T scanner. The apparent diffusion coefficient (i.e., diffusivity of water) and fractional anisotropy (FA) (i.e., organization of fibers) were assessed in the "sensory matrix" (cingulate cortex, insula, prefrontal and secondary sensory cortex, amygdala, and corona radiata) and in corpus callosum.RESULTSPatients had decreased FA values compared with control subjects: 1) all areas (P = 0.025); 2) anterior (P <0.001), mid- (P = 0.001), and posterior (P <0.001) cingulate cortex; 3) prefrontal cortex gray matter (P <0.001); 4) corona radiata (P <0.001); 5) secondary sensory cortex (P = 0.008); 6) anterior white matter (P = 0.045); and anterior gray matter (P = 0.002) and posterior gray matter (P = 0.002) insula. No difference was found in corpus callosum (P > 0.05). The microstructural changes were for some areas correlated to clinical parameters such as bloating (anterior insula), mental well-being (anterior insula, prefrontal cortex, and mid-cingulated and corona radiata), autonomic function based on electrocardiographic results (posterior insula and anterior cingulate), and presence of gastroparesis (anterior insula).CONCLUSIONSThe findings of this explorative study indicate that microstructural changes of brain areas involved in visceral sensory processing are associated with autonomic dysfunction and therefore may be involved in the pathogenesis of gastrointestinal symptoms in DM patients.

AB - OBJECTIVEIn patients with long-standing diabetes mellitus (DM), there is increasing evidence for abnormal processing of gastrointestinal sensations in the central nervous system. Using magnetic resonance diffusion tensor imaging, we characterized brain microstructure in areas involved in visceral sensory processing and correlated these findings to clinical parameters.RESEARCH DESIGN AND METHODSTwenty-six patients with DM and gastrointestinal symptoms and 23 healthy control subjects were studied in a 3T scanner. The apparent diffusion coefficient (i.e., diffusivity of water) and fractional anisotropy (FA) (i.e., organization of fibers) were assessed in the "sensory matrix" (cingulate cortex, insula, prefrontal and secondary sensory cortex, amygdala, and corona radiata) and in corpus callosum.RESULTSPatients had decreased FA values compared with control subjects: 1) all areas (P = 0.025); 2) anterior (P <0.001), mid- (P = 0.001), and posterior (P <0.001) cingulate cortex; 3) prefrontal cortex gray matter (P <0.001); 4) corona radiata (P <0.001); 5) secondary sensory cortex (P = 0.008); 6) anterior white matter (P = 0.045); and anterior gray matter (P = 0.002) and posterior gray matter (P = 0.002) insula. No difference was found in corpus callosum (P > 0.05). The microstructural changes were for some areas correlated to clinical parameters such as bloating (anterior insula), mental well-being (anterior insula, prefrontal cortex, and mid-cingulated and corona radiata), autonomic function based on electrocardiographic results (posterior insula and anterior cingulate), and presence of gastroparesis (anterior insula).CONCLUSIONSThe findings of this explorative study indicate that microstructural changes of brain areas involved in visceral sensory processing are associated with autonomic dysfunction and therefore may be involved in the pathogenesis of gastrointestinal symptoms in DM patients.

U2 - 10.2337/dc12-1131

DO - 10.2337/dc12-1131

M3 - Journal article

C2 - 23139372

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

ER -